β-淀粉样蛋白相关性中枢神经系统血管炎

淀粉样脑血管病相关性中枢神经系统血管炎亦称为β-淀粉样蛋白（Aβ）相关性中枢神经系统血管炎,主要表现为存在Aβ沉积的小血管壁或其周围慢性炎症性改变。考虑部分患者临床表现、脑脊液和影像学表现不典型,明确诊断仍需依靠脑组织活检。本文拟就其发病机制、病理学特征、临床表现、治疗及预后等进展进行概述。...

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Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 16; no. 1; pp. 3 - 7
Main Author 李卓 朴月善 卢德宏
Format Journal Article
LanguageChinese
Published 首都医科大学宣武医院病理科, 北京,100053 2016
Subjects
淀粉样β蛋白
病理学
综述
血管炎,中枢神经系统
Pathology
Amyloid beta-protein
血管炎,中枢神经系统
综述
Vasculitis,central nervous system
Review
病理学
淀粉样β蛋白
Online AccessGet full text
ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2016.01.002

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Summary:淀粉样脑血管病相关性中枢神经系统血管炎亦称为β-淀粉样蛋白（Aβ）相关性中枢神经系统血管炎,主要表现为存在Aβ沉积的小血管壁或其周围慢性炎症性改变。考虑部分患者临床表现、脑脊液和影像学表现不典型,明确诊断仍需依靠脑组织活检。本文拟就其发病机制、病理学特征、临床表现、治疗及预后等进展进行概述。
Bibliography:Amyloid beta-protein; Vasculitis; central nervous system; Pathology; Review
LI Zhuo, PIAO Yue-shan, LU De-hong（ Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China）
Amyloid β（Aβ）-related central nervous system（CNS） vasculitis, which is also known ascerebral amyloid angiopathy（CAA）- related CNS vasculitis, is characterized by the presence of chronicinflammation within or around the walls of Aβ-deposit blood vessels. Cerebral biopsy is the gold standardfor diagnosis of Aβ- related CNS vasculitis considering the atypical clinical features, cerebrospinal fluid（CSF） and neuroimaging findings of some patients. This paper reviewed the pathogenesis, neuropathology,clinical features, treatment and prognosis of Aβ-related CNS vasculitis.
12-1363/R
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2016.01.002