维生素D及其受体在肝硬化病情评估及治疗中的作用

肝脏是维生素D产生的主要场所,不同病因所致的慢性肝损伤,终会影响维生素D代谢而导致维生素D缺乏,从而加速肝病本身的进展。近期研究证实,肝硬化患者体内维生素D缺乏程度与肝硬化的严重程度、并发症的发生关系密切。介绍了维生素D及其受体在肝硬化病情评估及治疗中的作用,指出维生素D不仅有助于评估肝硬化病情的严重程度,也有可能作为肝硬化治疗的新切入点并成为重要的辅助药物。...

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Published in	临床肝胆病杂志 Vol. 32; no. 8; pp. 1617 - 1621
Main Author	诸炳骅徐列明
Format	Journal Article
Language	Chinese
Published	上海市中医临床重点实验室,上海201203 2016 上海中医药大学附属曙光医院,上海201203 上海中医药大学肝病研究所,上海201203%上海中医药大学附属曙光医院,上海201203 国家中医药管理局重点研究室(慢性肝病虚损),上海201203 上海中医药大学肝病研究所,上海201203 肝肾疾病病证教育部重点实验室,上海201203
Subjects	受体,骨化三醇维生素D 综述肝硬化 receptor,calcitriol 维生素D 受体,骨化三醇肝硬化 vitamin D review 综述 liver cirrhosis
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ISSN	1001-5256
DOI	10.3969/j.issn.1001-5256.2016.08.044

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Summary:	肝脏是维生素D产生的主要场所,不同病因所致的慢性肝损伤,终会影响维生素D代谢而导致维生素D缺乏,从而加速肝病本身的进展。近期研究证实,肝硬化患者体内维生素D缺乏程度与肝硬化的严重程度、并发症的发生关系密切。介绍了维生素D及其受体在肝硬化病情评估及治疗中的作用,指出维生素D不仅有助于评估肝硬化病情的严重程度,也有可能作为肝硬化治疗的新切入点并成为重要的辅助药物。
Bibliography:	liver cirrhosis; vitamin D; receptor; calcitriol; review Vitamin D is mainly produced in the liver,and chronic liver injury caused by various reasons will affect the metabolism of vitamin D,lead to vitamin D deficiency,and accelerate disease progression. Recent studies have confirmed that in patients with liver cirrhosis,the degree of vitamin D deficiency is closely associated with the severity and complications of liver cirrhosis. This article introduces the role of vitamin D and vitamin D receptor in the evaluation and treatment of liver cirrhosis and points out that vitamin D helps to evaluate the severity of liver cirrhosis and may become a new point and an important drug for the treatment of liver cirrhosis. ZHU Binghua, XU Lierrdng. （ Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China） 22-1108/R
ISSN:	1001-5256
DOI:	10.3969/j.issn.1001-5256.2016.08.044