水通道蛋白4抗体阳性多发性硬化临床特点分析

目的分析水通道蛋白4(AQP4)抗体阳性多发性硬化的临床特征。方法共18例多发性硬化患者,均符合Mc Donald诊断标准(2010年版),分为AQP4抗体阳性组(5例)和AQP4抗体阴性组(13例),并门诊随访。结果 5例AQP4抗体阳性多发性硬化患者,男性2例、女性3例,中位发病年龄43岁,中位病程4个月;脊髓病变和视神经受累常见;MRI显示脑组织广泛多发性长T1、长T2异常信号伴颈胸髓长T1、长T2异常信号(3/5例)或单纯颈胸髓多发性长T1、长T2异常信号(2/5例);脑脊液Ig G指数(4/4例)、24 h Ig G鞘内合成率(3/4例)升高,寡克隆区带阳性(3/4例);血清抗核抗体...

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Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 15; no. 3; pp. 229 - 234
Main Author 何洋\杨亭亭\姜红\向雅娟\敖冬慧\高旭光\刘广志
Format Journal Article
LanguageChinese
Published 100044,北京大学人民医院神经内科%102218,北京清华长庚医院神经内科 清华大学医学中心 2015
Subjects
多发性硬化
水孔蛋白质类
多发性硬化
Multiple sclerosis
水孔蛋白质类
Aquaporins
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ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2015.03.012

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Summary:目的分析水通道蛋白4(AQP4)抗体阳性多发性硬化的临床特征。方法共18例多发性硬化患者,均符合Mc Donald诊断标准(2010年版),分为AQP4抗体阳性组(5例)和AQP4抗体阴性组(13例),并门诊随访。结果 5例AQP4抗体阳性多发性硬化患者,男性2例、女性3例,中位发病年龄43岁,中位病程4个月;脊髓病变和视神经受累常见;MRI显示脑组织广泛多发性长T1、长T2异常信号伴颈胸髓长T1、长T2异常信号(3/5例)或单纯颈胸髓多发性长T1、长T2异常信号(2/5例);脑脊液Ig G指数(4/4例)、24 h Ig G鞘内合成率(3/4例)升高,寡克隆区带阳性(3/4例);血清抗核抗体阳性(2/5例)或合并干燥综合征(1/5例)。结论 AQP4抗体阳性多发性硬化有其特异性,发病机制可能与经典多发性硬化不同,在临床诊断与治疗时需加以重视并区别处理。
Bibliography:HE Yang, YANG Ting-ting, JIANG Hong, XIANG Ya-juan, AO Dong-hui, GAO Xu-guang, LIU Guang-zhi( 1Department of Neurology, Peking University People's Hospital, Beijing 100044, China 2Department of Neurology, Beijing Tsinghua Changgung Hospital; Medical Center, Tsinghua University Beijing 102218, China)
Multiple sclerosis; Aquaporins
Objective To investigate the clinical features of multiple sclerosis(MS) patients with positive serum aquaporin 4(AQP4) antibody.Methods A total of 18 MS patients who had been diagnosed in accord with McDonald Criteria(2010) were enrolled and were divided into AQP4 positive group(N = 5) and AQP4 negative group(N = 13).In combination with accessory examination,clinical features and laboratory data of MS patients were correlatively studied between 2 groups in association with follow-up study in Outpatient Clinic.Results Five seropositive patients,including 2 men and 3 women,were collected.The median age of onset was 43 years and the median clinical course was 4 months.Compared with patie
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2015.03.012