Diversity in EWAS: current state, challenges, and solutions

Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generatio...

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Bibliographic Details
Published inGenome medicine Vol. 14; no. 1; pp. 1 - 4
Main Authors Breeze, Charles E., Wong, Jason Y. Y., Beck, Stephan, Berndt, Sonja I., Franceschini, Nora
Format Journal Article
LanguageEnglish
Published London BioMed Central 06.07.2022
BioMed Central Ltd
BMC
Subjects
African Americans
Bioinformatics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Comment
DNA methylation
Epigenetic inheritance
Epigenetics
Genetic polymorphisms
Genomics
Human Genetics
Medicine/Public Health
Metabolomics
Methylation
Multiculturalism & pluralism
Systems Biology
Variable region
Online AccessGet full text
ISSN1756-994X
1756-994X
DOI10.1186/s13073-022-01065-3

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Summary:Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis.
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ISSN:1756-994X
1756-994X
DOI:10.1186/s13073-022-01065-3