高血压患者豆纹动脉数量减少与局部脑代谢物变化的相关性

目的：探讨高血压患者脑微小血管数量减少与局部脑代谢改变的关系。方法：将50例高血压患者和50例健康志愿者纳入本研究。所有研究对象均行三维时间飞跃法磁共振血管成像和磁共振波谱成像扫描,对所有图像进行后处理后计算豆纹动脉数量和基底节区脑代谢物NAA/Cr、Cho/Cr、MI/Cr比值。结果：高血压组和健康志愿者组双侧豆纹动脉数量分别为5.12±0.98、6.10±0.95,差异有统计学意义（P〈0.000 1）。高血压组患者NAA/Cr比值的降低与豆纹动脉数量减少具有一定相关性,单侧豆纹动脉数量≤3时,NAA/Cr比值下降得更显著。结论：高血压患者豆纹动脉数量减少至一定范围可引起基底节区脑代谢物N...

Full description

Saved in:
Bibliographic Details
Published in中国临床医学 Vol. 24; no. 2; pp. 199 - 203
Main Author 潘海宾 李跃华 李晓兵 魏小二 汪璇
Format Journal Article
LanguageChinese
Published 上海市第六人民医院南院奉贤区中心医院放射科,上海,201400%上海市第六人民医院放射科,上海,200233 2017
Subjects
NAA/Cr比值
脑代谢
豆纹动脉
高血压病
brain metabolism
NAA/Cratio
NAA/Cr比值
lenticulostriatarteries
豆纹动脉
hypertension
脑代谢
高血压病
Online AccessGet full text
ISSN1008-6358
DOI10.12025/j.issn.1008-6358.2017.20161132

Cover

More Information
Summary:目的：探讨高血压患者脑微小血管数量减少与局部脑代谢改变的关系。方法：将50例高血压患者和50例健康志愿者纳入本研究。所有研究对象均行三维时间飞跃法磁共振血管成像和磁共振波谱成像扫描,对所有图像进行后处理后计算豆纹动脉数量和基底节区脑代谢物NAA/Cr、Cho/Cr、MI/Cr比值。结果：高血压组和健康志愿者组双侧豆纹动脉数量分别为5.12±0.98、6.10±0.95,差异有统计学意义（P〈0.000 1）。高血压组患者NAA/Cr比值的降低与豆纹动脉数量减少具有一定相关性,单侧豆纹动脉数量≤3时,NAA/Cr比值下降得更显著。结论：高血压患者豆纹动脉数量减少至一定范围可引起基底节区脑代谢物NAA/Cr比值的降低。
Bibliography:31-1794/R
Objective：To evaluate the correlation between changes in brain metabolism and the reduction in small arteries in patients with hypertension.Methods：Fifty patients with hypertension and fifty volunteers without hypertension were enrolled.The two groups underwent 3T 3Dtime of flight MR angiography（MRA）and Single voxel proton MR spectroscopic（MRS）.The numbers of lenticulostriate arteries（LSAs）and the ratios of Nacetylaspartate to creatine（NAA/Cr）,myoinositol to creatine（MI/Cr）,and choline to creatine（Cho/Cr）on the basal ganglia regions were calculated.Results：The average total number of LSA stems on both sides in patients with hypertension and volunteers without hypertension was 5.12±0.98 and 6.10±0.95,respectively（P〈0.000 1）.The NAA/Cr ratio decreased according to a reduction in the number of LSAs in the hypertension group,which was significantly reduced when the number of LSAs was 3or fewer.Conclusions： Hypertension can lead to a statistically significant reduction in NAA/Cr ratio on the basal ganglia
ISSN:1008-6358
DOI:10.12025/j.issn.1008-6358.2017.20161132