肝X受体在胆固醇代谢过程中的作用机制

胆固醇是细胞膜的组成成分,对维持机体代谢及正常的功能有着至关重要的作用。肝X受体（LXR）是肝脏中丰富表达的一种核受体,通过在肝细胞层面调控胆固醇及胆汁酸的合成、转化及转运来影响胆固醇代谢过程,在维持机体胆固醇稳态中发挥重要作用。另外,LXR能抑制食物中胆固醇在肠道的吸收,从而降低机体外源性胆固醇水平,从一定程度上降低机体总胆固醇水平,预防高胆固醇血症、胆结石等的形成。从肝脏和肠道两个层面对LXR调控胆固醇代谢的机制进行了总结。...

Full description

Saved in:
Bibliographic Details
Published in临床肝胆病杂志 Vol. 32; no. 5; pp. 1013 - 1017
Main Author 陈裕 范晓飞 郑忠清 王邦茂
Format Journal Article
LanguageChinese
Published 天津医科大学总医院消化科,天津市消化病学研究所,天津300052 2016
Subjects
综述
肝X受体
胆固醇
胆酸类
肝X受体
cholic acids
review
cholesterol
综述
胆酸类
liver X receptor
胆固醇
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2016.05.049

Cover

More Information
Summary:胆固醇是细胞膜的组成成分,对维持机体代谢及正常的功能有着至关重要的作用。肝X受体（LXR）是肝脏中丰富表达的一种核受体,通过在肝细胞层面调控胆固醇及胆汁酸的合成、转化及转运来影响胆固醇代谢过程,在维持机体胆固醇稳态中发挥重要作用。另外,LXR能抑制食物中胆固醇在肠道的吸收,从而降低机体外源性胆固醇水平,从一定程度上降低机体总胆固醇水平,预防高胆固醇血症、胆结石等的形成。从肝脏和肠道两个层面对LXR调控胆固醇代谢的机制进行了总结。
Bibliography:cholesterol; liver X receptor; cholic acids; review
CHEN Yu, FAN Xiaofei, ZHENG Zhongqing, et al. （ Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China）
Cholesterol is a component of cell membrane and plays a vital role in maintaining metabolism and normal functions in human body. Liver X receptor（ LXR） is a nuclear receptor expressed in abundance in the liver. It influences the process of cholesterol metabolism through regulating the synthesis,transformation,and transportation of cholesterol and bile acid at the level of hepatocytes,and therefore,it plays an important role in maintaining cholesterol homeostasis in human body. In addition,LXR can inhibit the intestinal absorption of dietary cholesterol,reduce exogenous cholesterol level and total cholesterol level in human body,and prevent hypercholesterolemia and formation of gallstones. This article summarizes the mechanism of action of LXR in regulating cholesterol metabolism at both liver and intestinal levels.
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2016.05.049