慢性乙型肝炎与IFNγ、IL-4的关系

慢性乙型肝炎（CHB）的发病机制主要是机体免疫功能特异性损伤,最终导致HBV感染的慢性化。现代研究表明,激活的特异性炎症细胞及其所释放的细胞因子IFNγ、IL-4,在病毒清除及提高机体自身免疫功能方面发挥重要作用。随着祖国医学的不断发展,中医药对免疫调控系统（特别是IFNγ、IL-4等）也产生广泛的影响。就近年来中西医有关CHB免疫机制研究进展进行阐述,为中医药从免疫调控角度打破CHB的免疫耐受提供新的思路和对策。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 32; no. 10; pp. 1989 - 1993
Main Author 翁美玲 张国梁 吴文泽 施美 刘丽丽
Format Journal Article
LanguageChinese
Published 安徽中医药大学,合肥,230031%安徽中医药大学第一附属医院,合肥,230031 2016
Subjects
免疫疗法
干扰素Ⅱ型
白细胞介素4
综述
肝炎,乙型,慢性
白细胞介素4
interleukin-4
免疫疗法
肝炎,乙型,慢性
review
immunotherapy
interferon type
综述
干扰素Ⅱ型
hepatitis B,chronic
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2016.10.039

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Summary:慢性乙型肝炎（CHB）的发病机制主要是机体免疫功能特异性损伤,最终导致HBV感染的慢性化。现代研究表明,激活的特异性炎症细胞及其所释放的细胞因子IFNγ、IL-4,在病毒清除及提高机体自身免疫功能方面发挥重要作用。随着祖国医学的不断发展,中医药对免疫调控系统（特别是IFNγ、IL-4等）也产生广泛的影响。就近年来中西医有关CHB免疫机制研究进展进行阐述,为中医药从免疫调控角度打破CHB的免疫耐受提供新的思路和对策。
Bibliography:The pathogenesis of chronic hepatitis B（ CHB） is mainly chronicity of hepatitis B virus infection caused by specific immune impairment. Modern studies have shown that activated specific inflammatory cells and the cytokines released by these cells such as interferon-γ（ IFN-γ） and interleukin-4（ IL-4） play important roles in virus clearance and improvement of autoimmune function. With the constant development of traditional Chinese medicine,it has a widespread effect on the immune regulation system（ especially IFN-γ and IL-4）. This article reviews the research advances in immunologic mechanism if CHB in Chinese and Western medicine in recent years and provides new ideas and measures for traditional Chinese medicine to break the immune tolerance of CHB in terms of immune regulation.
hepatitis B; chronic; immunotherapy; interferon type Ⅱ; interleukin-4; review
WENG Meiling, ZHANG Guoliang, WU Wenze, et al. （ Anhui University of Chinese Medicine, Hefei 230031, China）
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2016.10.039