Absorption and Tissue Distribution of Siphonaxanthin from Green Algae

Siphonaxanthin has been known to possess inhibitory effects against obesity, inflammation, and angiogenesis. However, little information on its in vivo bioavailability and biotransformation is available. To assess the bioavailability and metabolism of siphonaxanthin, its absorption and accumulation...

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Published inMarine drugs Vol. 18; no. 6; p. 291
Main Authors Li, Zhuosi, Zheng, Jiawen, Luo, Xiaolin, Manabe, Yuki, Hirata, Takashi, Sugawara, Tatsuya
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.06.2020
MDPI
Subjects
Absorption
Accumulation
Adipose Tissue
Adipose Tissue, White
Algae
Angiogenesis
Animals
Aquatic plants
bioactive properties
Bioavailability
Biological activity
Biological Availability
Biotransformation
Caco-2 Cells
Carotenoids
dehydro-metabolite
Diet
Distribution
Food
Humans
inflammation
Intestine
Intestines
Lipid Metabolism
Lipids
liver
Liver - metabolism
Mass spectra
metabolic pathway in vivo
Metabolism
Metabolites
Mice
Obesity
siphonaxanthin
Small intestine
Stomach
Tissue Distribution
white adipose tissue
Xanthophylls - chemistry
Xanthophylls - metabolism
Xanthophylls - pharmacokinetics
siphonaxanthin
metabolic pathway in vivo
white adipose tissue
dehydro-metabolite
Online AccessGet full text
ISSN1660-3397
1660-3397
DOI10.3390/md18060291

