Effects of adipose tissue distribution on maximum lipid oxidation rate during exercise in normal-weight women

• Published in: Diabetes & metabolism Vol. 40; no. 3; pp. 215 - 219
• Main Authors: Isacco, L., Thivel, D., Duclos, M., Aucouturier, J., Boisseau, N.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier Masson SAS 01.06.2014; Masson; Elsevier Masson
• Subjects: Abdominal Fat - metabolism; Absorptiometry, Photon; Adipose Tissue - metabolism; Adipose tissue localization; Adult; Agricultural sciences; Biological and medical sciences; Body Composition; Body Fat Distribution; Body Mass Index; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinology & Metabolism; Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Exercise; Exercise Test; Female; France; Humans; Internal Medicine; Life Sciences; Lipid Metabolism; Lipoxmax; Medical sciences; Metabolic fitness; Oxidation-Reduction; Women; France; Women; FFA; Metabolic fitness; ANP; MLOR; FM; NW; Adipose tissue localization; CHO; DXA; FFM; L-A/LB; SD; Lipoxmax; Exercise; VCO2; VO2; VO2max; A/LB; H-A/LB; MAP; BMI; fat mass; abdominal to lower-body; fat-free mass; free fatty acids; carbohydrate; VCO 2; oxygen consumption; Lipox max; atrial natriuretic peptide; maximum oxygen consumption; VO 2; maximum aerobic power; body mass index; low abdominal to lower-body; maximum lipid oxidation rate; carbon dioxide production; normal-weight; VO 2max; dual X-ray absorptiometry; high abdominal to lower-body; standard deviation; Endocrinopathy; Physical exercise; Human; Adipose tissue; Diabetes mellitus; Lipids; Physical fitness; Distribution; Female; Oxidation; Localization; Lipox; Lipox(max)
• ISSN: 1262-3636; 1878-1780; 1878-1780
• DOI: 10.1016/j.diabet.2014.02.006

Fat mass localization affects lipid metabolism differently at rest and during exercise in overweight and normal-weight subjects. The aim of this study was to investigate the impact of a low vs high ratio of abdominal to lower-body fat mass (index of adipose tissue distribution) on the exercise intensity (Lipoxmax) that elicits the maximum lipid oxidation rate in normal-weight women. Twenty-one normal-weight women (22.0±0.6 years, 22.3±0.1kg.m−2) were separated into two groups of either a low or high abdominal to lower-body fat mass ratio [L-A/LB (n=11) or H-A/LB (n=10), respectively]. Lipoxmax and maximum lipid oxidation rate (MLOR) were determined during a submaximum incremental exercise test. Abdominal and lower-body fat mass were determined from DXA scans. The two groups did not differ in aerobic fitness, total fat mass, or total and localized fat-free mass. Lipoxmax and MLOR were significantly lower in H-A/LB vs L-A/LB women (43±3% VO2maxvs 54±4% VO2max, and 4.8±0.6mgmin−1kg FFM−1vs 8.4±0.9mgmin−1kg FFM−1, respectively; P<0.001). Total and abdominal fat mass measurements were negatively associated with Lipoxmax (r=–0.57 and r=–0.64, respectively; P<0.01) and MLOR [r=–0.63 (P<0.01) and r=–0.76 (P<0.001), respectively]. These findings indicate that, in normal-weight women, a predominantly abdominal fat mass distribution compared with a predominantly peripheral fat mass distribution is associated with a lower capacity to maximize lipid oxidation during exercise, as evidenced by their lower Lipoxmax and MLOR.