自噬在肝脏细胞中的作用及其受MAPK通路调节的研究进展

自噬是真核生物细胞内一种高度保守的细胞程序,在肝脏的营养和能量代谢中起着重要作用。促进肝细胞自噬,可保护细胞应对外界不良刺激,但若自噬过度,可以引起肝细胞自噬性细胞死亡。肝星状细胞（HSC）是肝纤维化发生、发展过程中一种重要细胞,自噬可为其活化提供能量,但也可能导致其死亡。简述了自噬与肝细胞、HSC的关系;介绍了近年来丝裂原活化蛋白激酶通路与自噬的关系,提出了深入研究肝纤维化过程中自噬与调节通路间的关系,可为研发抗肝纤维化药物提供新靶标的观点。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 32; no. 5; pp. 1009 - 1012
Main Author 姜娜 平键 徐列明
Format Journal Article
LanguageChinese
Published 国家中医药管理局重点研究室(慢性肝病虚损),上海 201203 2016
上海中医药大学肝病研究所,上海 201203%上海中医药大学附属曙光医院,上海 201203
上海市中医临床重点实验室,上海 201203
上海中医药大学肝病研究所,上海 201203
上海中医药大学附属曙光医院,上海 201203
肝肾疾病病证教育部重点实验室,上海 201203
上海市中医临床重点实验室,上海 201203%上海中医药大学附属曙光医院,上海 201203
Subjects
丝裂原激活蛋白激酶类
综述
肝星状细胞
肝硬化
肝细胞
自噬
mitogen-activated protein kinase
自噬
hepatic stellate cells
肝星状细胞
autophagy
肝硬化
丝裂原激活蛋白激酶类
review
肝细胞
综述
liver cirrhosis
hepatocytes
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2016.05.048

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Summary:自噬是真核生物细胞内一种高度保守的细胞程序,在肝脏的营养和能量代谢中起着重要作用。促进肝细胞自噬,可保护细胞应对外界不良刺激,但若自噬过度,可以引起肝细胞自噬性细胞死亡。肝星状细胞（HSC）是肝纤维化发生、发展过程中一种重要细胞,自噬可为其活化提供能量,但也可能导致其死亡。简述了自噬与肝细胞、HSC的关系;介绍了近年来丝裂原活化蛋白激酶通路与自噬的关系,提出了深入研究肝纤维化过程中自噬与调节通路间的关系,可为研发抗肝纤维化药物提供新靶标的观点。
Bibliography:JIANG Na, PING Jian, XU Lieming. （ Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China）
Autophagy is a highly conservative cellular process in eukaryotes that plays an important role in nutrition and energy metabolism in the liver. It can promote the autophagy of hepatocytes and protect the hepatocytes against the adverse external stimulation,but excessive autophagy can cause autophagic cell death of hepatocytes. Hepatic stellate cells（ HSC） play an important role in the development and progression of liver fibrosis. Autophagy can provide energy for their activation,but may also lead to their death. This article introduces the relationship of autophagy with hepatocytes / HSC and the mitogen- activated protein kinase pathway,and points out that in- depth studies on the relationship between autophagy and pathway regulation during liver fibrosis can provide new targets for developing antifibrotic drugs.
autophagy; liver cirrhosis; hepatocytes; hepatic stellat
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2016.05.048