水飞蓟宾治疗药物性肝损伤的研究进展

药物性肝损伤是临床上常见的肝损伤类型,抗精神病类药物、抗结核药物、对乙酰氨基酚、他汀类药物等均可能引起药物性肝损伤。水飞蓟宾作为水飞蓟素提取物中最具生物活性的物质,具有抗氧化、抗炎、抗纤维化等作用,总结了水飞蓟宾在防治药物性肝损伤方面的研究进展。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 33; no. 6; pp. 1179 - 1182
Main Author 邵爽 刘春燕 高沿航
Format Journal Article
LanguageChinese
Published 吉林大学第一医院肝病科,长春,130021 2017
Subjects
水飞蓟素
综述
药物性肝损伤
drug induced liver injury
silymarin
药物性肝损伤
综述
水飞蓟素
review
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2017.06.035

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Summary:药物性肝损伤是临床上常见的肝损伤类型,抗精神病类药物、抗结核药物、对乙酰氨基酚、他汀类药物等均可能引起药物性肝损伤。水飞蓟宾作为水飞蓟素提取物中最具生物活性的物质,具有抗氧化、抗炎、抗纤维化等作用,总结了水飞蓟宾在防治药物性肝损伤方面的研究进展。
Bibliography:drug induced liver injury; silymarin; review
Drug-induced liver injury is commonly seen in clinical practice and is usually caused by antipsychotic drugs,antitubercular agents,paracetamol,and statins. Silybin,a substance with biological activity in silymarin extract,has antioxidant,anti-inflammatory,and anti-fibrosis effects. This article summarizes the research advances in silybin in the prevention and treatment of drug-induced liver injury.
SHAO Shuang, LIU Chunyan, GAO Yanhang. （Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China）
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2017.06.035