Red cell distribution width (RDW) as a biomarker for respiratory failure in a pediatric ICU

• Published in: Journal of inflammation (London, England) Vol. 14; no. 1; pp. 12 - 7
• Main Authors: Schepens, Tom, De Dooy, Jozef J., Verbrugghe, Walter, Jorens, Philippe G.
• Format: Journal Article
• Language: English
• Published: London BioMed Central 07.06.2017; BioMed Central Ltd; BMC
• Subjects: Allergology; Analysis; Anemia; Biomedical and Life Sciences; Biomedicine; Blood cell count; Cardiovascular disease; Children; Chronic obstructive pulmonary disease; Clinical trials; Congenital diseases; Critical care; Cytokines and Growth Factors; Gastroenterology; Health aspects; Immunology; Intensive care units; Mechanical ventilation; Mortality; Outcomes; Pharmacology/Toxicology; Respiratory failure; Respiratory function; Reticulocytes; Rheumatology; Ventilators; Clinical trials; Critical care; Mechanical ventilation; Outcomes
• ISSN: 1476-9255; 1476-9255
• DOI: 10.1186/s12950-017-0160-9

Background The red cell distribution width (RDW) is a widely available, inexpensive, and highly reproducible test that reflects the range of the red cell sizes. Any process that releases reticulocytes in the circulation will result in an increase in RDW. Elevated RDW values are linked to worsened pulmonary function in the adult population. We performed a retrospective cohort study to describe the association between RDW and respiratory failure in critically ill children in a in a pediatric intensive care unit (PICU) in a tertiary university hospital. Subjects All patients admitted between January 2009 and June 2015 were considered eligible for inclusion. Methods Retrospective cohort study. Results In total, 960 patients were included in the cohort analysis. Of those patients, 149 (15.5%) had elevated RDW values. RDW on admission was associated with lower 28 day ventilator-free days. The highest quintile of RDW was associated with the need for mechanical ventilation, even when correcting for anaemia, age and Pediatric Risk of Mortality (PRISM) scores. In the subgroup of ventilated patients, RDW was associated with nadir PaO 2 /FiO 2 (P/F) ratios. Conclusion The RDW value on admission of our PICU patients is associated with a greater need for invasive mechanical ventilation, lower 28 day ventilator-free days and lower nadir P/F ratios in the patients with highest RDW values on admission. RDW may be a valuable, cheap and universally available, prognostic parameter for respiratory dysfunction in the PICU.