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Abstract Siphonaxanthin has been known to possess inhibitory effects against obesity, inflammation, and angiogenesis. However, little information on its in vivo bioavailability and biotransformation is available. To assess the bioavailability and metabolism of siphonaxanthin, its absorption and accumulation were evaluated using intestinal Caco-2 cells and Institute of Cancer Research (ICR) mice. Siphonaxanthin was absorbed and exhibited non-uniform accumulation and distribution patterns in tissues of ICR mice. Notably, in addition to siphonaxanthin, three main compounds were detected following dietary administration of siphonaxanthin. Because the compounds showed changes on mass spectra compared with that of siphonaxanthin, they were presumed to be metabolites of siphonaxanthin in ICR mice. Siphonaxanthin mainly accumulated in stomach and small intestine, while putative metabolites of siphonaxanthin mainly accumulated in liver and adipose tissues. Furthermore, siphonaxanthin and its putative metabolites selectively accumulated in white adipose tissue (WAT), especially mesenteric WAT. These results provide useful evidence regarding the in vivo bioactivity of siphonaxanthin. In particular, the results regarding the specific accumulation of siphonaxanthin and its metabolites in WAT have important implications for understanding their anti-obesity effects and regulatory roles in lipid metabolism.
AbstractList Siphonaxanthin has been known to possess inhibitory effects against obesity, inflammation, and angiogenesis. However, little information on its in vivo bioavailability and biotransformation is available. To assess the bioavailability and metabolism of siphonaxanthin, its absorption and accumulation were evaluated using intestinal Caco-2 cells and Institute of Cancer Research (ICR) mice. Siphonaxanthin was absorbed and exhibited non-uniform accumulation and distribution patterns in tissues of ICR mice. Notably, in addition to siphonaxanthin, three main compounds were detected following dietary administration of siphonaxanthin. Because the compounds showed changes on mass spectra compared with that of siphonaxanthin, they were presumed to be metabolites of siphonaxanthin in ICR mice. Siphonaxanthin mainly accumulated in stomach and small intestine, while putative metabolites of siphonaxanthin mainly accumulated in liver and adipose tissues. Furthermore, siphonaxanthin and its putative metabolites selectively accumulated in white adipose tissue (WAT), especially mesenteric WAT. These results provide useful evidence regarding the in vivo bioactivity of siphonaxanthin. In particular, the results regarding the specific accumulation of siphonaxanthin and its metabolites in WAT have important implications for understanding their anti-obesity effects and regulatory roles in lipid metabolism.
Siphonaxanthin has been known to possess inhibitory effects against obesity, inflammation, and angiogenesis. However, little information on its in vivo bioavailability and biotransformation is available. To assess the bioavailability and metabolism of siphonaxanthin, its absorption and accumulation were evaluated using intestinal Caco-2 cells and Institute of Cancer Research (ICR) mice. Siphonaxanthin was absorbed and exhibited non-uniform accumulation and distribution patterns in tissues of ICR mice. Notably, in addition to siphonaxanthin, three main compounds were detected following dietary administration of siphonaxanthin. Because the compounds showed changes on mass spectra compared with that of siphonaxanthin, they were presumed to be metabolites of siphonaxanthin in ICR mice. Siphonaxanthin mainly accumulated in stomach and small intestine, while putative metabolites of siphonaxanthin mainly accumulated in liver and adipose tissues. Furthermore, siphonaxanthin and its putative metabolites selectively accumulated in white adipose tissue (WAT), especially mesenteric WAT. These results provide useful evidence regarding the in vivo bioactivity of siphonaxanthin. In particular, the results regarding the specific accumulation of siphonaxanthin and its metabolites in WAT have important implications for understanding their anti-obesity effects and regulatory roles in lipid metabolism.Siphonaxanthin has been known to possess inhibitory effects against obesity, inflammation, and angiogenesis. However, little information on its in vivo bioavailability and biotransformation is available. To assess the bioavailability and metabolism of siphonaxanthin, its absorption and accumulation were evaluated using intestinal Caco-2 cells and Institute of Cancer Research (ICR) mice. Siphonaxanthin was absorbed and exhibited non-uniform accumulation and distribution patterns in tissues of ICR mice. Notably, in addition to siphonaxanthin, three main compounds were detected following dietary administration of siphonaxanthin. Because the compounds showed changes on mass spectra compared with that of siphonaxanthin, they were presumed to be metabolites of siphonaxanthin in ICR mice. Siphonaxanthin mainly accumulated in stomach and small intestine, while putative metabolites of siphonaxanthin mainly accumulated in liver and adipose tissues. Furthermore, siphonaxanthin and its putative metabolites selectively accumulated in white adipose tissue (WAT), especially mesenteric WAT. These results provide useful evidence regarding the in vivo bioactivity of siphonaxanthin. In particular, the results regarding the specific accumulation of siphonaxanthin and its metabolites in WAT have important implications for understanding their anti-obesity effects and regulatory roles in lipid metabolism.
Author Li, Zhuosi
Sugawara, Tatsuya
Zheng, Jiawen
Manabe, Yuki
Hirata, Takashi
Luo, Xiaolin
AuthorAffiliation 1 Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 6068502, Japan; lizhuosi624@gmail.com (Z.L.); feitianmao0715@gmail.com (J.Z.); shelyluo@gmail.com (X.L.); manabe.yuki.8c@kyoto-u.ac.jp (Y.M.); hiratan@mbox.kyoto-inet.or.jp (T.H.)
2 Department of Rehabilitation, Shijonawate Gakuen University, Osaka 5740011, Japan
AuthorAffiliation_xml – name: 1 Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 6068502, Japan; lizhuosi624@gmail.com (Z.L.); feitianmao0715@gmail.com (J.Z.); shelyluo@gmail.com (X.L.); manabe.yuki.8c@kyoto-u.ac.jp (Y.M.); hiratan@mbox.kyoto-inet.or.jp (T.H.)
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Keywords siphonaxanthin
metabolic pathway in vivo
white adipose tissue
dehydro-metabolite
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Snippet Siphonaxanthin has been known to possess inhibitory effects against obesity, inflammation, and angiogenesis. However, little information on its in vivo...
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StartPage 291
SubjectTerms Absorption
Accumulation
Adipose Tissue
Adipose Tissue, White
Algae
Angiogenesis
Animals
Aquatic plants
bioactive properties
Bioavailability
Biological activity
Biological Availability
Biotransformation
Caco-2 Cells
Carotenoids
dehydro-metabolite
Diet
Distribution
Food
Humans
inflammation
Intestine
Intestines
Lipid Metabolism
Lipids
liver
Liver - metabolism
Mass spectra
metabolic pathway in vivo
Metabolism
Metabolites
Mice
Obesity
siphonaxanthin
Small intestine
Stomach
Tissue Distribution
white adipose tissue
Xanthophylls - chemistry
Xanthophylls - metabolism
Xanthophylls - pharmacokinetics
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Title Absorption and Tissue Distribution of Siphonaxanthin from Green Algae
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