Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome
Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied. To assess the roles of nonsaponin fractions (NS) in NLRP3...
Saved in:
Published in | Journal of ginseng research Vol. 41; no. 4; pp. 513 - 523 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
Elsevier B.V
01.10.2017
고려인삼학회 Elsevier |
Subjects | |
Online Access | Get full text |
ISSN | 1226-8453 2093-4947 2093-4947 |
DOI | 10.1016/j.jgr.2016.10.001 |
Cover
Abstract | Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied.
To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated transcription of pro-interleukin (IL)-1β and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1β maturation. In addition, we examined the role of NS in IL-6 production and IL-1β maturation in mice.
NS induced IL-1β and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1β maturation and IL-6 production.
SF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator. |
---|---|
AbstractList | Background: Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied. Methods: To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated transcription of pro-interleukin (IL)-1β and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1β maturation. In addition, we examined the role of NS in IL-6 production and IL-1β maturation in mice. Results: NS induced IL-1β and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1β maturation and IL-6 production. Conclusion: SF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator. Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied.BACKGROUNDKorean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied.To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated transcription of pro-interleukin (IL)-1β and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1β maturation. In addition, we examined the role of NS in IL-6 production and IL-1β maturation in mice.METHODSTo assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated transcription of pro-interleukin (IL)-1β and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1β maturation. In addition, we examined the role of NS in IL-6 production and IL-1β maturation in mice.NS induced IL-1β and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1β maturation and IL-6 production.RESULTSNS induced IL-1β and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1β maturation and IL-6 production.SF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator.CONCLUSIONSF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator. Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied. To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated transcription of pro-interleukin (IL)-1β and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1β maturation. In addition, we examined the role of NS in IL-6 production and IL-1β maturation in mice. NS induced IL-1β and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1β maturation and IL-6 production. SF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator. Background: Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied. Methods: To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)-mediated transcription of pro-interleukin (IL)-1b and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1b maturation. In addition, we examined the role of NS in IL-6 production and IL-1b maturation in mice. Results: NS induced IL-1b and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1b maturation and IL-6 production. Conclusion: SF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator. KCI Citation Count: 25 Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied.To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated transcription of pro-interleukin (IL)-1β and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1β maturation. In addition, we examined the role of NS in IL-6 production and IL-1β maturation in mice.NS induced IL-1β and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1β maturation and IL-6 production.SF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator. |
Author | Lee, Geun-Shik Lee, Seung-Ho Kim, Cheon Ho Jeon, Eunsaem Seo, Sanghoon Jang, Kyoung Hwa Ahn, Huijeong Lee, Jiseon Han, Byung-Cheol |
AuthorAffiliation | 2 Korea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon, Republic of Korea 1 College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea |
AuthorAffiliation_xml | – name: 1 College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea – name: 2 Korea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon, Republic of Korea |
