抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体分流术预后的影响
目的探讨抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体静脉分流术（TIPS）预后的影响。方法回顾性分析2008年1月-2011年12月行TIPS预防静脉曲张破裂再出血的失代偿期乙型肝炎肝硬化患者110例,按其是否使用抗病毒药物,分为TIPS联合抗病毒组（58例）与TIPS组（52例）,计量资料组间比较采用t检验或Wilcoxon秩和检验,计数资料组间比较采用χ2检验,累积生存率、再出血率、支架通畅率和肝细胞癌发生率采用Kaplan-Meier生存分析及log-rank检验。结果 TIPS联合抗病毒组和TIPS组患者TIPS术后1、3和5年累积生存率分别为93.1%、86.1%、77.7...
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| Published in | 临床肝胆病杂志 Vol. 32; no. 2; pp. 254 - 258 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
四川大学华西医院消化内科,成都,610041
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2016.02.011 |
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| Abstract | 目的探讨抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体静脉分流术（TIPS）预后的影响。方法回顾性分析2008年1月-2011年12月行TIPS预防静脉曲张破裂再出血的失代偿期乙型肝炎肝硬化患者110例,按其是否使用抗病毒药物,分为TIPS联合抗病毒组（58例）与TIPS组（52例）,计量资料组间比较采用t检验或Wilcoxon秩和检验,计数资料组间比较采用χ2检验,累积生存率、再出血率、支架通畅率和肝细胞癌发生率采用Kaplan-Meier生存分析及log-rank检验。结果 TIPS联合抗病毒组和TIPS组患者TIPS术后1、3和5年累积生存率分别为93.1%、86.1%、77.7%和88.5%、64.9%、59.7%,TIPS联合抗病毒组的累积生存率显著优于TIPS组（χ2=6.833,P=0.009）。TIPS联合抗病毒组的病毒学应答率随着抗病毒治疗时间的延长而逐渐升高。两组累积静脉曲张再出血率、支架通畅率、肝细胞癌发生率的差异均无统计学意义（P值均〉0.05）。结论抗病毒治疗可改善失代偿期乙型肝炎肝硬化TIPS术后患者的生存率。 |
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| AbstractList | R575.2; 目的 探讨抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体静脉分流术(TIPS)预后的影响.方法 回顾性分析2008年1月-2011年12月行TIPS预防静脉曲张破裂再出血的失代偿期乙型肝炎肝硬化患者110例,按其是否使用抗病毒药物,分为TIPS联合抗病毒组(58例)与TIPS组(52例),计量资料组间比较采用t检验或Wilcoxon秩和检验,计数资料组间比较采用x2检验,累积生存率、再出血率、支架通畅率和肝细胞癌发生率采用Kaplan-Meier生存分析及log-rank检验.结果 TIPS联合抗病毒组和TIPS组患者TIPS术后1、3和5年累积生存率分别为93.1％、86.1％ 、77.7％和88.5％、64.9％、59.7％,TIPS联合抗病毒组的累积生存率显著优于TIPS组(x2=6.833,P=0.009).TIPS联合抗病毒组的病毒学应答率随着抗病毒治疗时间的延长而逐渐升高.两组累积静脉曲张再出血率、支架通畅率、肝细胞癌发生率的差异均无统计学意义(P值均＞0.05).结论 抗病毒治疗可改善失代偿期乙型肝炎肝硬化TIPS术后患者的生存率. 目的探讨抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体静脉分流术（TIPS）预后的影响。方法回顾性分析2008年1月-2011年12月行TIPS预防静脉曲张破裂再出血的失代偿期乙型肝炎肝硬化患者110例,按其是否使用抗病毒药物,分为TIPS联合抗病毒组（58例）与TIPS组（52例）,计量资料组间比较采用t检验或Wilcoxon秩和检验,计数资料组间比较采用χ2检验,累积生存率、再出血率、支架通畅率和肝细胞癌发生率采用Kaplan-Meier生存分析及log-rank检验。结果 TIPS联合抗病毒组和TIPS组患者TIPS术后1、3和5年累积生存率分别为93.1%、86.1%、77.7%和88.5%、64.9%、59.7%,TIPS联合抗病毒组的累积生存率显著优于TIPS组（χ2=6.833,P=0.009）。TIPS联合抗病毒组的病毒学应答率随着抗病毒治疗时间的延长而逐渐升高。两组累积静脉曲张再出血率、支架通畅率、肝细胞癌发生率的差异均无统计学意义（P值均〉0.05）。结论抗病毒治疗可改善失代偿期乙型肝炎肝硬化TIPS术后患者的生存率。 |
| Author | 林静 魏波 吴浩 童欢 唐承薇 |
| AuthorAffiliation | 四川大学华西医院消化内科,成都610041 |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DocumentTitleAlternate | Effect of antiviral therapy on prognosis of patients with decompensated hepatitis B cirrhosis undergoing transjugular intrahepatic portosystemic shunt |
| DocumentTitle_FL | Effect of antiviral therapy on prognosis of patients with decompensated hepatitis B cirrhosis undergoing transjugular intrahepatic portosystemic shunt |
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| Keywords | 抗病毒药 portosystemic shunt,transjugular intrahepatic 肝炎,乙型 hepatitis B antiviral agents 肝硬化 预后 门体分流术,经颈静脉肝内 prognosis liver cirrhosis |
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| Notes | liver cirrhosis ; hepatitis B ; antiviral agents ; portosystemic shunt, transjugular intrahepatic ; prognosis LIN Jing, WEI Bo, WU Hao, et al. （Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China） Objective To investigate the effect of antiviral therapy on the prognosis of patients with decompensated hepatitis B cirrhosis who underwent transjugular intrahepatic portosystemic shunt （TIPS）. Methods The clinical data of 110 patients with decompensated hepatitis B cirrhosis who underwent TIPS to prevent variceal rebleeding from January 2008 to December 2011 were analyzed retrospectively, and based on whether they used antiviral drugs or not, these patients were divided into TIPS -antiviral drug group （58 patients） and TIPS group （52 patients）. The t - test or Wilcoxon rank sum test was applied for comparison of continuous data between the two groups, and the chi - square test was applied for comparison of categorical data between the two groups. The Kaplan - Meier survival |
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| PublicationTitle | 临床肝胆病杂志 |
| PublicationTitleAlternate | Chinese Journal of Clinical Hepatology |
| PublicationTitle_FL | Journal of Clinical Hepatology |
| PublicationYear | 2016 |
| Publisher | 四川大学华西医院消化内科,成都,610041 |
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| SubjectTerms | 抗病毒药 肝炎,乙型 肝硬化 门体分流术,经颈静脉肝内 预后 |
| Title | 抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体分流术预后的影响 |
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