Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis

• Published in: Saudi journal of gastroenterology Vol. 24; no. 3; pp. 141 - 150
• Main Authors: Wang, Ben, Duan, Ruqiao, Duan, Liping
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.05.2018; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Bias; Complications and side effects; Demographic aspects; Female; Gastroenterology; Humans; Insomnia; Irritable bowel syndrome; Irritable Bowel Syndrome - complications; Male; Meta-analysis; Microbiota; Nervous system; Odds Ratio; Prevalence; Prognosis; Quality; Risk factors; Sensitivity analysis; sleep disorder; Sleep disorders; Sleep Wake Disorders - epidemiology; Studies; Systematic review; Systematic Review/Meta-analysis; Womens health; Saudi Arabia; Middle East; Beijing China; East Asia; Southeast Asia; Asia; South Asia; meta-analysis; prevalence; sleep disorder; Irritable bowel syndrome
• ISSN: 1319-3767; 1998-4049; 1998-4049
• DOI: 10.4103/sjg.SJG_603_17

Background/Aims: We conducted this meta-analysis to evaluate the prevalence of sleep disorder in irritable bowel syndrome (IBS) patients and study the association between IBS and sleep disorder. Materials and Methods: A systematic search was conducted by searching PubMed, Embase, and Cochrane library databases using the following search terms: "functional gastrointestinal disorders," "Sleep disturbance," "Sleep disorder," "insomnia," "Dysomnias," "irritable bowel syndrome," and "IBS." Studies evaluating the association between IBS and sleep disorder were identified. Data analysis was conducted using meta-analysis software Comprehensive Meta-Analysis (CMA) 2.0. Heterogeneity across studies was evaluated by χ2and I2statistics. Publication bias was evaluated by funnel plot, Begg's test, and Egger's test. Sensitivity analysis was also performed by removing each single study separately. Results: The bibliographical search yielded a total of 2866 studies. Finally, 36 studies including 63620 participants were identified. The prevalence of sleep disorder in IBS was 37.6% (95% CI: 31.4% to 44.3%) based on this meta-analysis. The pooled odds ratio was 2.618 (95% CI: 2.052% to 3.341). Publication bias was not determined. Regarding the sensitivity analysis, the outcome was stable regardless of which study was removed. Conclusions: The prevalence of sleep disorder was higher in IBS compared to healthy controls and may be associated with the pathogenesis of IBS. The prevalence of sleep disorder in IBS may differ according to different areas, age, gender, occupation, and IBS diagnostic criteria. Further studies are needed to investigate any possible causal relationship between sleep disorder and IBS.