Author_xml | – sequence: 1 givenname: Byung-Cheol surname: Han fullname: Han, Byung-Cheol organization: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea – sequence: 2 givenname: Huijeong surname: Ahn fullname: Ahn, Huijeong organization: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea – sequence: 3 givenname: Jiseon surname: Lee fullname: Lee, Jiseon organization: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea – sequence: 4 givenname: Eunsaem surname: Jeon fullname: Jeon, Eunsaem organization: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea – sequence: 5 givenname: Sanghoon surname: Seo fullname: Seo, Sanghoon organization: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea – sequence: 6 givenname: Kyoung Hwa surname: Jang fullname: Jang, Kyoung Hwa organization: Korea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon, Republic of Korea – sequence: 7 givenname: Seung-Ho surname: Lee fullname: Lee, Seung-Ho organization: Korea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon, Republic of Korea – sequence: 8 givenname: Cheon Ho surname: Kim fullname: Kim, Cheon Ho organization: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea – sequence: 9 givenname: Geun-Shik orcidid: 0000-0002-3149-8433 surname: Lee fullname: Lee, Geun-Shik email: leegeun@kangwon.ac.kr organization: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29021698$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002274267$$DAccess content in National Research Foundation of Korea (NRF) |
BookMark | eNqNUl1v0zAUjdAQ6wo_gBeUFyR4aPFXnFhISNMYo6LqUDVeeLEc56a4S-xip4X9e5ymVIyHQV4c2-ccn3vPPUtOrLOQJM8xmmKE-Zv1dL3yUxJ_436KEH6UjAgSdMIEy0-SESaETwqW0dPkLIQ1QjwnOXuSnBKBCOaiGCVfF84GtXHW2LT2Sncm7lNXp5-cB2XTJVTplbEB7CqFn12PCOnGmxbSHrxTPaHHL-bLzzQ1tm5U26rgWniaPK5VE-DZYR0nXz5c3lx8nMyvr2YX5_OJ5ph1E6xEpQgrecaYFlBzRkiWs0xURTSMM4pJmYsaAwZEoGIl1YiyEoECpTNU03HyetC1vpa32kinzH5dOXnr5fnyZiYJ4gLjImJnA7Zyai37OpS_2xP2B86vpPKd0Q1IlsXG5lD2fWKlKhTOkMh4lVOtiroooxYZtLZ2o-5-qKY5CmIk-4DkWsaAZB9QfxQDiqR3A2mzLVuoNNjY0-aek_s31nyLhexkxklB4zdOXh0EvPu-hdDJ1gQNTaMsuG2QhFPOKGUZ_icUiwwxnDPRq77409bRz-9BiQA8ALR3IXio_6vW_C-ONt1-YGJlpnmQ-fIQ6bYftcqo43OL6_eXKI-9EKy3_XbAQZyvnQEvgzZgdWR40F0M1Tzwyi_vGALF |
CitedBy_id | crossref_primary_10_1007_s11259_020_09772_1 crossref_primary_10_1016_j_foodres_2020_109306 crossref_primary_10_1016_j_jgr_2020_06_002 crossref_primary_10_1016_j_cyto_2019_154983 crossref_primary_10_3390_molecules29071455 crossref_primary_10_1016_j_phymed_2019_153019 crossref_primary_10_1016_j_biopha_2018_09_169 crossref_primary_10_1016_j_jep_2019_01_044 crossref_primary_10_1016_j_jgr_2022_09_004 crossref_primary_10_1007_s11259_018_9729_x crossref_primary_10_1002_ptr_7118 crossref_primary_10_1038_s41598_018_31717_7 crossref_primary_10_1080_09540105_2020_1854189 crossref_primary_10_1016_j_jgr_2021_12_009 crossref_primary_10_4049_jimmunol_2300745 crossref_primary_10_1016_j_jgr_2017_08_003 crossref_primary_10_1016_j_intimp_2020_106805 crossref_primary_10_1038_s41598_017_12635_6 crossref_primary_10_1016_j_jgr_2021_02_002 crossref_primary_10_1016_j_jgr_2023_02_006 crossref_primary_10_1016_j_jgr_2022_02_003 crossref_primary_10_1016_j_jgr_2020_02_004 crossref_primary_10_1007_s10787_023_01380_0 crossref_primary_10_1038_s41598_022_27129_3 crossref_primary_10_1016_j_jgr_2018_03_003 crossref_primary_10_1016_j_jep_2021_114927 |
Cites_doi | 10.1089/107999004322813336 10.5142/jgr.2012.36.2.119 10.1056/NEJMoa065213 10.1007/s11259-014-9602-5 10.1016/j.imlet.2013.12.017 10.1007/BF02705630 10.4049/jimmunol.0901363 10.1155/2012/732860 10.5142/jgr.2012.36.4.354 10.5142/jgr.2011.35.4.479 10.4049/jimmunol.1100613 10.1016/j.cell.2010.01.040 10.1016/j.intimp.2006.04.021 10.1186/ar2143 10.1038/nrendo.2009.62 10.1038/nri3452 10.5582/ddt.2015.01004 10.1271/bbb.80085 10.1081/IPH-120014730 10.1016/j.tem.2010.08.007 10.1038/nm.2279 10.1146/annurev-physiol-021113-170324 10.2174/157016109788340767 10.1016/j.canlet.2003.09.037 10.1055/s-2001-12005 10.1038/nri2936 10.1016/0306-3623(93)90435-Z 10.1038/ni.2022 10.1016/j.ejphar.2008.01.026 |
ContentType | Journal Article |
Copyright | 2016 2016 The Korean Society of Ginseng, Published by Elsevier Korea LLC. 2016 |
Copyright_xml | – notice: 2016 – notice: 2016 The Korean Society of Ginseng, Published by Elsevier Korea LLC. 2016 |
DBID | 6I. AAFTH DBRKI TDB AAYXX CITATION NPM 7X8 7S9 L.6 5PM ADTOC UNPAY DOA ACYCR |
DOI | 10.1016/j.jgr.2016.10.001 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access DBPIA - 디비피아 Nurimedia DBPIA Journals CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ - Directory of Open Access Journals Korean Citation Index |
DatabaseTitle | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
DatabaseTitleList | MEDLINE - Academic AGRICOLA PubMed |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Agriculture |
EISSN | 2093-4947 |
EndPage | 523 |
ExternalDocumentID | oai_kci_go_kr_ARTI_2069118 oai_doaj_org_article_452017eb16984ba8a150956d73ca8f8b 10.1016/j.jgr.2016.10.001 PMC5628333 29021698 10_1016_j_jgr_2016_10_001 NODE07283943 S1226845316302317 |
Genre | Journal Article |
GroupedDBID | .UV 0SF 4.4 457 5VS 6I. 9ZL AACTN AAEDT AAEDW AAFTH AAIKJ AALRI AAXUO AAYYP ABMAC ACGFS ADEZE ADRAZ AENEX AEXQZ AFTJW AGHFR AITUG AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ DBRKI DIK EBS EJD F5P FDB GROUPED_DOAJ GX1 HYE IPNFZ IXB JDI KQ8 KVFHK M48 M~E NCXOZ RIG ROL RPM SSZ TDB 0R~ AAHBH ADVLN GW5 PGMZT AAYWO AAYXX ACVFH ADCNI AEUPX AFPUW AIGII AKBMS AKYEP CITATION NPM 7X8 7S9 L.6 5PM ADTOC UNPAY ACYCR |
ID | FETCH-LOGICAL-c614t-1a9da24b6544c9ef642257459d800615312b79f1e1e02ed4b3c034b0eaeac50f3 |
IEDL.DBID | M48 |
ISSN | 1226-8453 2093-4947 |
