慢性肝病患者血清25-羟维生素D水平及临床意义

目的:探讨慢性肝病患者血清25-羟维生素 D[25(OH)D]水平及其临床意义。方法收集2012年6月-2013年9月吉林大学第一医院肝胆胰内科153例慢性肝病住院患者的血清作为试验组,应用液相色谱串联质谱检测技术检测患者的25(OH)D水平,以同院体检中心300例健康人作对照组。试验组分为非肝硬化组、肝硬化组(Child -Pugh A、B、C 级)及原发性胆汁性肝硬化(PBC)组,分析比较各组间的差异,计量资料采用 t 检验和方差分析,计数资料采用χ2检验,各变量间相关性采用 Pearson 直线相关分析。结果153例慢性肝病患者正常(≥30 ng/ml)、不足(20~30 ng/ml)、...

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Published in临床肝胆病杂志 Vol. 31; no. 5; pp. 754 - 757
Main Author 杨伟民 辛桂杰 丁胜楠
Format Journal Article
LanguageChinese
Published 吉林大学第一医院 肝胆胰内科,长春,130021 2015
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2015.05.029

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Summary:目的:探讨慢性肝病患者血清25-羟维生素 D[25(OH)D]水平及其临床意义。方法收集2012年6月-2013年9月吉林大学第一医院肝胆胰内科153例慢性肝病住院患者的血清作为试验组,应用液相色谱串联质谱检测技术检测患者的25(OH)D水平,以同院体检中心300例健康人作对照组。试验组分为非肝硬化组、肝硬化组(Child -Pugh A、B、C 级)及原发性胆汁性肝硬化(PBC)组,分析比较各组间的差异,计量资料采用 t 检验和方差分析,计数资料采用χ2检验,各变量间相关性采用 Pearson 直线相关分析。结果153例慢性肝病患者正常(≥30 ng/ml)、不足(20~30 ng/ml)、缺乏(10~20 ng/ml)及严重缺乏(<10 ng/ml)的比例分别为20.3%、22.9%、35.9%、20.9%。肝硬化组25(OH)D 缺乏及严重缺乏的比例(41.7%、25.0%)明显多于非肝硬化组(27.5%、12.5%)及 PBC 组(23.5%、17.6%),差异均有统计学意义(χ2=6.261~18.474,P =0.001~0.012)。肝硬化组25(OH)D 水平为(18.58±12.48)ng/ml,低于非肝硬化组(23.78±11.81)ng/ml 及健康对照组(25.69±12.39)ng/ml,差异均有统计学意义(P值分别为0.029、0.001)。肝硬化组以 Child -Pugh 分级分组,C 级25(OH)D 水平明显低于 A 级,差异有统计学意义(P =0.009)。结论慢性肝病患者血清25(OH)D 水平普遍降低,其中肝硬化患者降低明显重于非肝硬化患者,尤其以 Child -Pugh 分级 C 级降低最为严重。
Bibliography:liver diseases; vitamin D deficiency
YANG Weimin, XIN Guijie, DING Shengnan(Department of Hepatobiliary and Pancreatic Diseases, The First Hospital of Jilin University, Changchun 130021, China)
Objective To investigate the levels and clinical significance of serum 25 -hydroxy vitamin D[25 (OH)D]in patients with chronic liver disease.Methods A total of 153 hospitalized patients with chronic liver disease in the First Affiliated Hospital of Jilin Univer-sity from June 2012 to September 2013 were enrolled in the study group.The levels of serum 25(OH)D were measured by liquid chromatog-raphy tandem mass spectrometry.The serum samples from 300 healthy volunteers who underwent physical examination in our hospital were used as controls.The study group was divided into three subgroups:non -cirrhosis,liver cirrhosis [Child -Pugh (CP)grades A,B,and C],and primary biliary cirrhosis.Comparison of continuous data between groups was made by t test and analysis of variance,and compari-son of categorical data was made by chi -
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2015.05.029