Serum and urine ANGPTL8 expression levels are associated with hyperlipidemia and proteinuria in primary nephrotic syndrome

• Published in: BMC nephrology Vol. 22; no. 1; pp. 130 - 7
• Main Authors: Li, Yue, Liu, Qingju, Kang, Chengdong, Cui, Weijing, Xu, Zichuan, Zhong, Fu, Gao, Xia
• Format: Journal Article
• Language: English
• Published: London BioMed Central 14.04.2021; BioMed Central Ltd; Springer Nature B.V; BMC
• Subjects: Adult; Angiopoietin-Like Protein 8 - blood; Angiopoietin-Like Protein 8 - urine; Automation; Biomarkers - blood; Biomarkers - urine; Biopsy; Blood pressure; Case-Control Studies; Cholesterol; Complications and side effects; Creatinine; Cross-Sectional Studies; Disease; Edema; Enzyme-linked immunosorbent assay; Epidermal growth factor receptors; Female; Females; Glomerulonephritis; Health aspects; Humans; Hyperlipidemia; Hyperlipidemias - etiology; Internal Medicine; Kidney diseases; Kidneys; Lipids; Lipids - blood; Male; Males; Medical laboratories; Medicine; Medicine & Public Health; Membranous nephropathy; Metabolism; Nephrology; Nephropathy; Nephrotic syndrome; Nephrotic Syndrome - complications; Nephrotic Syndrome - metabolism; Pathology; Patients; Peptide hormones; Peptide Hormones - blood; Peptide Hormones - urine; Proteins; Proteinuria; Proteinuria - etiology; Risk factors; Triglycerides; Ultrasonic imaging; Urine; China; United States > US
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-021-02350-w

Background This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria. Methods ANGPTL8 levels were determined using an enzyme-linked immunosorbent assay in 133 subjects with PNS and 60 healthy controls. Results Compared with healthy controls, subjects with primary nephrotic syndrome had higher levels of serum and urine ANGPTL8 ( P  < 0.001). In primary nephrotic syndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r = 0.209, P  < 0.05) and triglycerides (r = 0.412, P  < 0.001), while there was no correlation with 24 hUTP. Urine ANGPTL8 was positively correlated with high-density lipoprotein cholesterol (r = 0.181, P  < 0.05) and was significantly negatively correlated with creatinine (r = − 0.323, P  < 0.001), eGFR (r = − 0, P  < 0.001) and 24 hUTP (r = − 0.268, P  = 0.002). Interestingly, the urine ANGPTL8 concentrations in membranous nephropathy and mesangial proliferative glomerulonephritis pathological types were different. Conclusions Serum and urine ANGPTL8 levels in primary nephrotic syndrome patients were correlated with blood lipid levels and proteinuria, respectively, suggesting that ANGPTL8 may play a role in the development of primary nephrotic syndrome hyperlipidemia and proteinuria.