胶质瘤分级及分子遗传学标志物相关磁共振成像研究进展

近年来胶质瘤病理学和影像学诊断均有显著进展。胶质瘤分级和分子遗传学标志物既是重要的预后预测因素，又可以指导治疗策略的制定。本文主要介绍应用扩散加权成像、扩散张量成像、扩散峰度成像、动态对比增强磁共振成像、灌注成像和磁共振波谱等新型MRI技术进行胶质瘤分级和分子遗传学标志物检测方面的新进展。分子遗传学标志物联合上述新型MRI技术可以更精确地对胶质瘤进行诊断和分级，并无创性检测胶质瘤分子特征，从而提高对患者预后评价的准确性，更好地指导个体化治疗。...

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Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 17; no. 1; pp. 69 - 73
Main Author 张姗姗 于林
Format Journal Article
LanguageChinese
Published 300052,天津医科大学总医院医学影像科%300070,天津医科大学基础医学院生物化学与分子生物学系 2017
Subjects
生物学标记
磁共振成像
神经胶质瘤
综述
神经胶质瘤
磁共振成像
Glioma
Magnetic resonance imaging
综述
Review
生物学标记
Biological markers
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ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2017.01.013

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Summary:近年来胶质瘤病理学和影像学诊断均有显著进展。胶质瘤分级和分子遗传学标志物既是重要的预后预测因素，又可以指导治疗策略的制定。本文主要介绍应用扩散加权成像、扩散张量成像、扩散峰度成像、动态对比增强磁共振成像、灌注成像和磁共振波谱等新型MRI技术进行胶质瘤分级和分子遗传学标志物检测方面的新进展。分子遗传学标志物联合上述新型MRI技术可以更精确地对胶质瘤进行诊断和分级，并无创性检测胶质瘤分子特征，从而提高对患者预后评价的准确性，更好地指导个体化治疗。
Bibliography:Glioma; Biological markers; Magnetic resonance imaging; Review
ZHANG Shan-shan1, YU Lin2（1Department of Medical Image, Tianjin Medical University General Hospital, Tianjin 300052, China 2Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China）
The pathological and imaging diagnosis of glioma ha~s significantly evolved in recent years. Glioma grading, together with a number of molecular genetic biomarkers, has been recognized as an important prognostic and predictive factor, which can also guide the treatment strategy of glioma. This article highlights the research progress of MRI for noninvasively grading and molecular characterization of gliomas, including diffusion-weighted imaging （DWI）, diffusion tensor imaging （DTI）, diffusion kurtosis imaging （DKI）, dynamic contrast- enhanced MRI （DCE- MRI）, perfusion- weighted imaging （PWI） and magnetic resonance spectroscopy （MRS）. The multiparametric imaging data analysis could improve imaging
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2017.01.013