Common variants at five new loci associated with early-onset inflammatory bowel disease

• Published in: Nature genetics Vol. 41; no. 12; pp. 1335 - 1340
• Main Authors: Imielinski, Marcin, Baldassano, Robert N, Griffiths, Anne, Russell, Richard K, Annese, Vito, Dubinsky, Marla, Kugathasan, Subra, Bradfield, Jonathan P, Walters, Thomas D, Sleiman, Patrick, Kim, Cecilia E, Muise, Aleixo, Wang, Kai, Glessner, Joseph T, Saeed, Shehzad, Zhang, Haitao, Frackelton, Edward C, Hou, Cuiping, Flory, James H, Otieno, George, Chiavacci, Rosetta M, Grundmeier, Robert, Castro, Massimo, Latiano, Anna, Dallapiccola, Bruno, Stempak, Joanne, Abrams, Debra J, Taylor, Kent, McGovern, Dermot, Heyman, Melvin B, Ferry, George D, Kirschner, Barbara, Lee, Jessica, Essers, Jonah, Grand, Richard, Stephens, Michael, Levine, Arie, Piccoli, David, Van Limbergen, Johan, Cucchiara, Salvatore, Monos, Dimitri S, Guthery, Stephen L, Denson, Lee, Wilson, David C, Grant, Struan F A, Daly, Mark, Silverberg, Mark S, Satsangi, Jack, Hakonarson, Hakon
• Format: Journal Article Web Resource
• Language: English
• Published: New York Nature Publishing Group US 01.12.2009; Nature Publishing Group
• Subjects: Age of Onset; Agriculture; Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; Bowel disease; Cancer Research; Chromosome Mapping; Colitis, Ulcerative - genetics; Gastroenterology & hepatology; Gastroentérologie & hépatologie; Gene Function; Genetic aspects; Genetic Variation; Genome, Human; Genome-Wide Association Study; Hospitals; Human Genetics; Human health sciences; Humans; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - epidemiology; Inflammatory Bowel Diseases - genetics; letter; Medical research; Meta-analysis; Nutrition research; Quantitative trait loci; Risk factors; Sciences de la santé humaine; Studies; Young adults; United States
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.489

Hakon Hakonarson and colleagues report the discovery of five new regions associated with susceptibility to early-onset inflammatory bowel disease. They also identify multiple loci previously implicated in the etiology of adult-onset Crohn's disease and/or ulcerative colitis as risk factors for early-onset forms of these diseases. The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD 1 . We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 × 10 −9 ), 22q12 (rs2412973, P = 1.55 × 10 −9 ), 10q22 (rs1250550, P = 5.63 × 10 −9 ), 2q37 (rs4676410, P = 3.64 × 10 −8 ) and 19q13.11 (rs10500264, P = 4.26 × 10 −10 ). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.