IngestDate | Tue Jun 25 21:08:36 EDT 2024 Mon Sep 08 19:51:31 EDT 2025 Tue Aug 19 09:07:18 EDT 2025 Thu Aug 21 14:23:03 EDT 2025 Fri Jul 11 08:49:40 EDT 2025 Thu Jul 10 18:39:40 EDT 2025 Mon Jul 21 06:01:33 EDT 2025 Tue Jul 01 04:36:24 EDT 2025 Thu Apr 24 22:57:53 EDT 2025 Thu Mar 13 19:35:07 EDT 2025 Thu May 30 20:25:13 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | cytokine NLRP3 interleukin-1beta Korean Red Ginseng extracts inflammasome |
Language | English |
License | This is an open access article under the CC BY-NC-ND license. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). cc-by-nc-nd |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c614t-1a9da24b6544c9ef642257459d800615312b79f1e1e02ed4b3c034b0eaeac50f3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
ORCID | 0000-0002-3149-8433 |
OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1016/j.jgr.2016.10.001 |
PMID | 29021698 |
PQID | 1950417493 |
PQPubID | 23479 |
PageCount | 11 |
ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_2069118 doaj_primary_oai_doaj_org_article_452017eb16984ba8a150956d73ca8f8b unpaywall_primary_10_1016_j_jgr_2016_10_001 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5628333 proquest_miscellaneous_2636433451 proquest_miscellaneous_1950417493 pubmed_primary_29021698 crossref_primary_10_1016_j_jgr_2016_10_001 crossref_citationtrail_10_1016_j_jgr_2016_10_001 nurimedia_primary_NODE07283943 elsevier_sciencedirect_doi_10_1016_j_jgr_2016_10_001 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 2000 |
PublicationDate | 2017-10-01 |
PublicationDateYYYYMMDD | 2017-10-01 |
PublicationDate_xml | – month: 10 year: 2017 text: 2017-10-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | Korea (South) |
PublicationPlace_xml | – name: Korea (South) |
PublicationTitle | Journal of ginseng research |
PublicationTitleAlternate | J Ginseng Res |
PublicationYear | 2017 |
Publisher | Elsevier B.V 고려인삼학회 Elsevier |
Publisher_xml | – name: Elsevier B.V – name: 고려인삼학회 – name: Elsevier |
References | Oh, Pae, Choi, Seo, Kim, Shin, Kim, Kim, Chung (bib22) 2004; 205 Lim, Bae, Jung, Kim, Yun, Song (bib24) 2002; 45 Choi, Kim, Sohn, Park, Kim, Moon, Rhee, Pyo (bib26) 2008; 72 Sohn, Jang, Lee, Jang, Kang, Park, Pyo (bib4) 2011; 35 Byeon, Lee, Kim, Yang, Kwak, Kim, Choung, Rhee, Cho (bib27) 2012; 2012 Park, Cho (bib18) 2009; 8 Wen, Gris, Lei, Jha, Zhang, Huang, Brickey, Ting (bib30) 2011; 12 Bauernfeind, Bartok, Rieger, Franchi, Nunez, Hornung (bib16) 2011; 187 Choo, Sakurai, Kim, Saiki (bib21) 2008; 19 Larina, Cho, Ten, Park (bib13) 2001; 18 Cho, Yoo, Baik, Park, Han (bib19) 2001; 67 Ru, Wang, Xu, He, Sun, Qian, Zhou, Qin (bib2) 2015; 9 Latz, Xiao, Stutz (bib11) 2013; 13 Feve, Bastard (bib31) 2009; 5 Lu, Yao, Chen (bib5) 2009; 7 Larsen, Faulenbach, Vaag, Volund, Ehses, Seifert, Mandrup-Poulsen, Donath (bib34) 2007; 356 Schroder, Tschopp (bib7) 2010; 140 Henao-Mejia, Elinav, Thaiss, Flavell (bib32) 2014; 76 Lamkanfi (bib8) 2011; 11 Kim, Ahn, Woo, Lee, Lee (bib12) 2014; 38 Baek, Bae, Park (bib3) 2012; 36 Wu, Bi, Yang, Zhan, Dong, Wang, Wang, Zhang, Li (bib20) 2007; 7 Ozaki, Campbell, Doyle (bib9) 2015; 8 Kawamoto, Ii, Kitazaki, Iizawa, Kimura (bib15) 2008; 584 So, De Smedt, Revaz, Tschopp (bib17) 2007; 9 Nakaya, Kita, Kuriyama, Iwakura, Imanishi (bib28) 2004; 24 Kim, Ahn, Han, Lee, Cho, Kim, Hong, An, Jeung, Lee (bib6) 2014; 158 Vandanmagsar, Youm, Ravussin, Galgani, Stadler, Mynatt, Ravussin, Stephens, Dixit (bib29) 2011; 17 Bauernfeind, Horvath, Stutz, Alnemri, MacDonald, Speert, Fernandes-Alnemri, Wu, Monks, Fitzgerald (bib10) 2009; 183 Ahn, Kang, Yoon, Kim, Kim, Lee (bib14) 2016 Shin, Song, Yun, Yang, Rhee, Pyo (bib25) 2002; 24 Stancheva, Alova (bib23) 1993; 24 Konner, Bruning (bib33) 2011; 22 Kang, Min (bib1) 2012; 36 Vandanmagsar (10.1016/j.jgr.2016.10.001_bib29) 2011; 17 Lamkanfi (10.1016/j.jgr.2016.10.001_bib8) 2011; 11 Larina (10.1016/j.jgr.2016.10.001_bib13) 2001; 18 Byeon (10.1016/j.jgr.2016.10.001_bib27) 2012; 2012 Choi (10.1016/j.jgr.2016.10.001_bib26) 2008; 72 Kim (10.1016/j.jgr.2016.10.001_bib6) 2014; 158 Oh (10.1016/j.jgr.2016.10.001_bib22) 2004; 205 Cho (10.1016/j.jgr.2016.10.001_bib19) 2001; 67 Kim (10.1016/j.jgr.2016.10.001_bib12) 2014; 38 Park (10.1016/j.jgr.2016.10.001_bib18) 2009; 8 Bauernfeind (10.1016/j.jgr.2016.10.001_bib10) 2009; 183 Stancheva (10.1016/j.jgr.2016.10.001_bib23) 1993; 24 Nakaya (10.1016/j.jgr.2016.10.001_bib28) 2004; 24 So (10.1016/j.jgr.2016.10.001_bib17) 2007; 9 Ahn (10.1016/j.jgr.2016.10.001_bib14) 2016 Feve (10.1016/j.jgr.2016.10.001_bib31) 2009; 5 Wu (10.1016/j.jgr.2016.10.001_bib20) 2007; 7 Shin (10.1016/j.jgr.2016.10.001_bib25) 2002; 24 Kang (10.1016/j.jgr.2016.10.001_bib1) 2012; 36 Schroder (10.1016/j.jgr.2016.10.001_bib7) 2010; 140 Ru (10.1016/j.jgr.2016.10.001_bib2) 2015; 9 Wen (10.1016/j.jgr.2016.10.001_bib30) 2011; 12 Lim (10.1016/j.jgr.2016.10.001_bib24) 2002; 45 Larsen (10.1016/j.jgr.2016.10.001_bib34) 2007; 356 Lu (10.1016/j.jgr.2016.10.001_bib5) 2009; 7 Choo (10.1016/j.jgr.2016.10.001_bib21) 2008; 19 Baek (10.1016/j.jgr.2016.10.001_bib3) 2012; 36 Henao-Mejia (10.1016/j.jgr.2016.10.001_bib32) 2014; 76 Bauernfeind (10.1016/j.jgr.2016.10.001_bib16) 2011; 187 Ozaki (10.1016/j.jgr.2016.10.001_bib9) 2015; 8 Sohn (10.1016/j.jgr.2016.10.001_bib4) 2011; 35 Latz (10.1016/j.jgr.2016.10.001_bib11) 2013; 13 Konner (10.1016/j.jgr.2016.10.001_bib33) 2011; 22 Kawamoto (10.1016/j.jgr.2016.10.001_bib15) 2008; 584 20303873 - Cell. 2010 Mar 19;140(6):821-32 19570822 - J Immunol. 