过氧化物酶体增殖物激活受体γ基因rs3856806位点多态性与非酒精性脂肪性肝病的相关性分析

目的探讨过氧化物酶体增殖物激活受体（PPAR）γ基因rs3856806位点多态性与非酒精性脂肪性肝病（NAFLD）的相关性。方法随机收集2013年5月-2014年5月收治的189例经B超证实为NAFLD患者和184例对照组健康者的血液标本,应用多重高温连接酶检测反应技术（i MLDR）检测PPARγ基因rs3856806位点基因型。计数资料及计量资料分别采用Pearsonχ2检验和t检验进行比较,Logistic回归分析用于计算比值比（OR）及其95%可信区间（95%CI）。结果 NAFLD组体质量、腰围、臀围、ALT、AST、GGT、空腹血糖（FPG）、总胆固醇（TC）、甘油三酯（TG）及低...

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Published in	临床肝胆病杂志 Vol. 31; no. 7; pp. 1088 - 1091
Main Author	许新姜曼李江文董全勇林中华初蕾蕾辛永宁宣世英
Format	Journal Article
Language	Chinese
Published	青岛市市立医院消化内二科,山东青岛266021%青岛市消化疾病重点实验室,山东青岛,266021%青岛市市立医院消化内二科,山东青岛,266021%青岛市市立医院消化内二科,山东青岛266021 2015 青岛市消化疾病重点实验室,山东青岛266021%青岛市市立医院消化内二科,山东青岛266021 青岛市消化疾病重点实验室,山东青岛266021 中国海洋大学医药学院,山东青岛266003 大连医科大学,辽宁大连116044
Subjects	多态性,单核苷酸脂肪肝过氧化物酶体增殖物激活受体过氧化物酶体增殖物激活受体脂肪肝 fatty liver polymorphism,single nucleotide 多态性,单核苷酸 peroxisome proliferator-activated receptors
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ISSN	1001-5256
DOI	10.3969/j.issn.1001-5256.2015.07.021

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Summary:	目的探讨过氧化物酶体增殖物激活受体（PPAR）γ基因rs3856806位点多态性与非酒精性脂肪性肝病（NAFLD）的相关性。方法随机收集2013年5月-2014年5月收治的189例经B超证实为NAFLD患者和184例对照组健康者的血液标本,应用多重高温连接酶检测反应技术（i MLDR）检测PPARγ基因rs3856806位点基因型。计数资料及计量资料分别采用Pearsonχ2检验和t检验进行比较,Logistic回归分析用于计算比值比（OR）及其95%可信区间（95%CI）。结果 NAFLD组体质量、腰围、臀围、ALT、AST、GGT、空腹血糖（FPG）、总胆固醇（TC）、甘油三酯（TG）及低密度脂蛋白（LDL）均高于正常对照组,差异均有统计学意义（P值均〈0.05）;高密度脂蛋白（HDL）低于对照组,差异亦有统计学意义（P值均〈0.01）。NAFLD组与对照组两者rs3856806位点的等位基因及基因型分布频率差异无统计学意义（P值均〉0.05）;等位基因T携带者患NAFLD的风险是等位基因C的1.068倍（OR=1.068,95%CI：0.748~1.525,P〉0.05）。非条件Logistic回归分析结果表明,与CC携带者相比,TT的基因型携带者的NAFLD发生风险高（OR=1.077,95%CI：0.706~1.643,P〉0.05）。结论 PPARγ基因rs3856806位点多态性与NAFLD的发生无明显相关性。
Bibliography:	Objective To investigate the association between PPARγ gene rs3856806 polymorphism and nonalcoholic fatty liver disease（ NAFLD）. Methods The blood samples of 189 patients who were diagnosed with NAFLD by B- ultrasound and 184 healthy normal subjects were collected to determine the genotypes of PPARγ gene rs3856806 by improved multiple ligase detection reaction. Comparison of categorical data between the two groups was made by Pearson chi- square test,and comparison of continuous data was made by t test. And the logistic regression analysis was used for calculating odds ratio（ OR） and 95% confidence interval（ 95% CI）. Results The NAFLD group had significantly higher body weight,waist circumference,hip circumference,and levels of alanine aminotransferase,aspartate aminotransferase,gamma- glutamyl transpeptidase,glucose,triglyceride,total cholesterol,and low- density lipoprotein than the control group（ P 〈0. 05）. However,the NAFLD group had a significantly lower level of high- density lipoprotein than the contro
ISSN:	1001-5256
DOI:	10.3969/j.issn.1001-5256.2015.07.021