血液透析患者脂代谢现况调查及影响因素分析

的:评估单中心血液透析患者脂代谢现况,并探讨相关危险因素。方法:以复旦大学附属中山医院血液净化中心维持性血液透析3个月以上的患者为研究对象进行横断面调查。所有患者均空腹检测三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)、血清白蛋白等指标,并进行透析充分性评估。同时收集患者一般情况、病史资料。结果:03例患者平均丁C为(4.45±1.16)mmol/L、TG193±2.18)mmol/L、HDL-C(.16±0.34)mmol/L、LDL-C251±0.93)mmol/L。其中,132例患者(65%)存在至少1项...

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Published in中国临床医学 Vol. 24; no. 5; pp. 705 - 709
Main Author 王莉;高健;沈波;丁小强;吕文律;曹学森;刘中华;滕杰;邹建洲
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院肾内科,上海市肾脏疾病与血液净化重点实验室,上海市肾病与透析研究所,上海200032%江苏省海安县人民医院肾内科,南通,226600 2017
Subjects
血液透析;脂质代谢;横断面研究;危险因素
risk factors
脂质代谢
危险因素
lipid metabolism
hemodialysis
cross-sectional study
横断面研究
血液透析
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ISSN1008-6358
DOI10.12025/j.issn.1008-6358.2017.20170037

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Summary:的:评估单中心血液透析患者脂代谢现况,并探讨相关危险因素。方法:以复旦大学附属中山医院血液净化中心维持性血液透析3个月以上的患者为研究对象进行横断面调查。所有患者均空腹检测三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)、血清白蛋白等指标,并进行透析充分性评估。同时收集患者一般情况、病史资料。结果:03例患者平均丁C为(4.45±1.16)mmol/L、TG193±2.18)mmol/L、HDL-C(.16±0.34)mmol/L、LDL-C251±0.93)mmol/L。其中,132例患者(65%)存在至少1项血脂异常。女性患者血清高丁C和高LDL-C比例高于男性,低HDL-C比例低于男性(P<0.05)。年龄>60岁组患者血清TG水平高于年龄<45岁组和45?59岁组;年龄<45岁组患者血脂异常比例最高(P<0.05)。透析龄>60个月组患者丁G异常比例低于透析龄<12个月组和透析龄12?60个月组;透析龄<12个月组患者丁G异常比例最高(P<0.05)。HbA1c<6%组丁G水平低于HbA1c>6%组;HbA1c<6%组患者血脂异常比例低于HbA1c>6%组(P<0.05)。结论:维持性血液透析患者脂代谢紊乱发生率高;女性、年龄<45岁、透析龄<12个月、HbA1c>6%是维持性血液透析患者脂代谢异常的危险因素。
Bibliography:31-1794/R
hemodialysis; lipid metabolism; cross sectional study; risk factors
Objective:To investigate the lipid levels of maintenance hemodialysis(MHD)patients from single center and to explore the related risk factors.Methods:MHD patients(dialysis duration>3months)in blood purification center of Zhongshan Hospital,Fudan University were enrolled in the research.Fasting blood lipid including triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL C),low density lipoprotein cholesterol(LDL C),glycosylated hemoglobin(HbA1c),serum albumin and other indicators were tested,and dialysis adequacy evaluation was made.At the same time,patients’general information and medical history were collected.Results:The average levels of TC,TG,HDL C and LDL C in203patients were(4.45±1.16)mmol/L,(1.93±2.18)mmol/L,(1.16±0.34)mmol/L,(2.51±0.93)mmol/L,respectively.132patients(65%)were bothered by lipid abnormalities.Proportions of serum high TC and LDL C abnormality were higher in women than in men while low
ISSN:1008-6358
DOI:10.12025/j.issn.1008-6358.2017.20170037