Association between circadian rhythms and neurodegenerative diseases

• Published in: Lancet neurology Vol. 18; no. 3; pp. 307 - 318
• Main Authors: Leng, Yue, Musiek, Erik S, Hu, Kun, Cappuccio, Francesco P, Yaffe, Kristine
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2019; Elsevier Limited
• Subjects: Age; Aged; Aged, 80 and over; Aging; Alzheimer Disease - physiopathology; Alzheimer's disease; Biomarkers; Blood pressure; Body temperature; Chronobiology Disorders - physiopathology; Circadian rhythm; Circadian Rhythm - physiology; Circadian rhythms; Clinical trials; Cognition & reasoning; Dementia; Female; Gene expression; Hormones; Humans; Inflammation; Longitudinal Studies; Male; Melatonin; Middle Aged; Movement disorders; Neurodegeneration; Neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - physiopathology; Older people; Parkinson Disease - physiopathology; Parkinson's disease; Sleep - physiology; Sleep deprivation; Sleep Wake Disorders - physiopathology
• ISSN: 1474-4422; 1474-4465; 1474-4465
• DOI: 10.1016/S1474-4422(18)30461-7

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. The mechanistic link between circadian rhythms and neurodegeneration is still not fully understood, although proposed underlying pathways include alterations of protein homoeostasis and immune and inflammatory function. While preliminary clinical studies are promising, more studies of circadian rhythm disruptions and its mechanisms are required. Furthermore, clinical trials are needed to determine whether circadian interventions could prevent or delay the onset of neurodegenerative diseases.