多拉菌素浇泼剂临床前毒理学研究

观察多拉菌素浇泼剂对小鼠骨髓嗜多染红细胞微核率及小鼠精子畸形率的影响，结果显示，用于小鼠最高剂量30mg ·kg^-1BW时，无致畸性，无遗传毒性作用。结果表明多拉菌素浇泼剂是一种新型治疗动物寄生虫病较为安全的局部外用药物，适合在兽医临床上推广应用。...

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Bibliographic Details
Published in	东北农业大学学报 Vol. 44; no. 12; pp. 108 - 112
Main Author	高玉红石艳丽李晓云宋铭忻
Format	Journal Article
Language	Chinese
Published	东北农业大学动物医学学院,哈尔滨150030 2013 黑龙江职业学院,哈尔滨150080%东北农业大学动物医学学院,哈尔滨,150030
Subjects	多拉菌素浇泼剂精子畸形率骨髓微核精子畸形率 doramectin 多拉菌素浇泼剂骨髓微核 sperm deformity rate bone marrow micronucleus pour-on preparation
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ISSN	1005-9369

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Summary:	观察多拉菌素浇泼剂对小鼠骨髓嗜多染红细胞微核率及小鼠精子畸形率的影响，结果显示，用于小鼠最高剂量30mg ·kg^-1BW时，无致畸性，无遗传毒性作用。结果表明多拉菌素浇泼剂是一种新型治疗动物寄生虫病较为安全的局部外用药物，适合在兽医临床上推广应用。
Bibliography:	23-1391/S GAO Yuhong, SHI Yanli, LI Xiaoyun, SONG Mingxin （1. School of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; 2. Heilongjiang Vocational College, Harbin 150080, China） doramectin; pour-on preparation; bone marrow micronucleus; sperm deformity rate To study doramectin pour-on preparation on mouse bone marrow micronucleus rate and mouse sperm deformity rate. The experimental results showed that for the highest dose in mice 30 mg· kg^-1 BW, no teratogenicity, and no genetic toxic effects. Doramectin pour-on preparation was a relatively safe local foreign agents for clinical application.
ISSN:	1005-9369