Genetic variations of the Hemagglutinin gene of Pandemic Influenza A (H1N1) viruses in Assam, India during 2016

Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm...

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Published in3 Biotech Vol. 8; no. 10; pp. 408 - 5
Main Authors Sarmah, Kimmi, Borkakoty, Biswajyoti, Sarma, Kishore, Hazarika, Rahul, Das, Palash Kumar, Jakharia, Aniruddha, Das, Mandakini, Biswas, Dipankar
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.10.2018
Springer Nature B.V
Subjects
Agriculture
Antigenicity
Antigens
Bioinformatics
Biological evolution
Biomaterials
Biotechnology
Cancer Research
Chemistry
Chemistry and Materials Science
Emergence
genes
Genetic diversity
genetic variation
Hemagglutinins
India
Influenza
Influenza A
Influenza A virus
monitoring
mortality
Mutation
Outbreaks
pandemic
Pandemics
Phylogeny
Sequence analysis
Short Reports
Stem Cells
Strains (organisms)
Viruses
Assam India
India
Influenza A virus
Assam
Swine flu H1N1
Hemagglutinin
Genetic variation
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ISSN2190-572X
2190-5738
DOI10.1007/s13205-018-1427-4

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Summary:Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm09 strains from Assam circulating in 2016 that caused a mild outbreak without any reported mortality. Sequence analysis of the HA gene of 20 positive Assam/H1N1pdm09 strains revealed 3 mutations (K180Q, S202T, S220T) at the antigenic sites along with several other reported mutations which are in close proximity to the antigenic sites and therefore might affect the viral antigenicity. Phylogenetically, the Assam/H1N1pdm09 strains clustered into genogroup 6B. These genetic variations highlight the importance of continuous surveillance and characterization of Influenza A/H1N1pdm09 virus activity to track the genetic makeup and diversification that may affect the behavior of the virus.
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ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-018-1427-4