自噬与肝再生关系的研究进展
自噬是细胞内的一种降解途径,通过形成自噬泡将细胞内生物大分子和受损细胞器运送至溶酶体进行降解,在维持肝脏功能的动态平衡中发挥着重要作用,肝脏通过自噬可消除异常肝细胞。回顾了自噬和肝细胞、非实质肝细胞以及肝干细胞增殖的密切关系,分析表明自噬可通过促进肝细胞、肝干细胞的增殖从而恢复肝脏的体积和功能,并能够适时终止,防止肿瘤的发生;而功能失调时,自噬可能通过增强非实质肝细胞的活化,进而抑制肝细胞再生,同时导致纤维化的发生和发展;肿瘤形成阶段,自噬在正常细胞向癌细胞转化的过程中发挥重要作用,肝细胞恶性再生被激活但不能适时终止。...
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| Published in | 临床肝胆病杂志 Vol. 32; no. 9; pp. 1827 - 1831 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
首都医科大学附属北京佑安医院人工肝中心,北京,100069%北京市肝病研究所,北京,100069
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2016.09.044 |
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| Summary: | 自噬是细胞内的一种降解途径,通过形成自噬泡将细胞内生物大分子和受损细胞器运送至溶酶体进行降解,在维持肝脏功能的动态平衡中发挥着重要作用,肝脏通过自噬可消除异常肝细胞。回顾了自噬和肝细胞、非实质肝细胞以及肝干细胞增殖的密切关系,分析表明自噬可通过促进肝细胞、肝干细胞的增殖从而恢复肝脏的体积和功能,并能够适时终止,防止肿瘤的发生;而功能失调时,自噬可能通过增强非实质肝细胞的活化,进而抑制肝细胞再生,同时导致纤维化的发生和发展;肿瘤形成阶段,自噬在正常细胞向癌细胞转化的过程中发挥重要作用,肝细胞恶性再生被激活但不能适时终止。 |
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| Bibliography: | HAN Weifia, Sill Hongbo, CHEN Yu. （ Artificial Liver Treatment ＆ Training Center, Beifing YouAn Hospital, Capital Medical University, Beifing 100069, China） liver regeneration; autophagy; review Autophagy is a pathway of intracellular degradation,in which autophagic vacuoles are formed to transport intracellular biomacromolecules and damaged organelles to lysosomes. Autophagy plays an important role in the maintenance of the dynamic balance of liver function. Abnormal liver cells can be eliminated by autophagy. This article reviews the close relationship of autophagy with the proliferation of liver cells,non- parenchymal liver cells,and hepatic stem cells. Analysis has shown that autophagy may restore the volume and function of the liver by promoting the proliferation of liver cells and hepatic stem cells,which can be stopped in time to prevent tumor development. Autophagy may promote the activation of non- parenchymal liver cells during liver dysfunction,which can inhibit the regeneration of liver cells,and,in |
| ISSN: | 1001-5256 |
| DOI: | 10.3969/j.issn.1001-5256.2016.09.044 |