Hypertension is associated with osteoporosis: a case-control study in Chinese postmenopausal women

• Published in: BMC musculoskeletal disorders Vol. 22; no. 1; pp. 253 - 7
• Main Authors: Chai, Hao, Ge, Jirong, Li, Li, Li, Jianyang, Ye, Yunjin
• Format: Journal Article
• Language: English
• Published: London BioMed Central 07.03.2021; BioMed Central Ltd; BMC
• Subjects: Absorptiometry, Photon; Age; Ankle; Association; Blood pressure; Bone Density; Bone loss; Bone mineral density; Calcification; Cardiology; Cardiovascular disease; Cardiovascular diseases; Case-Control Studies; Cerebral infarction; China - epidemiology; Complications and side effects; Coronary artery disease; Diabetes; Dual energy X-ray absorptiometry; Epidemiology; Female; Health aspects; Heart; Heart diseases; Humans; Hypertension; Hypertension - diagnosis; Hypertension - epidemiology; Internal Medicine; Medical records; Medicine; Medicine & Public Health; Metabolism; Musculoskeletal diseases; Myocardial infarction; Orthopedics; Osteoporosis; Osteoporosis - diagnostic imaging; Osteoporosis - epidemiology; Osteoporosis, Postmenopausal - diagnostic imaging; Osteoporosis, Postmenopausal - epidemiology; Patients; Post-menopause; Postmenopausal women; Postmenopause; Questionnaires; Regression analysis; Rehabilitation; Research Article; Retrospective Studies; Rheumatology; Risk factors; Sports Medicine; Statistics; Tumor necrosis factor-TNF; Womens health; China; United States > US; Hypertension; Osteoporosis; Cardiovascular disease; Bone mineral density; Association
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-021-04124-9

Background Osteoporosis and cardiovascular disease (CVD) are age-related diseases. It is reported that patients with CVD have a higher risk of bone loss. This retrospective study sought to reveal the association between osteoporosis and CVD in Chinese women. Although epidemiological evidence has indicated a relationship between the two, clinical data in southeast China are lacking. Methods In total, 2873 participants completed the baseline survey from January 2007 to October 2019, and 2039 were included in this retrospective study. We divided all subjects into an osteoporosis group and a non-osteoporosis group based on their bone mineral density (BMD). Dual-energy X-ray absorptiometry (DXA) was used to examine BMD. The general information came from the questionnaire survey. Cardiovascular diseases were defined by asking participants at the first visit and checking relevant medical records if they had suffered from hypertension, coronary heart disease, or cerebral infarction. Results According to the criterion, the osteoporosis group had 678 subjects, and the non-osteoporosis group had 1361 subjects. Subjects in the osteoporosis group had a significantly higher prevalence of hypertension and coronary heart disease. Besides, the proportion of subjects who drank tea and drank milk were relatively higher in the osteoporosis group. The odds ratio (OR) for suffering from osteoporosis was high if the patients had hypertension. Conclusions This study indicated that Chinese postmenopausal women with osteoporosis had a higher prevalence of hypertension. Hypertension was significantly associated with osteoporosis.