Effect of ovary lipid of skipjack tuna on rat serum components after stress application

• Published in: Journal of Veterinary Medical Science Vol. 69; no. 1; pp. 49 - 54
• Main Authors: Ookawa, K.(Shizuoka-ken. Industrial Research Inst. (Japan)), Mochizuki, K, Sugimoto, Y, Suzuki, T, Hashizume, M, Kitagawa, T, Matumoto, T, Ito, C, Yokogoshi, H
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2007; Japan Science and Technology Agency
• Subjects: ACIDE DOCOSAHEXAENOIQUE; ACIDO DOCOSAHEXAENOICO; ANDROGENE; ANDROGENOS; ANDROGENS; Animals; Body Weight; corticosterone; Corticosterone - blood; dehydroepiandrosterone; Dehydroepiandrosterone - blood; DOCOSAHEXAENOIC ACID; Docosahexaenoic Acids - isolation & purification; Docosahexaenoic Acids - pharmacology; Docosahexaenoic Acids - therapeutic use; Eating - drug effects; ESTRES; Female; GLUCOCORTICOIDE; GLUCOCORTICOIDES; GLUCOCORTICOIDS; KATSUWONUS PELAMIS; LIPIDE; LIPIDOS; LIPIDS; Male; Marine; OVAIRE; OVARIES; OVARIOS; Ovary - chemistry; Ovary lipid; RAT; RATA; RATS; Rats, Wistar; Statistics, Nonparametric; STRESS; Stress, Physiological - drug therapy; Thunnus; Tuna
• ISSN: 0916-7250; 1347-7439; 1347-7439
• DOI: 10.1292/jvms.69.49

Lipid extracted from the ovary of skipjack tuna by the method that we developed is rich in phospholipid-type docosahexaenoic acid. The ovary lipid of skipjack tuna (OLS) was studied for its anti-stress activity in male Wistar rats, focusing on stress-related blood components: recovery from stress was examined after application of water immersion restraint stress. As a result, serum corticosterone (CORT) secretion was inhibited and decreased rapidly after stress application in rats given OLS compared with control rats. As CORT acts as a glucocorticoid, non-esterified fatty acid (NEFA) is expected to increase by stress application. However, the concentration tended to be lower in rats given OLS than in control rats. With respect to OLS concentration, OLS increased serum dehydroepiandrosterone secretion, OLS concentration-dependently. In addition, as with the recovery study, it tended to inhibit the increase in NEFA. These results indicate that OLS may have an anti-stress activity against acute stress.