2009 Jul 15;183(2):787-91 24691785 - Vet Res Commun. 2014 Sep;38(3):193-200 18299127 - Eur J Pharmacol. 2008 Apr 14;584(1):40-8 24418475 - Immunol Lett. 2014 Mar-Apr;158(1-2):143-50 17276889 - Int Immunopharmacol. 2007 Mar;7(3):313-20 23702978 - Nat Rev Immunol. 2013 Jun;13(6):397-411 17429083 - N Engl J Med. 2007 Apr 12;356(15):1517-26 21350580 - Nat Rev Immunol. 2011 Mar;11(3):213-20 20888253 - Trends Endocrinol Metab. 2011 Jan;22(1):16-23 11345690 - Planta Med. 2001 Apr;67(3):213-8 24274736 - Annu Rev Physiol. 2014;76:57-78 21217695 - Nat Med. 2011 Feb;17 (2):179-88 12375741 - Immunopharmacol Immunotoxicol. 2002 Aug;24(3):469-82 27133472 - Cell Mol Immunol. 2016 May 02;:null 14980073 - J Interferon Cytokine Res. 2004 Feb;24(2):93-100 23717112 - J Ginseng Res. 2012 Apr;36(2):119-34 23717137 - J Ginseng Res. 2012 Oct;36(4):354-68 22474399 - Mediators Inflamm. 2012;2012:732860 25653548 - J Inflamm Res. 2015 Jan 16;8:15-27 21677136 - J Immunol. 2011 Jul 15;187(2):613-7 21478880 - Nat Immunol. 2011 May;12 (5):408-15 19601854 - Curr Vasc Pharmacol. 2009 Jul;7(3):293-302 18603775 - Biosci Biotechnol Biochem. 2008 Jul;72(7):1817-25 17352828 - Arthritis Res Ther. 2007;9(2):R28 23717095 - J Ginseng Res. 2011 Nov;35(4):479-86 18288389 - Oncol Rep. 2008 Mar;19(3):595-600 8112520 - Gen Pharmacol. 1993 Nov;24(6):1459-62 12217729 - J Infect. 2002 Jul;45(1):32-8 19399017 - Nat Rev Endocrinol. 2009 Jun;5(6):305-11 25788049 - Drug Discov Ther. 2015 Feb;9(1):23-32 15036657 - Cancer Lett. 2004 Mar 8;205(1):23-9 |
References_xml | – volume: 9 start-page: 23 year: 2015 end-page: 32 ident: bib2 article-title: Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.) publication-title: Drug Discov Ther – volume: 8 start-page: 3682 year: 2009 end-page: 3690 ident: bib18 article-title: Anti-inflammatory effects of ginsenosides from publication-title: Afr J Biotechnol – volume: 7 start-page: 293 year: 2009 end-page: 302 ident: bib5 article-title: Ginseng compounds: an update on their molecular mechanisms and medical applications publication-title: Curr Vasc Pharmacol – volume: 45 start-page: 32 year: 2002 end-page: 38 ident: bib24 article-title: Anti-septicaemic effect of polysaccharide from publication-title: J Infect – year: 2016 ident: bib14 article-title: Poly-gamma-glutamic acid from publication-title: Cell Mol Immunol Forthcoming – volume: 12 start-page: 408 year: 2011 end-page: 415 ident: bib30 article-title: Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling publication-title: Nat Immunol – volume: 183 start-page: 787 year: 2009 end-page: 791 ident: bib10 article-title: Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression publication-title: J Immunol – volume: 205 start-page: 23 year: 2004 end-page: 29 ident: bib22 article-title: 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide publication-title: Cancer Lett – volume: 72 start-page: 1817 year: 2008 end-page: 1825 ident: bib26 article-title: Red ginseng acidic polysaccharide (RGAP) in combination with IFN-gamma results in enhanced macrophage function through activation of the NF-kappaB pathway publication-title: Biosci Biotechnol Biochem – volume: 584 start-page: 40 year: 2008 end-page: 48 ident: bib15 article-title: TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain publication-title: Eur J Pharmacol – volume: 8 start-page: 15 year: 2015 end-page: 27 ident: bib9 article-title: Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives publication-title: J Inflamm Res – volume: 17 start-page: 179 year: 2011 end-page: 188 ident: bib29 article-title: The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance publication-title: Nat Med – volume: 36 start-page: 354 year: 2012 end-page: 368 ident: bib1 article-title: Ginseng, the ‘immunity boost’: the effects of publication-title: J Ginseng Res – volume: 9 start-page: R28 year: 2007 ident: bib17 article-title: A pilot study of IL-1 inhibition by anakinra in acute gout publication-title: Arthritis Res Ther – volume: 38 start-page: 193 year: 2014 end-page: 200 ident: bib12 article-title: Characterization of porcine NLRP3 inflammasome activation and its upstream mechanism publication-title: Vet Res Commun – volume: 24 start-page: 1459 year: 1993 end-page: 1462 ident: bib23 article-title: Ginsenoside Rg1 inhibits the brain cAMP phosphodiesterase activity in young and aged rats publication-title: Gen Pharmacol – volume: 24 start-page: 469 year: 2002 end-page: 482 ident: bib25 article-title: Immunostimulating effects of acidic polysaccharides extract of publication-title: Immunopharmacol Immunotoxicol – volume: 11 start-page: 213 year: 2011 end-page: 220 ident: bib8 article-title: Emerging inflammasome effector mechanisms publication-title: Nat Rev Immunol – volume: 35 start-page: 479 year: 2011 end-page: 486 ident: bib4 