Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia

There are 3 isoforms of apolipoprotein E (apo E) in humans (ε2, ε3, and ε4). They differ by single amino acid substitutions that variably affect their affinity for the low-density lipoprotein receptor (LDLR) and for the LDLR-related protein (LRP1), with ε2 having the weakest binding to these recepto...

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Published inJACC. Basic to translational science Vol. 4; no. 3; pp. 425 - 427
Main Authors Blanchard, Valentin, Croyal, Mikaël, Khantalin, Ilya, Ramin-Mangata, Stéphane, Chemello, Kévin, Nativel, Brice, Blom, Dirk. J., Marais, A. David, Lambert, Gilles
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2019
Elsevier on behalf of the American College of Cardiology Foundation
Elsevier
Subjects
Cardiovascular
LETTER
Life Sciences
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ISSN2452-302X
2452-302X
DOI10.1016/j.jacbts.2019.03.002

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Summary:There are 3 isoforms of apolipoprotein E (apo E) in humans (ε2, ε3, and ε4). They differ by single amino acid substitutions that variably affect their affinity for the low-density lipoprotein receptor (LDLR) and for the LDLR-related protein (LRP1), with ε2 having the weakest binding to these receptors (1). The plasma levels of lipoprotein(a) [Lp(a)], a highly atherogenic LDL-like lipoprotein species, are influenced by the polymorphism of apo E, with ε2/ε2 and ε4/ε4 carriers presenting with the lowest and highest Lp(a) plasma concentrations, respectively (1).
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ISSN:2452-302X
2452-302X
DOI:10.1016/j.jacbts.2019.03.002