Serum Concentrations of Vascular Endothelial Growth Factor and Monocyte-Colony Stimulating Factor in Peripheral Arterial Disease

• Published in: Circulation Journal Vol. 67; no. 8; pp. 660 - 662
• Main Authors: Ikeda, Uichi, Matsui, Keiji, Murakami, Yoshiaki, Yoshioka, Toru, Takahashi, Masafumi, Shimada, Kazuyuki
• Format: Journal Article
• Language: English
• Published: Kyoto The Japanese Circulation Society 2003; Japanese Circulation Society
• Subjects: Angiogenesis; Arteriosclerosis Obliterans - blood; Atherosclerosis; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Case-Control Studies; Cytokine; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Humans; Inflammation; Macrophage Colony-Stimulating Factor - blood; Male; Medical sciences; Middle Aged; Osmolar Concentration; Thromboangiitis Obliterans - blood; Vascular Endothelial Growth Factor A - blood; Human; Monocyte; Pathogenesis; Cytokine; Cardiovascular disease; Inflammation; Colony stimulating factor; Arterial disease; Vascular disease; Angiogenesis; Vascular endothelium growth factor; Atherosclerosis; Occlusive arterial disease; Serum
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.67.660

Vascular endothelial growth factor (VEGF) strongly promotes angiogenesis, and monocyte-colony stimulating factor (M-CSF) regulates the differentiation, proliferation, and survival of monocytes. Both VEGF and M-CSF are expressed in atherosclerotic lesions. The present study was performed to clarify the role of VEGF and M-CSF in the development of peripheral artery disease (PAD). The serum VEGF and M-CSF concentrations were determined in patients with arteriosclerosis obliterans (ASO) and thromboangitis obliterans (TAO). In both patient groups the serum VEGF concentrations were significantly higher than those in the control subjects. In contrast, the serum M-CSF concentrations in the ASO patients were significantly higher than those in both the TAO patients and control subjects, but there were no differences in the M-CSF concentrations between the TAO patients and control subjects. There was no correlation between the serum concentrations of VEGF and M-CSF. In conclusion, the serum VEGF concentration was increased in ASO and TAO patients, but increased concentration of M-CSF was seen only in ASO patients. These results may reflect a difference between ASO and TAO in disease pathogenesis. (Circ J 2003; 67: 660 - 662)