抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体分流术预后的影响

目的探讨抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体静脉分流术（TIPS）预后的影响。方法回顾性分析2008年1月-2011年12月行TIPS预防静脉曲张破裂再出血的失代偿期乙型肝炎肝硬化患者110例,按其是否使用抗病毒药物,分为TIPS联合抗病毒组（58例）与TIPS组（52例）,计量资料组间比较采用t检验或Wilcoxon秩和检验,计数资料组间比较采用χ2检验,累积生存率、再出血率、支架通畅率和肝细胞癌发生率采用Kaplan-Meier生存分析及log-rank检验。结果 TIPS联合抗病毒组和TIPS组患者TIPS术后1、3和5年累积生存率分别为93.1%、86.1%、77.7...

Full description

Saved in:
Bibliographic Details
Published in临床肝胆病杂志 Vol. 32; no. 2; pp. 254 - 258
Main Author 林静 魏波 吴浩 童欢 唐承薇
Format Journal Article
LanguageChinese
Published 四川大学华西医院消化内科,成都,610041 2016
Subjects
抗病毒药
肝炎,乙型
肝硬化
门体分流术,经颈静脉肝内
预后
抗病毒药
portosystemic shunt,transjugular intrahepatic
肝炎,乙型
hepatitis B
antiviral agents
肝硬化
预后
门体分流术,经颈静脉肝内
prognosis
liver cirrhosis
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2016.02.011

Cover

More Information
Summary:目的探讨抗病毒治疗对失代偿期乙型肝炎肝硬化患者经颈静脉肝内门体静脉分流术（TIPS）预后的影响。方法回顾性分析2008年1月-2011年12月行TIPS预防静脉曲张破裂再出血的失代偿期乙型肝炎肝硬化患者110例,按其是否使用抗病毒药物,分为TIPS联合抗病毒组（58例）与TIPS组（52例）,计量资料组间比较采用t检验或Wilcoxon秩和检验,计数资料组间比较采用χ2检验,累积生存率、再出血率、支架通畅率和肝细胞癌发生率采用Kaplan-Meier生存分析及log-rank检验。结果 TIPS联合抗病毒组和TIPS组患者TIPS术后1、3和5年累积生存率分别为93.1%、86.1%、77.7%和88.5%、64.9%、59.7%,TIPS联合抗病毒组的累积生存率显著优于TIPS组（χ2=6.833,P=0.009）。TIPS联合抗病毒组的病毒学应答率随着抗病毒治疗时间的延长而逐渐升高。两组累积静脉曲张再出血率、支架通畅率、肝细胞癌发生率的差异均无统计学意义（P值均〉0.05）。结论抗病毒治疗可改善失代偿期乙型肝炎肝硬化TIPS术后患者的生存率。
Bibliography:liver cirrhosis ; hepatitis B ; antiviral agents ; portosystemic shunt, transjugular intrahepatic ; prognosis
LIN Jing, WEI Bo, WU Hao, et al. （Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China）
Objective To investigate the effect of antiviral therapy on the prognosis of patients with decompensated hepatitis B cirrhosis who underwent transjugular intrahepatic portosystemic shunt （TIPS）. Methods The clinical data of 110 patients with decompensated hepatitis B cirrhosis who underwent TIPS to prevent variceal rebleeding from January 2008 to December 2011 were analyzed retrospectively, and based on whether they used antiviral drugs or not, these patients were divided into TIPS -antiviral drug group （58 patients） and TIPS group （52 patients）. The t - test or Wilcoxon rank sum test was applied for comparison of continuous data between the two groups, and the chi - square test was applied for comparison of categorical data between the two groups. The Kaplan - Meier survival
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2016.02.011