Association between circadian rhythms and neurodegenerative diseases
Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circad...
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| Published in | Lancet neurology Vol. 18; no. 3; pp. 307 - 318 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.03.2019
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1474-4422 1474-4465 1474-4465 |
| DOI | 10.1016/S1474-4422(18)30461-7 |
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| Abstract | Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. The mechanistic link between circadian rhythms and neurodegeneration is still not fully understood, although proposed underlying pathways include alterations of protein homoeostasis and immune and inflammatory function. While preliminary clinical studies are promising, more studies of circadian rhythm disruptions and its mechanisms are required. Furthermore, clinical trials are needed to determine whether circadian interventions could prevent or delay the onset of neurodegenerative diseases. |
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| AbstractList | Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. The mechanistic link between circadian rhythms and neurodegeneration is still not fully understood, although proposed underlying pathways include alterations of protein homoeostasis and immune and inflammatory function. While preliminary clinical studies are promising, more studies of circadian rhythm disruptions and its mechanisms are required. Furthermore, clinical trials are needed to determine whether circadian interventions could prevent or delay the onset of neurodegenerative diseases. Summary Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. The mechanistic link between circadian rhythms and neurodegeneration is still not fully understood, although proposed underlying pathways include alterations of protein homoeostasis and immune and inflammatory function. While preliminary clinical studies are promising, more studies of circadian rhythm disruptions and its mechanisms are required. Furthermore, clinical trials are needed to determine whether circadian interventions could prevent or delay the onset of neurodegenerative diseases. Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. The mechanistic link between circadian rhythms and neurodegeneration is still not fully understood, although proposed underlying pathways include alterations of protein homoeostasis and immune and inflammatory function. While preliminary clinical studies are promising, more studies of circadian rhythm disruptions and its mechanisms are required. Furthermore, clinical trials are needed to determine whether circadian interventions could prevent or delay the onset of neurodegenerative diseases.Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. The mechanistic link between circadian rhythms and neurodegeneration is still not fully understood, although proposed underlying pathways include alterations of protein homoeostasis and immune and inflammatory function. While preliminary clinical studies are promising, more studies of circadian rhythm disruptions and its mechanisms are required. Furthermore, clinical trials are needed to determine whether circadian interventions could prevent or delay the onset of neurodegenerative diseases. Dysfunction in 24-h circadian rhythms is a common occurrence in aging adults, however, circadian rhythm disruptions (CRD) are more severe in people with age-related neurodegenerative diseases, including Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease (PD). Manifestations of CRD differ according to type and severity of neurodegenerative disease, and importantly, could occur before onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that—in addition to being a symptom of neurodegeneration—CRD might also be a potential risk factor for developing ADRD and PD, although large, longitudinal studies are needed to confirm this. The mechanistic link between circadian rhythms and neurodegeneration is not fully understood, although proposed underlying pathways include alterations in protein homeostasis, and immune and inflammatory function. While preliminary clinical studies are promising, more studies of CRD and its mechanisms are needed, and treatment trials are required to determine whether circadian interventions may prevent or delay the onset of neurodegenerative diseases. |
| Author | Hu, Kun Cappuccio, Francesco P Yaffe, Kristine Musiek, Erik S Leng, Yue |
| AuthorAffiliation | 2. Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, China 5. Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA 4. Medical Biodynamcis Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA 1. Department of Psychiatry, University of California, San Francisco, 4150 Clement Street, San Francisco VA Medical Center, CA 94121, USA 3. Department of Neurology, Hope Center for Neurological Disorders, and Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA 7. Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, San Francisco VA Medical Center, San Francisco, CA 94121, USA 6. Division of Health Sciences (Mental Health and Wellbeing), Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK |
| AuthorAffiliation_xml | – name: 5. Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA – name: 1. Department of Psychiatry, University of California, San Francisco, 4150 Clement Street, San Francisco VA Medical Center, CA 94121, USA – name: 6. Division of Health Sciences (Mental Health and Wellbeing), Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK – name: 7. Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, San Francisco VA Medical Center, San Francisco, CA 94121, USA – name: 3. Department of Neurology, Hope Center for Neurological Disorders, and Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA – name: 2. Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, China – name: 4. Medical Biodynamcis Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA |
| Author_xml | – sequence: 1 givenname: Yue surname: Leng fullname: Leng, Yue email: yue.leng@ucsf.edu organization: Department of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA – sequence: 2 givenname: Erik S surname: Musiek fullname: Musiek, Erik S organization: Hope Center for Neurological Disorders and Knight Alzheimer Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA – sequence: 3 givenname: Kun surname: Hu fullname: Hu, Kun organization: Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA – sequence: 4 givenname: Francesco P surname: Cappuccio fullname: Cappuccio, Francesco P organization: Division of Health Sciences (Mental Health and Wellbeing), Warwick Medical School, University of Warwick, Coventry, UK – sequence: 5 givenname: Kristine surname: Yaffe fullname: Yaffe, Kristine organization: Department of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30784558$$D View this record in MEDLINE/PubMed |
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| Snippet | Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related... Summary Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with... Dysfunction in 24-h circadian rhythms is a common occurrence in aging adults, however, circadian rhythm disruptions (CRD) are more severe in people with... |
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| SubjectTerms | Age Aged Aged, 80 and over Aging Alzheimer Disease - physiopathology Alzheimer's disease Biomarkers Blood pressure Body temperature Chronobiology Disorders - physiopathology Circadian rhythm Circadian Rhythm - physiology Circadian rhythms Clinical trials Cognition & reasoning Dementia Female Gene expression Hormones Humans Inflammation Longitudinal Studies Male Melatonin Middle Aged Movement disorders Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology Older people Parkinson Disease - physiopathology Parkinson's disease Sleep - physiology Sleep deprivation Sleep Wake Disorders - physiopathology |
| Title | Association between circadian rhythms and neurodegenerative diseases |
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