骨形态发生蛋白7/Smads信号通路及其在肝纤维化进程中的作用

肝纤维化是由于各种病因导致肝损伤后,机体对损伤进行修复的过程。近年来研究发现骨形态发生蛋白（BMP）7及其下游的Smads蛋白可以通过不同的途径拮抗转化生长因子（TGF）β1的致肝纤维化作用,包括诱导细胞外基质降解,抑制细胞凋亡,减少多种促炎症因子的表达,促进肝细胞再生等,探讨了BMP-7/Smads信号通路在肝纤维化过程中的作用。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 32; no. 5; pp. 1001 - 1004
Main Author 侯斐 刘瑞霞 阴赪宏
Format Journal Article
LanguageChinese
Published 首都医科大学附属北京友谊医院 感染内科,北京,100050%首都医科大学附属北京妇产医院 内科,北京,100026 2016
Subjects
Smad蛋白质类
综述
肝硬化
转化生长因子β1
骨形态发生蛋白质类
骨形态发生蛋白质类
肝硬化
Smad蛋白质类
review
Smad proteins
transforming growth factor beta1
综述
转化生长因子B1
liver cirrhosis
bone morphogenetic proteins
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2016.05.046

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Summary:肝纤维化是由于各种病因导致肝损伤后,机体对损伤进行修复的过程。近年来研究发现骨形态发生蛋白（BMP）7及其下游的Smads蛋白可以通过不同的途径拮抗转化生长因子（TGF）β1的致肝纤维化作用,包括诱导细胞外基质降解,抑制细胞凋亡,减少多种促炎症因子的表达,促进肝细胞再生等,探讨了BMP-7/Smads信号通路在肝纤维化过程中的作用。
Bibliography:Hepatic fibrosis is the process in which the human body repairs the liver tissue damaged due to various reasons. Recent studies have found that bone morphogenetic protein- 7（ BMP- 7） and the downstream Smads can antagonize the effect of transforming growth factor- β1,which induces hepatic fibrosis,through various pathways,including inducing the degradation of extracellular matrix,inhibiting cell apoptosis,reducing the expression of various proinflammatory factors,and promoting the regeneration of hepatocytes. This article investigates the role of BMP- 7 / Smads signaling pathway in hepatic fibrosis.
HOU Fei, LIU Ruixia, YIN Chenghong. （Department of Infection, Beijing Friendship Haspital, Capital Medical University, Beijing 100050, China）
liver cirrhosis; bone morphogenetic proteins; Smad proteins; transforming growth factor beta1; review
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2016.05.046