article-title: Effects of Korean Red Ginseng extract for the treatment of atopic dermatitis-like skin lesions in mice publication-title: J Ginseng Res – volume: 19 start-page: 595 year: 2008 end-page: 600 ident: bib21 article-title: A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells publication-title: Oncol Rep – volume: 7 start-page: 313 year: 2007 end-page: 320 ident: bib20 article-title: Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia publication-title: Int Immunopharmacol – volume: 140 start-page: 821 year: 2010 end-page: 832 ident: bib7 article-title: The inflammasomes publication-title: Cell – volume: 5 start-page: 305 year: 2009 end-page: 311 ident: bib31 article-title: The role of interleukins in insulin resistance and type 2 diabetes mellitus publication-title: Nat Rev Endocrinol – volume: 24 start-page: 93 year: 2004 end-page: 100 ident: bib28 article-title: induces production of proinflammatory cytokines via toll-like receptor publication-title: J Interferon Cytokine Res – volume: 2012 start-page: 732860 year: 2012 ident: bib27 article-title: Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean Red Ginseng publication-title: Mediators Inflamm – volume: 13 start-page: 397 year: 2013 end-page: 411 ident: bib11 article-title: Activation and regulation of the inflammasomes publication-title: Nat Rev Immunol – volume: 76 start-page: 57 year: 2014 end-page: 78 ident: bib32 article-title: Inflammasomes and metabolic disease publication-title: Annu Rev Physiol – volume: 158 start-page: 143 year: 2014 end-page: 150 ident: bib6 article-title: Korean Red Ginseng extracts inhibit NLRP3 and AIM2 inflammasome activation publication-title: Immunol Lett – volume: 67 start-page: 213 year: 2001 end-page: 218 ident: bib19 article-title: In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists publication-title: Planta Med – volume: 356 start-page: 1517 year: 2007 end-page: 1526 ident: bib34 article-title: Interleukin-1-receptor antagonist in type 2 diabetes mellitus publication-title: N Engl J Med – volume: 36 start-page: 119 year: 2012 end-page: 134 ident: bib3 article-title: Recent methodology in ginseng analysis publication-title: J Ginseng Res – volume: 187 start-page: 613 year: 2011 end-page: 617 ident: bib16 article-title: Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome publication-title: J Immunol – volume: 18 start-page: 986 year: 2001 end-page: 991 ident: bib13 article-title: Isolation of saponin-free fraction from Ginseng ( publication-title: Korean J Chem Eng – volume: 22 start-page: 16 year: 2011 end-page: 23 ident: bib33 article-title: Toll-like receptors: linking inflammation to metabolism publication-title: Trends Endocrinol Metab – volume: 24 start-page: 93 year: 2004 ident: 10.1016/j.jgr.2016.10.001_bib28 article-title: Panax ginseng induces production of proinflammatory cytokines via toll-like receptor publication-title: J Interferon Cytokine Res doi: 10.1089/107999004322813336 – volume: 36 start-page: 119 year: 2012 ident: 10.1016/j.jgr.2016.10.001_bib3 article-title: Recent methodology in ginseng analysis publication-title: J Ginseng Res doi: 10.5142/jgr.2012.36.2.119 – volume: 356 start-page: 1517 year: 2007 ident: 10.1016/j.jgr.2016.10.001_bib34 article-title: Interleukin-1-receptor antagonist in type 2 diabetes mellitus publication-title: N Engl J Med doi: 10.1056/NEJMoa065213 – volume: 38 start-page: 193 year: 2014 ident: 10.1016/j.jgr.2016.10.001_bib12 article-title: Characterization of porcine NLRP3 inflammasome activation and its upstream mechanism publication-title: Vet Res Commun doi: 10.1007/s11259-014-9602-5 – volume: 158 start-page: 143 year: 2014 ident: 10.1016/j.jgr.2016.10.001_bib6 article-title: Korean Red Ginseng extracts inhibit NLRP3 and AIM2 inflammasome activation publication-title: Immunol Lett doi: 10.1016/j.imlet.2013.12.017 – volume: 18 start-page: 986 year: 2001 ident: 10.1016/j.jgr.2016.10.001_bib13 article-title: Isolation of saponin-free fraction from Ginseng (Panax ginseng C.A. Meyer) and its effects on the function of neutrophils publication-title: Korean J Chem Eng doi: 10.1007/BF02705630 – volume: 183 start-page: 787 year: 2009 ident: 10.1016/j.jgr.2016.10.001_bib10 article-title: Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression publication-title: J Immunol doi: 10.4049/jimmunol.0901363 – volume: 2012 start-page: 732860 year: 2012 ident: 10.1016/j.jgr.2016.10.001_bib27 article-title: Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean Red Ginseng publication-title: Mediators Inflamm doi: 10.1155/2012/732860 – year: 2016 ident: 10.1016/j.jgr.2016.10.001_bib14 article-title: Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation publication-title: Cell Mol Immunol Forthcoming – volume: 36 start-page: 354 year: 2012 ident: 10.1016/j.jgr.2016.10.001_bib1 article-title: Ginseng, the ‘immunity boost’: the effects of Panax ginseng on immune system publication-title: J Ginseng Res doi: 10.5142/jgr.2012.36.4.354 – volume: 8 start-page: 15 year: 2015 ident: 10.1016/j.jgr.2016.10.001_bib9 article-title: Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives