Genetic variations of the Hemagglutinin gene of Pandemic Influenza A (H1N1) viruses in Assam, India during 2016
Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm...
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| Published in | 3 Biotech Vol. 8; no. 10; pp. 408 - 5 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Cham
Springer International Publishing
01.10.2018
Springer Nature B.V |
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| Online Access | Get full text |
| ISSN | 2190-572X 2190-5738 |
| DOI | 10.1007/s13205-018-1427-4 |
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| Abstract | Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm09 strains from Assam circulating in 2016 that caused a mild outbreak without any reported mortality. Sequence analysis of the HA gene of 20 positive Assam/H1N1pdm09 strains revealed 3 mutations (K180Q, S202T, S220T) at the antigenic sites along with several other reported mutations which are in close proximity to the antigenic sites and therefore might affect the viral antigenicity. Phylogenetically, the Assam/H1N1pdm09 strains clustered into genogroup 6B. These genetic variations highlight the importance of continuous surveillance and characterization of Influenza A/H1N1pdm09 virus activity to track the genetic makeup and diversification that may affect the behavior of the virus. |
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| AbstractList | Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm09 strains from Assam circulating in 2016 that caused a mild outbreak without any reported mortality. Sequence analysis of the HA gene of 20 positive Assam/H1N1pdm09 strains revealed 3 mutations (K180Q, S202T, S220T) at the antigenic sites along with several other reported mutations which are in close proximity to the antigenic sites and therefore might affect the viral antigenicity. Phylogenetically, the Assam/H1N1pdm09 strains clustered into genogroup 6B. These genetic variations highlight the importance of continuous surveillance and characterization of Influenza A/H1N1pdm09 virus activity to track the genetic makeup and diversification that may affect the behavior of the virus. Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm09 strains from Assam circulating in 2016 that caused a mild outbreak without any reported mortality. Sequence analysis of the HA gene of 20 positive Assam/H1N1pdm09 strains revealed 3 mutations (K180Q, S202T, S220T) at the antigenic sites along with several other reported mutations which are in close proximity to the antigenic sites and therefore might affect the viral antigenicity. Phylogenetically, the Assam/H1N1pdm09 strains clustered into genogroup 6B. These genetic variations highlight the importance of continuous surveillance and characterization of Influenza A/H1N1pdm09 virus activity to track the genetic makeup and diversification that may affect the behavior of the virus.Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm09 strains from Assam circulating in 2016 that caused a mild outbreak without any reported mortality. Sequence analysis of the HA gene of 20 positive Assam/H1N1pdm09 strains revealed 3 mutations (K180Q, S202T, S220T) at the antigenic sites along with several other reported mutations which are in close proximity to the antigenic sites and therefore might affect the viral antigenicity. Phylogenetically, the Assam/H1N1pdm09 strains clustered into genogroup 6B. These genetic variations highlight the importance of continuous surveillance and characterization of Influenza A/H1N1pdm09 virus activity to track the genetic makeup and diversification that may affect the behavior of the virus. |
| ArticleNumber | 408 |
| Author | Biswas, Dipankar Das, Palash Kumar Jakharia, Aniruddha Sarmah, Kimmi Sarma, Kishore Borkakoty, Biswajyoti Das, Mandakini Hazarika, Rahul |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30237955$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.2807/1560-7917.ES2014.19.9.20727 10.1016/j.jcv.2009.06.004 10.1371/journal.pone.0016087 10.1016/j.meegid.2017.01.027 10.1128/JVI.00697-12 10.2807/1560-7917.ES.2016.21.5.30124 10.1371/journal.pone.0029129 10.1128/mr.56.1.152-179.1992 10.1016/j.chom.2015.02.019 10.1136/bmj.h4966 10.1016/j.ijid.2013.01.028 10.1093/infdis/jix635 10.1371/journal.pone.0010540 10.1371/journal.pone.0168464 10.1371/currents.RRN1162 |
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| SubjectTerms | Agriculture Antigenicity Antigens Bioinformatics Biological evolution Biomaterials Biotechnology Cancer Research Chemistry Chemistry and Materials Science Emergence genes Genetic diversity genetic variation Hemagglutinins India Influenza Influenza A Influenza A virus monitoring mortality Mutation Outbreaks pandemic Pandemics Phylogeny Sequence analysis Short Reports Stem Cells Strains (organisms) Viruses |
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| Title | Genetic variations of the Hemagglutinin gene of Pandemic Influenza A (H1N1) viruses in Assam, India during 2016 |
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