肾小管酸中毒伴骨软化继发于干燥综合征1例并文献分析

目的分析干燥综合征（Sjgren’s syndrome,SS）并发肾小管酸中毒伴骨软化症少见首发症状的特点。方法采用病例回顾方法讨论干燥综合征累及肾小管酸中毒伴骨软化的特点并结合文献复习。结果 Pubmed检索的10例患者均为女性,平均年龄47岁,首发症状均不同,多以（60%）骨痛和肢体无力起病,治疗上纠正酸中毒,中性磷对症治疗,系统性应用糖皮质激素被证明有效。结论肾小管酸中毒引起的骨软化症起病的患者极易误诊,这种少见表现应作为SS鉴别诊断之一。...

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Published in中国骨质疏松杂志 Vol. 21; no. 12; pp. 1487 - 1490
Main Author 武加标 施冶青 赵东宝
Format Journal Article
LanguageChinese
Published 江苏大学附属武进医院风湿科,江苏常州,213017%第二军医大学长海医院风湿免疫科,上海,200433 2015
Subjects
干燥综合征
肾小管酸中毒
骨软化症
Sj(o)gren's syndrome
肾小管酸中毒
骨软化症
Osteomalacia
Renal tubular acidosis
干燥综合征
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ISSN1006-7108
DOI10.3969/j.issn.1006-7108.2015.12.015

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Summary:目的分析干燥综合征（Sjgren’s syndrome,SS）并发肾小管酸中毒伴骨软化症少见首发症状的特点。方法采用病例回顾方法讨论干燥综合征累及肾小管酸中毒伴骨软化的特点并结合文献复习。结果 Pubmed检索的10例患者均为女性,平均年龄47岁,首发症状均不同,多以（60%）骨痛和肢体无力起病,治疗上纠正酸中毒,中性磷对症治疗,系统性应用糖皮质激素被证明有效。结论肾小管酸中毒引起的骨软化症起病的患者极易误诊,这种少见表现应作为SS鉴别诊断之一。
Bibliography:WU Jiabiao,SHI Yeqing,ZHAO Dongbao 1. Department of Rheumatology, Wujin Hospital, Jiangsu University, Changzhou 213017, Jiangsu 2. Department of Rheumatology, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
Sjgren＇s syndrome; Renal tubular acidosis; Osteomalacia
11-3701/R
Objective To analyzethecharacteristics of thehypophosphatemic osteomalacia associated with renal tubular acidosis（ RTA） in elderly women with primary Sjgren＇s syndrome（ SS）. Methods Retrospectivemethod was used to report a caseof RTA with SS. Theassociated literatures werereviewed. Results Ten cases of SS and RTA associated with osteomalacia had been reported in women,with a mean ageof 47 years old. Bonepain and weakness of theextremities werethefirst symptom in 60% of thecases. Anti-acidosis treatment,phosphorus treatment,and systemic useof corticosteroids werereported to beeffective.Conclusion Patients with osteomalacia dueto RTA areeasily misdiagnosed. It should bedifferentially diagnosed with SS.
ISSN:1006-7108
DOI:10.3969/j.issn.1006-7108.2015.12.015