publication-title: J Inflamm Res – volume: 35 start-page: 479 year: 2011 ident: 10.1016/j.jgr.2016.10.001_bib4 article-title: Effects of Korean Red Ginseng extract for the treatment of atopic dermatitis-like skin lesions in mice publication-title: J Ginseng Res doi: 10.5142/jgr.2011.35.4.479 – volume: 187 start-page: 613 year: 2011 ident: 10.1016/j.jgr.2016.10.001_bib16 article-title: Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome publication-title: J Immunol doi: 10.4049/jimmunol.1100613 – volume: 140 start-page: 821 year: 2010 ident: 10.1016/j.jgr.2016.10.001_bib7 article-title: The inflammasomes publication-title: Cell doi: 10.1016/j.cell.2010.01.040 – volume: 7 start-page: 313 year: 2007 ident: 10.1016/j.jgr.2016.10.001_bib20 article-title: Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2006.04.021 – volume: 9 start-page: R28 year: 2007 ident: 10.1016/j.jgr.2016.10.001_bib17 article-title: A pilot study of IL-1 inhibition by anakinra in acute gout publication-title: Arthritis Res Ther doi: 10.1186/ar2143 – volume: 5 start-page: 305 year: 2009 ident: 10.1016/j.jgr.2016.10.001_bib31 article-title: The role of interleukins in insulin resistance and type 2 diabetes mellitus publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2009.62 – volume: 13 start-page: 397 year: 2013 ident: 10.1016/j.jgr.2016.10.001_bib11 article-title: Activation and regulation of the inflammasomes publication-title: Nat Rev Immunol doi: 10.1038/nri3452 – volume: 9 start-page: 23 year: 2015 ident: 10.1016/j.jgr.2016.10.001_bib2 article-title: Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.) publication-title: Drug Discov Ther doi: 10.5582/ddt.2015.01004 – volume: 72 start-page: 1817 year: 2008 ident: 10.1016/j.jgr.2016.10.001_bib26 article-title: Red ginseng acidic polysaccharide (RGAP) in combination with IFN-gamma results in enhanced macrophage function through activation of the NF-kappaB pathway publication-title: Biosci Biotechnol Biochem doi: 10.1271/bbb.80085 – volume: 24 start-page: 469 year: 2002 ident: 10.1016/j.jgr.2016.10.001_bib25 article-title: Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function publication-title: Immunopharmacol Immunotoxicol doi: 10.1081/IPH-120014730 – volume: 22 start-page: 16 year: 2011 ident: 10.1016/j.jgr.2016.10.001_bib33 article-title: Toll-like receptors: linking inflammation to metabolism publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2010.08.007 – volume: 17 start-page: 179 year: 2011 ident: 10.1016/j.jgr.2016.10.001_bib29 article-title: The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance publication-title: Nat Med doi: 10.1038/nm.2279 – volume: 76 start-page: 57 year: 2014 ident: 10.1016/j.jgr.2016.10.001_bib32 article-title: Inflammasomes and metabolic disease publication-title: Annu Rev Physiol doi: 10.1146/annurev-physiol-021113-170324 – volume: 7 start-page: 293 year: 2009 ident: 10.1016/j.jgr.2016.10.001_bib5 article-title: Ginseng compounds: an update on their molecular mechanisms and medical applications publication-title: Curr Vasc Pharmacol doi: 10.2174/157016109788340767 – volume: 205 start-page: 23 year: 2004 ident: 10.1016/j.jgr.2016.10.001_bib22 article-title: 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide publication-title: Cancer Lett doi: 10.1016/j.canlet.2003.09.037 – volume: 45 start-page: 32 year: 2002 ident: 10.1016/j.jgr.2016.10.001_bib24 article-title: Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation publication-title: J Infect – volume: 67 start-page: 213 year: 2001 ident: 10.1016/j.jgr.2016.10.001_bib19 article-title: In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists publication-title: Planta Med doi: 10.1055/s-2001-12005 – volume: 8 start-page: 3682 year: 2009 ident: 10.1016/j.jgr.2016.10.001_bib18 article-title: Anti-inflammatory effects of ginsenosides from Panax ginseng and their structural analogs publication-title: Afr J Biotechnol – volume: 11 start-page: 213 year: 2011 ident: 10.1016/j.jgr.2016.10.001_bib8 article-title: Emerging inflammasome effector mechanisms publication-title: Nat Rev Immunol doi: 10.1038/nri2936 – volume: 24 start-page: 1459 year: 1993 ident: 10.1016/j.jgr.2016.10.001_bib23 article-title: Ginsenoside Rg1 inhibits the brain cAMP phosphodiesterase activity in young and aged rats publication-title: Gen Pharmacol doi: 10.1016/0306-3623(93)90435-Z – volume: 12 start-page: 408 year: 2011 ident: 10.1016/j.jgr.2016.10.001_bib30 article-title: Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling publication-title: Nat Immunol doi: 10.1038/ni.2022 – volume: 584 start-page: 40 year: 2008 ident: 10.1016/j.jgr.2016.10.001_bib15 article-title: TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2008.01.026 – volume: 19 start-page: 595 year: 2008 ident: 10.1016/j.jgr.2016.10.001_bib21 article-title: A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells publication-title: Oncol Rep – reference: 18299127 - Eur J Pharmacol. 2008 Apr 14;584(1):40-8 – reference: 15036657 - Cancer Lett. 2004 Mar 8;205(1):23-9 – reference: 27133472 - Cell Mol Immunol. 2016 May 02;:null – reference: 23717095 - J Ginseng Res. 2011 Nov;35(4):479-86 – reference: 19570822 - J Immunol. 