不同糖皮质激素治疗创伤性视神经病变90例疗效探讨
目的分析创伤性视神经病变(TON)临床药物治疗方法并对比观察治疗效果。方法选取南华大学附属第二医院于2013年1月至2014年12月收治的患者90例(98眼),根据患者治疗用药情况将其分为甲泼尼龙组30例(36眼)、地塞米松组30例(32眼)、对照组(不予激素常规治疗)30例(30眼)。对比观察甲泼尼龙和地塞米松在不同时间段的治疗效果。结果甲泼尼龙组和地塞米松组治疗后总有效率分别为47.22%、34.38%,对照组为13.33%。甲泼尼龙组与地塞米松组比较,差异有统计学意义(P〈0.05),两组分别与对照组比较,差异均有统计学意义(P〈0.01)。甲泼尼龙组与地塞米松组在0-〈8、8-〈24、...
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| Published in | 现代医药卫生 Vol. 32; no. 4; pp. 503 - 505 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
南华大学附属第一医院,湖南衡阳,421001%南华大学附属第二医院,湖南衡阳,421001
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-5519 |
| DOI | 10.3969/j.issn.1009-5519.2016.04.009 |
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| Summary: | 目的分析创伤性视神经病变(TON)临床药物治疗方法并对比观察治疗效果。方法选取南华大学附属第二医院于2013年1月至2014年12月收治的患者90例(98眼),根据患者治疗用药情况将其分为甲泼尼龙组30例(36眼)、地塞米松组30例(32眼)、对照组(不予激素常规治疗)30例(30眼)。对比观察甲泼尼龙和地塞米松在不同时间段的治疗效果。结果甲泼尼龙组和地塞米松组治疗后总有效率分别为47.22%、34.38%,对照组为13.33%。甲泼尼龙组与地塞米松组比较,差异有统计学意义(P〈0.05),两组分别与对照组比较,差异均有统计学意义(P〈0.01)。甲泼尼龙组与地塞米松组在0-〈8、8-〈24、24-〈72 h给药有效率比较,差异均有统计学意义(P〈0.05),而两组72 h后给药有效率比较,差异无统计学意义(P〉0.05)。结论甲泼尼龙与地塞米松均能治疗TON,甲泼尼龙对视神经损伤的治疗作用优于地塞米松。受伤后8 h内只要无禁忌证,应尽早使用糖皮质激素冲击治疗。受伤72 h后给予糖皮质激素疗效较差,是否使用还需权衡利弊。 |
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| Bibliography: | Optic nerve injuries; Methylprednisolone; Dexamethasone; Treatment outcome Huang Qinyuang,Zhou Jun,Xiao Qiguo,Xia Shigang,Xiao Yong(1. First Affiliated Hospital,University of South China,Hengyang,Hunan 421001, China;2. Second Affiliated Hospital, University of South China,Hengyang ,Hunan 421001, China) Objective To analyze the clinical medication methods for treating traumatic optic neuropathy(TON) and to contrastively observe their treatment effects. Methods Totally 90 patients(98 eyes) with TON in the Second Affiliated Hospital of University of South China from January 2013 to December 2014 were selected as the research subjects and divided into the methylprednisolone group(30 cases,36 eyes),dexamethasone group(30 cases,32 eyes) and control group(conventional therapy without using hormone,30 cases,30 eyes). The treatment effects of methylprednisolone and dexamethasone in different time periods were contrastively observed. Results The total effective rate after treatment in the methylprednisolone and dexametha |
| ISSN: | 1009-5519 |
| DOI: | 10.3969/j.issn.1009-5519.2016.04.009 |