c—MET在非小细胞肺癌中的作用机制及其治疗和检测

肝细胞生长因子／c-MET（hepatocyte growth factor／c—MET,HGF／c-MET）信号通路可通过多种机制如c-MET突变、扩增、过表达和HGF过表达被异常激活，并在非小细胞肺癌（non—small cell lung cancer,NSCLC）的发生发展以及表皮生长因子受体抑制剂（epidermal growth factor receptor tyrosine kinase inhibitor,EGFR-TKI）的耐药性方面发挥重要作用。因此，c-MET是继EGFR、ALK之后NSCLC的又一分子治疗靶点。目前c-MET抑制剂在一些临床试验中表现出了良好的的应用前...

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Bibliographic Details
Published in中国肺癌杂志 Vol. 18; no. 12; pp. 745 - 751
Main Author 梁红格 王孟昭
Format Journal Article
LanguageChinese
Published 中国医学科学院中国协和医科大学北京协和医学院呼吸内科,北京,100730 2015
Subjects
c-MET
HGF
检测
治疗
肺肿瘤
治疗
Treatment
HGF
检测
c-MET
肺肿瘤
Lung neoplasms
Testing
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ISSN1009-3419
1999-6187
DOI10.3779/j.issn.1009-3419.2015.12.06

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Summary:肝细胞生长因子／c-MET（hepatocyte growth factor／c—MET,HGF／c-MET）信号通路可通过多种机制如c-MET突变、扩增、过表达和HGF过表达被异常激活，并在非小细胞肺癌（non—small cell lung cancer,NSCLC）的发生发展以及表皮生长因子受体抑制剂（epidermal growth factor receptor tyrosine kinase inhibitor,EGFR-TKI）的耐药性方面发挥重要作用。因此，c-MET是继EGFR、ALK之后NSCLC的又一分子治疗靶点。目前c-MET抑制剂在一些临床试验中表现出了良好的的应用前景，但其在临床应用中的有效性和安全性的评估，以及对于c—MET检测方法的选择及判定标准还需进一步讨论。本文就c-MET在NSCLC中的作用机制、治疗前景和检测方法的选择作一综述。
Bibliography:Hepatocyte growth factor/c-MET （HGF/c-MET） signaling pathway can be abnormal activated by many mechanisms such as c-MET mutation, amplification and the overexpression of HGF, and it plays an important role in the development of non-small cell lung cancer （NSCLC）, as well as in the tolerance of epidermal growth factor receptor tyrosine kinase inhibitor （EGFR-TKI） in NSCLC. Therefore, c-MET is a new molecular target for the therapy of NSCLC since EGFR and ALK. At present, although the c-MET inhibitors have shown a potential prospect in some clinical trials, its assessment of safety and effectiveness in clinical applications, and the choice of testing methods and standards still need a further discussion. In this paper, we summarized the mechanism of c-MET in NSCLC, as well as its treatment prospect and selection of testing methods.
Hongge LIANG, Mengzhao WANG （Chinese Academy of Medical Sciences, Chinese Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China）
12-1395/R
Lung neop
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2015.12.06