2009 Jul 15;183(2):787-91 – reference: 23717137 - J Ginseng Res. 2012 Oct;36(4):354-68 – reference: 21217695 - Nat Med. 2011 Feb;17 (2):179-88 – reference: 18603775 - Biosci Biotechnol Biochem. 2008 Jul;72(7):1817-25 – reference: 24274736 - Annu Rev Physiol. 2014;76:57-78 – reference: 23702978 - Nat Rev Immunol. 2013 Jun;13(6):397-411 – reference: 21350580 - Nat Rev Immunol. 2011 Mar;11(3):213-20 – reference: 17429083 - N Engl J Med. 2007 Apr 12;356(15):1517-26 – reference: 22474399 - Mediators Inflamm. 2012;2012:732860 – reference: 12375741 - Immunopharmacol Immunotoxicol. 2002 Aug;24(3):469-82 – reference: 21478880 - Nat Immunol. 2011 May;12 (5):408-15 – reference: 25653548 - J Inflamm Res. 2015 Jan 16;8:15-27 – reference: 14980073 - J Interferon Cytokine Res. 2004 Feb;24(2):93-100 – reference: 24418475 - Immunol Lett. 2014 Mar-Apr;158(1-2):143-50 – reference: 19399017 - Nat Rev Endocrinol. 2009 Jun;5(6):305-11 – reference: 18288389 - Oncol Rep. 2008 Mar;19(3):595-600 – reference: 11345690 - Planta Med. 2001 Apr;67(3):213-8 – reference: 21677136 - J Immunol. 2011 Jul 15;187(2):613-7 – reference: 20303873 - Cell. 2010 Mar 19;140(6):821-32 – reference: 17276889 - Int Immunopharmacol. 2007 Mar;7(3):313-20 – reference: 12217729 - J Infect. 2002 Jul;45(1):32-8 – reference: 25788049 - Drug Discov Ther. 2015 Feb;9(1):23-32 – reference: 8112520 - Gen Pharmacol. 1993 Nov;24(6):1459-62 – reference: 19601854 - Curr Vasc Pharmacol. 2009 Jul;7(3):293-302 – reference: 24691785 - Vet Res Commun. 2014 Sep;38(3):193-200 – reference: 20888253 - Trends Endocrinol Metab. 2011 Jan;22(1):16-23 – reference: 23717112 - J Ginseng Res. 2012 Apr;36(2):119-34 – reference: 17352828 - Arthritis Res Ther. 2007;9(2):R28 |
SSID | ssj0067274 |
Score | 2.2416806 |
Snippet | Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties.... Background: Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome... |
SourceID | nrf doaj unpaywall pubmedcentral proquest pubmed crossref nurimedia elsevier |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
StartPage | 513 |
SubjectTerms | cytokine ginsenosides inflammasome inflammasomes interleukin-1beta interleukin-6 Korean Red Ginseng extracts macrophages mice NLRP3 Panax Toll-like receptor 4 기타의약학 |
SummonAdditionalLinks | – databaseName: DOAJ - Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagl8IBlXcoVAZxAgWS2Hn4WKClvBZUUaniYjmOvWy7TVbZXSH-PTN2EjUCbS-cVvLOrh3PZ89ne_KZkOec29RmOgut1SbkiumwKGMW5hXE6lxEiXJael8m2dEJ_3ianl666gtzwrw8sO-41zyFEJXDjJKJgpeqUMBggNNXOdOqsEWJsy-EsX4x5edgPF5058lALsKCp6w_z3SZXWdTFAKNs1curSseRSQn3D8KTNfrFsq36zXK7YPP_kVF_86o3F7XC_X7l5rPL4Wrwx1yq-OZdN8_321yzdR3yM39adtpbZi75McEEKcWuB9LbetfcFjSxtJPDTDJmh6bir6f4d7zlMIUjhZLusD2UTT2e7loP_l8_I1RgCqg60Itmwtzj5wcHnx_exR2Vy2EGuLzKoyVqFTCyyzlXAtjYVUCY5mnoioc6WFxUubCxiY2UWIqXjIdMV5GRsHEnUaW3SdbdVObh4Qm3LLcmoRlQnHOIpHoEhyVsSrVuirKgER9d0vd6ZDjdRhz2SecnUnwkEQPYRF4KCAvhp8svAjHJuM36MPBEPWzXQGgSnaoklehKiC8R4DsqIinGPBXs011PwO0yHM9c9Xi57SR562ExckHMMwgtBQB2RvANLRy8vXdQZQD1xOcBeRpjzAJgx1PcFRtmvVS4p29HNaQYoNNkjFgmYyn0JoHHpVDLQkMPnzkgOQjvI46a_xNPfvpRMeBJxeMQb0vB2Rf7YtH_8MXu-QGGvgMysdka9WuzRNggqtyzw36P_8JVy0 priority: 102 providerName: Directory of Open Access Journals – databaseName: Elsevier Free Content dbid: IXB link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfGXgYPiO91g8kgnkChSew4yeM2NsZXQYNJFS-W49glW5dUaSvEf8-d8yEiUJF4quReYsf3893ZPv9MyHPObWSFFp612nhcMe0lWcC8OAdfHad-qByX3seJOLvg76bRdIscd2dhMK2ytf2NTXfWui0Zt705XhTF-EsQIlMJYEjgxTcBnihnPHaH-KZHnTXGjUa3swzCHkp3O5sux-tyhpSggXjlEryCgW9yFP4DF3WjrKF8p1wj8T5o729B6Z-5lTvrcqF-_lDz-W-O6_QOud1GnPSw-ai7ZMuU98itw1ndsm6Y--TbBLCnFrgyS23dHHVY0srS9xXElCU9Nzl9U-Aq9IyCMUeJJV1g-ygKN6u6KD_5cP6ZUQAt4OxaLatr84BcnJ58PT7z2ksXPA2eeuUFKs1VyDMRca5TY2F-AqOaR2meuPCHBWEWpzYwgfFDk_OMaZ_xzDcKTHjkW_aQbJdVaXYJDbllsTUhE6ninPlpqLPEJoLlkdZ5ko2I33W31C0jOV6MMZdd6tmlBA1J1BAWgYZG5EX_yKKh49gkfIQ67AWRSdsVVPVMtlCSPIInYvBYIk14phIFETLMGfOYaQWNhUbyDgFyAEx4VbGp7meAFnmlC1ct_s4qeVVLmKa8BUEBTiYZkYMeTH0rJ59en_gxRH0pZyPytEOYhGGPezmqNNV6KfH2Xg6zyXSDTCgYxJuMR9CaRw0q-1pCGIb4ySMSD_A66KzhP2Xx3dGPQ8ScMAb1vuyR_W9d7P1fN-6Tm6ieJnvyMdle1WvzBKLAVXbghvkvbntXvQ priority: 102 providerName: Elsevier – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lj9MwELage1g48H6Ux8ogTqBUSew48bHALsurrFZUWvZiOY5duu0mVdsIwa9nJkkjAqsCp0ruJH7M2PONPflMyDPOXeSEEZ5zxnpcM-MlacC8OANfHUs_1BWX3seROBzzdyfRSUMWjd_CdM7vqzysswnSdgZiUCVhQaCzI_AsqUd2xqOj4RcMqABCeAmvGCdDiNA9Lnm8OcG86B0dH1RR9Xdc0eV8CeW7eYkE-6Cli8DnnzmUu2W-0N-_6fn8Fwd1cL1O7VpVvIaYlzIblOt0YH78xvr4T32_Qa41MJUOa7u6SS7Z_Ba5OpwsG6oOe5ucjsBg9QK3c6lb1t9HrGjh6PsCgGhOj21G30xx63pCwQOgxIousLMUheutYJQffTg-YhQsHYzzXK-Kc3uHjA_2P7869JqbGjwD7n3tBVpmOuSpiDg30joIamAp4JHMkgozsSBMY-kCG1g_tBlPmfEZT32rYd2PfMfukl5e5PY-oSF3LHY2ZEJqzpkvQ5MmLhEsi4zJkrRP_I3ulGlozPE2jbna5KudKRg2hcOGRTBsffK8fWRRc3hsE36JBtEKIv12VQCaUc1sVjyCJ2Jwc0ImPNWJBlgNgWYWM6OhsdBIvjEn1SCZGqHAq6bb6n4KpqdmZlpVi7-TQs2WCmKbtyAowDMlfbLXWmbbytGn1_t-DFBRctYnTzbmqmCtwAMgnduiXCm88pdDCCq3yISCAUhlPILW3KtNvK0lhLmLXe6TuGP8ncHq_pNPv1ac5QCzE8ag3hftNPm7Lh78l_RDcgW1UmdaPiK99bK0jwExrtO9Zq34CfvwYaU priority: 102 providerName: Unpaywall |
Title | Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome |
