吉兰-巴雷综合征患者外周血Th17细胞和IL-23表达变化与其发病机制的相关性研究

探讨吉兰-巴雷综合征患者外周血Th17细胞、血清和脑脊液IL-23表达变化在其免疫发病机制中的作用。流式细胞术和酶联免疫吸附试验显示，吉兰-巴雷综合征组患者外周血Th17细胞比例[（4．86±0．60）％]和血清IL-23水平[（111．80±13．84）pg／ml]均高于对照组[（2．71±0．54）％、（72．55±8．19）pg／m1]，差异有统计学意义（t=2．616，P=0．012；t=2．300，P=0．026）。吉兰．巴雷综合征组患者经静脉注射免疫球蛋白后，血清和脑脊液IL-23水平恢复正常[（74．13±6．18）和（72．92±12．09）pg／m1]，与治疗前[（110．5...

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Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 14; no. 6; pp. 526 - 530
Main Author 何改平
Format Journal Article
LanguageChinese
Published 300222,天津市第四医院脑系科 2014
Subjects
T淋巴细胞，辅助诱导
多发性神经根神经病
白细胞介素23
T-lymphocytes
白细胞介素23
Polyradiculoneuropathy
helper-inducer
Interleukin-23
T淋巴细胞,辅助诱导
多发性神经根神经病
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ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2014.06.012

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Summary:探讨吉兰-巴雷综合征患者外周血Th17细胞、血清和脑脊液IL-23表达变化在其免疫发病机制中的作用。流式细胞术和酶联免疫吸附试验显示，吉兰-巴雷综合征组患者外周血Th17细胞比例[（4．86±0．60）％]和血清IL-23水平[（111．80±13．84）pg／ml]均高于对照组[（2．71±0．54）％、（72．55±8．19）pg／m1]，差异有统计学意义（t=2．616，P=0．012；t=2．300，P=0．026）。吉兰．巴雷综合征组患者经静脉注射免疫球蛋白后，血清和脑脊液IL-23水平恢复正常[（74．13±6．18）和（72．92±12．09）pg／m1]，与治疗前[（110．50±15．66）和（102．30±7．52）pg／m1]相比，差异具有统计学意义（t=2．557，P=0．022；t=1．422，P=0．046）。吉兰-巴雷综合征患者外周血Th17细胞比例增加、血清和脑脊液IL-23水平升高，提示二者可能参与吉兰．巴雷综合征的发生与发展。
Bibliography:HE Gai-ping, ZHANG Bin, ZHANG Bao-wen, QIAO Liang-jie （Department of Neurology, Tianjin Fourth Hospital, Tianjin 300222, China）
Guillain- Barr6 syndrome （GBS） is an acute autoimmune- mediated inflammatory neuropathy. In this paper, the percentage of Thl7 in peripheral blood lymphocyte and the level of IL-23 in serum and cerebrospinal fluid （CSF） of patients with GBS were detected. Twenty-five patients with GBS and 20 controls were analyzed. The percentage of Thl7 cells in patients with GBS was （4.86 ± 0.60）%, which was higher than that in controls [（2.71 ± 0.54）%; t = 2.616, P = 0.012]. Serum IL-23 increased in patients with GBS [（111.80 ± 13.84）pg/ml vs （72.55±8.19） pg/ml; t = 2.300, P = 0.026]. The level of IL-23 in serum and CSF from patients with GBS before therapy [（110.50± 15.66i and （102.30 ±7.52） pg/ml] declined to normal after therapy [（74.13 ±6.18） and （72.92 ± 12.09） pg/ml], and the difference was statistically significant （t = 2.557, P = 0.022; t = 1.422, P = 0.046）. Th17 cells and IL-23 increased
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2014.06.012