肺癌组织环指蛋白RNF38的表达及其临床意义

目的：探讨肺癌组织环指蛋白RNF38的表达及其与肺癌临床病理特征及预后的关系.方法：采用组织芯片检测208例肺癌组织中RNF38蛋白表达,分析其与肺癌患者临床病理特征及预后的关系.结果：肺癌组织RNF38表达高于癌旁正常肺组织.不同肿瘤大小（P=0.0002）、不同肿瘤分期（P=0.011）、有无淋巴结转移（P=0.00004）及不同肿瘤类型（P=0.030）患者肺癌组织RNF38蛋白表达差异有统计学意义.RNF38高表达预示肺癌患者总生存率低.单因素分析显示RNF38表达与肺癌患者预后相关.结论：RNF38高表达与肺癌的恶性表型及不良预后相关....

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Published in中国临床医学 Vol. 24; no. 1; pp. 86 - 88
Main Author 李继军 金淳 熊点 蒋家好 丁建勇
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院胸外科,上海 200032 2017
新疆维吾尔自治区喀什第二人民医院心胸外科,喀什 844000%复旦大学附属中山医院胸外科,上海,200032%南昌大学第二附属医院心胸外科,南昌,330006
Subjects
RNF38
肺癌
预后
lung cancer
预后
肺癌
prognosis
RNF38
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ISSN1008-6358
DOI10.12025/j.issn.1008-6358.2017.20170053

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Summary:目的：探讨肺癌组织环指蛋白RNF38的表达及其与肺癌临床病理特征及预后的关系.方法：采用组织芯片检测208例肺癌组织中RNF38蛋白表达,分析其与肺癌患者临床病理特征及预后的关系.结果：肺癌组织RNF38表达高于癌旁正常肺组织.不同肿瘤大小（P=0.0002）、不同肿瘤分期（P=0.011）、有无淋巴结转移（P=0.00004）及不同肿瘤类型（P=0.030）患者肺癌组织RNF38蛋白表达差异有统计学意义.RNF38高表达预示肺癌患者总生存率低.单因素分析显示RNF38表达与肺癌患者预后相关.结论：RNF38高表达与肺癌的恶性表型及不良预后相关.
Bibliography:31-1794/R
LI Ji-jun1,2,JIN Chun1,XIONG Dian3,JIANG Jia-hao1,DING Jian-yong1（1. Department of Chest Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2. Department of Cardiothoracic Surgery,Second People＇ s Hospital of Kashgar, Kashgar 844000,the Xinjiang Uygur Autonomous Region, China;3. Department of Cardiothoracic Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China）
RNF38;lung cancer;prognosis
Objective：To investigate the expression of RNF38 in lung cancer,and its correlationship with clinicopathologic feature and prognosis.Methods：Tissue microarray was used to detect the level of RNF38 in 208 lung cancer patients,then its correlationship with clinicopathologic feature and prognosis was analyzed.Results：RNF38 expression was higher in lung cancer tissues compared with the corresponding adjacent normal lung tissues.High level of RNF38 was related significantly to tumor size （P= 0.0002）,tumor stage （P= 0.011）,lymph node metastasis （P= 0.00004）and histolo
ISSN:1008-6358
DOI:10.12025/j.issn.1008-6358.2017.20170053