Circular RNA is enriched and stable in exosomes： a promising biomarker for cancer diagnosis

Circular RNAs （circRNAs） are recently identified as a naturally occurring family of widespread and diverse endogenous noncoding RNAs that may regulate gene expression in mammals . They are unusually sta- ble RNA molecules with cell type- or developmental stage-specific expression patterns . Exosomes...

Full description

Saved in:

Bibliographic Details
Published in	Cell research Vol. 25; no. 8; pp. 981 - 984
Main Authors	Li, Yan, Zheng, Qiupeng, Bao, Chunyang, Li, Shuyi, Guo, Weijie, Zhao, Jiang, Chen, Di, Gu, Jianren, He, Xianghuo, Huang, Shenglin
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.08.2015 Nature Publishing Group
Subjects	631/45/500 631/80 692/53/2421 692/699/67 Animals Biomarkers, Tumor Biomedical and Life Sciences Cell Biology Early Detection of Cancer - methods Exosomes - metabolism Humans Letter to the Editor Life Sciences Neoplasms, Experimental - diagnosis Neoplasms, Experimental - genetics RNA - analysis RNA - genetics 发育阶段特异性循环生物标志物癌症稳定细胞类型诊断非编码RNA
Online Access	Get full text
ISSN	1001-0602 1748-7838 1748-7838
DOI	10.1038/cr.2015.82

Cover

More Information
Summary:	Circular RNAs （circRNAs） are recently identified as a naturally occurring family of widespread and diverse endogenous noncoding RNAs that may regulate gene expression in mammals . They are unusually sta- ble RNA molecules with cell type- or developmental stage-specific expression patterns . Exosomes are small membrane vesicles of endocytic origin secreted by most cell types. They contain a specific cargo of protein, mRNA and microRNA species, which can modulate recipient cell behaviors and may be used as biomarkers for diagnosis of human diseases .
Bibliography:	31-1568 Circular RNAs （circRNAs） are recently identified as a naturally occurring family of widespread and diverse endogenous noncoding RNAs that may regulate gene expression in mammals . They are unusually sta- ble RNA molecules with cell type- or developmental stage-specific expression patterns . Exosomes are small membrane vesicles of endocytic origin secreted by most cell types. They contain a specific cargo of protein, mRNA and microRNA species, which can modulate recipient cell behaviors and may be used as biomarkers for diagnosis of human diseases . ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-2 content type line 23 These two authors contributed equally to this work.
ISSN:	1001-0602 1748-7838 1748-7838
DOI:	10.1038/cr.2015.82