URI | https://dx.doi.org/10.1016/j.jgr.2016.10.001 https://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE07283943 https://www.ncbi.nlm.nih.gov/pubmed/29021698 https://www.proquest.com/docview/1950417493 https://www.proquest.com/docview/2636433451 https://pubmed.ncbi.nlm.nih.gov/PMC5628333 https://doi.org/10.1016/j.jgr.2016.10.001 https://doaj.org/article/452017eb16984ba8a150956d73ca8f8b https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002274267 |
UnpaywallVersion | publishedVersion |
Volume | 41 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
ispartofPNX | Journal of Ginseng Research, 2017, 41(4), , pp.513-523 |
journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2093-4947 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: KQ8 dateStart: 20110101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2093-4947 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: KQ8 dateStart: 20140101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2093-4947 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVESC databaseName: Elsevier Free Content customDbUrl: eissn: 2093-4947 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: IXB dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2093-4947 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: DIK dateStart: 20100101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 2093-4947 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 2093-4947 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: AKRWK dateStart: 20140101 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2093-4947 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: RPM dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 2093-4947 dateEnd: 20250731 omitProxy: true ssIdentifier: ssj0067274 issn: 2093-4947 databaseCode: M48 dateStart: 20110601 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLZ2eRh7QNxXLpVBiAdQpiR2bg8IdbCxUVamiorCi-U4dunWJV3aCvbvOSc3qKgKL63knMSOz2efzz7OOYQ859x4xle-ZYzSFpdMWWHsMCtIwFYHke3KIpbeac8_HvAPQ2-4QWrvedWBs5VLO8wnNcgn-z-vrt_AgH_9-6zW-QhDezr-fnFQy3kxvbIwrxT6X6skG5tkG2yVi7g_5Y2fAd2Qhd8ZSIgVco_Vfs9VT12yXEWA_yUDtpnmUL6TLjAsP-h2FWX9--TlziKdyusfcjL5w6wd3SI3Kz5KOyWAbpMNnd4hu51RXsXk0HfJtx4gU05x35aavPwQYkYzQ7sZMM6U9nVC349xj3pEYapHiRmdYvsoCpd7vijf-9g_YxQ6GVB4KWfZpb5HBkeHn98eW1VKBkuBHZ9bjowS6fLY9zhXkTaweoExz70oCQtyxBw3DiLjaEfbrk54zJTNeGxrCRO8Zxt2n2ylWar3CHW5YYHRLvMjyTmzI1fFoQl9lnhKJWHcInbd3UJV8coxbcZE1AfTzgVoSKCGsAg01CIvm1umZbCOdcIHqMNGEONsFwVZPhLVsBXcgzsCsGd-FPJYhhL4M6wok4ApCY2FRvIaAaKiLCUVgUeN19X9DNAiLtS4qBb_R5m4yAUsYk5A0AcTFLZIuwFT08rep3eHdgCcMOKsRZ7WCBMwKaCnR6Y6W8wE5vblsNaM1si4PgM2yrgHrXlQorKpxYVBiq_cIsESXpc6a_lKOv5eBCcHPh0yBvW-apD9b108_I83eURuoC7Kg5SPydY8X-gnQAjncZtsd7r9L912saECvyfDg3YxzuHKoHfW-foLpMxhqw |
linkProvider | Scholars Portal |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe28VB4QHzTASMgnkChSex8PW5jo2VdQWOTqr1YjmN32bqkSlsh_nvunA8RgYrEUyTnEju-n-9-ti9nQt4xpn0dyMDWWiqbCSrtKHGpHabgq8PY8YTJpXc6CYYX7MvUn26Rw-ZfGAyrrG1_ZdONta5LBnVvDhZZNvjuepipBDAU4ME3brhN7gAbcDCuazQ9aMwx7jSarWWQtlG82do0QV7XM8wJ6gYfTYSX23FOJod_x0dt5yWU9_I1Zt4H9f2Nlf4ZXNlb5wvx84eYz3_zXMcPyP2aclr71Vc9JFsqf0Tu7c_KOu2GekwuJwA-scClWUuX1b8OS6vQ1kkBpDK3zlRqfc5wGXpmgTVHiaW1wPZZKFwt66L8ZHz2jVqAWgDarVgWt-oJuTg-Oj8c2vWpC7YEV72yXRGnwmNJ4DMmY6VhggLDmvlxGhn-Q10vCWPtKlc5nkpZQqVDWeIoATbcdzR9SnbyIlfPieUxTUOtPBrEgjHqxJ5MIh0FNPWlTKOkT5ymu7msU5LjyRhz3sSeXXPQEEcNYRFoqE_et48sqnwcm4QPUIetIKbSNgVFOeM1ljjz4YkQXFYQRywRkQCKDJPGNKRSQGOhkaxBAO8gE16Vbar7LaCF38jMVIvXWcFvSg7zlBEIBuBloj7Za8HUtnLy9dOREwLtixntkzcNwjiMe9zMEbkq1kuOx_cymE7GG2S8gALhpMyH1jyrUNnW4sE4xE_uk7CD105nde_k2ZXJPw6UOaIU6v3QIvvfutj9v258TXrD89MxH48mJy_IXVRVFUr5kuysyrV6BZRwleyZIf8Lqwta3g |
linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lj9MwELage1g48H6Ux8ogTqBUSew48bHALsurrFZUWvZiOY5duu0mVdsIwa9nJkkjAqsCp0ruJH7M2PONPflMyDPOXeSEEZ5zxnpcM-MlacC8OANfHUs_1BWX3seROBzzdyfRSUMWjd_CdM7vqzysswnSdgZiUCVhQaCzI_AsqUd2xqOj4RcMqABCeAmvGCdDiNA9Lnm8OcG86B0dH1RR9Xdc0eV8CeW7eYkE-6Cli8DnnzmUu2W-0N-_6fn8Fwd1cL1O7VpVvIaYlzIblOt0YH78xvr4T32_Qa41MJUOa7u6SS7Z_Ba5OpwsG6oOe5ucjsBg9QK3c6lb1t9HrGjh6PsCgGhOj21G30xx63pCwQOgxIousLMUheutYJQffTg-YhQsHYzzXK-Kc3uHjA_2P7869JqbGjwD7n3tBVpmOuSpiDg30joIamAp4JHMkgozsSBMY-kCG1g_tBlPmfEZT32rYd2PfMfukl5e5PY-oSF3LHY2ZEJqzpkvQ5MmLhEsi4zJkrRP_I3ulGlozPE2jbna5KudKRg2hcOGRTBsffK8fWRRc3hsE36JBtEKIv12VQCaUc1sVjyCJ2Jwc0ImPNWJBlgNgWYWM6OhsdBIvjEn1SCZGqHAq6bb6n4KpqdmZlpVi7-TQs2WCmKbtyAowDMlfbLXWmbbytGn1_t-DFBRctYnTzbmqmCtwAMgnduiXCm88pdDCCq3yISCAUhlPILW3KtNvK0lhLmLXe6TuGP8ncHq_pNPv1ac5QCzE8ag3hftNPm7Lh78l_RDcgW1UmdaPiK99bK0jwExrtO9Zq34CfvwYaU |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nonsaponin+fractions+of+Korean+Red+Ginseng+extracts+prime+activation+of+NLRP3+inflammasome&rft.jtitle=Journal+of+ginseng+research&rft.au=Han%2C+Byung-Cheol&rft.au=Ahn%2C+Huijeong&rft.au=Lee%2C+Jiseon&rft.au=Jeon%2C+Eunsaem&rft.date=2017-10-01&rft.issn=1226-8453&rft.volume=41&rft.issue=4&rft.spage=513&rft_id=info:doi/10.1016%2Fj.jgr.2016.10.001&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1226-8453&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1226-8453&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1226-8453&client=summon |