无菌动物的生物学特性及其在人类疾病研究中的应用
微生物学已开始从致病性研究为主转向了生理功能研究为主.正常菌群可促进机体代谢与肠道免疫系统的发育和成熟,也具有保护宿主对抗病原微生物入侵的作用.而研究肠道菌群的生理病理功能对动物模型提出了更高的要求.无菌（germ free,GF）动物的微生物背景清晰,且在解剖与形态学、代谢生理及免疫系统方面与常规实验动物相比有明显的特点,现已成为研究肠道菌群的生理病理功能的最佳动物模型.本文就GF动物在肠道微生态、免疫系统发育、代谢性疾病、药物代谢及肿瘤学等方面的研究进展作一综述....
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| Published in | 复旦学报（医学版） Vol. 42; no. 3; pp. 409 - 412 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
复旦大学附属中山医院胸外科 上海200032
2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-8467 |
| DOI | 10.3969/j.issn.1672-8467.2015.03.022 |
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| Summary: | 微生物学已开始从致病性研究为主转向了生理功能研究为主.正常菌群可促进机体代谢与肠道免疫系统的发育和成熟,也具有保护宿主对抗病原微生物入侵的作用.而研究肠道菌群的生理病理功能对动物模型提出了更高的要求.无菌（germ free,GF）动物的微生物背景清晰,且在解剖与形态学、代谢生理及免疫系统方面与常规实验动物相比有明显的特点,现已成为研究肠道菌群的生理病理功能的最佳动物模型.本文就GF动物在肠道微生态、免疫系统发育、代谢性疾病、药物代谢及肿瘤学等方面的研究进展作一综述. |
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| Bibliography: | CHEN Li,ZHAN Cheng,WANG Lin,JIN Yu-ling,WANG Qun（Department of Thoracic Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China） 31-1885/R The main study of microbiology has begun to shift from pathogenicity to physiological function.Normal flora can not only promote the development and maturation of metabolism and the intestinal immune system,but also has a role in protecting the host against invading pathogens.However,the study of physiological and pathological functions of the intestinal flora puts higher requirements on animal models.Germ free （GF） animal has become the best animal model for the study of physiological and pathological intestinal flora functions,for it has the clear back ground of microbial and the obvious characteristics in anatomy and morphology,physiology and metabolism and immune system compared to conventional laboratory animals.This paper do a review of the following research fields：gut microflora,immune system development,metabolic disorders,drug metabolism and oncology,etc. |
| ISSN: | 1672-8467 |
| DOI: | 10.3969/j.issn.1672-8467.2015.03.022 |