超敏C反应蛋白在反流性胆管炎胆汁病原菌构成中的作用

目的：了解反流性胆管炎患者胆汁病原菌的分布及其对抗菌药物敏感性，探讨血清超敏C反应蛋白（hs-CRP）在胆汁病原菌构成中的作用。方法选取2012年3月至2015年9月该院诊治的反流性胆管炎患者68例作为研究对象，收集胆汁标本进行细菌培养、血培养和药敏分析，并检测患者hs-CRP和白细胞计数的变化。结果胆汁细菌培养阳性率、血培养阳性率、hs-CRP和白细胞计数阳性率分别为100.00%、39.71%、82.35%和63.24%，不同指标检测阳性率比较，差异有统计学意义（P〈0.05）；治疗后hs-CRP水平较治疗前显著降低，差异有统计学意义（P〈0.05）；共培养出细菌81株，其中革兰阴性菌（G...

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Bibliographic Details
Published in现代医药卫生 Vol. 32; no. 15; pp. 2322 - 2324
Main Author 杨晓蓉 李芙梅
Format Journal Article
LanguageChinese
Published 石柱县万朝乡卫生院检验科,重庆,409100 2016
Subjects
C反应蛋白质
微生物敏感性试验
抗菌药
白细胞
胃食管反流
胆管炎
Gastroesophageal reflux
胆管炎
C-reactive protein
Microbial sensitivity tests
Anti-bacterial agents
Cholangitis
抗菌药
白细胞
微生物敏感性试验
Leukocytes
胃食管反流
C反应蛋白质
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ISSN1009-5519
DOI10.3969/j.issn.1009-5519.2016.15.017

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Summary:目的：了解反流性胆管炎患者胆汁病原菌的分布及其对抗菌药物敏感性，探讨血清超敏C反应蛋白（hs-CRP）在胆汁病原菌构成中的作用。方法选取2012年3月至2015年9月该院诊治的反流性胆管炎患者68例作为研究对象，收集胆汁标本进行细菌培养、血培养和药敏分析，并检测患者hs-CRP和白细胞计数的变化。结果胆汁细菌培养阳性率、血培养阳性率、hs-CRP和白细胞计数阳性率分别为100.00%、39.71%、82.35%和63.24%，不同指标检测阳性率比较，差异有统计学意义（P〈0.05）；治疗后hs-CRP水平较治疗前显著降低，差异有统计学意义（P〈0.05）；共培养出细菌81株，其中革兰阴性菌（G-菌）62株（76.54%）、革兰阳性菌（G＋菌）19株（23.46%），排名前3位的病原菌分别为大肠埃希菌（38.27%）、肺炎克雷伯菌（19.75%）和粪肠球菌（12.35%）；G-菌对亚胺培南的敏感性最高，其次分别为头孢哌酮、头孢噻肟、阿米卡星；G＋菌对万古霉素的敏感性最高，其次为环丙沙星、庆大霉素、复方新诺明和氨苄西林。结论 hs-CRP是诊断反流性胆管炎的有效指标之一，胆汁病原菌种类繁多，临床应依据药敏试验结果选择合适的抗菌药物。
Bibliography:Cholangitis; Gastroesophageal reflux; Leukocytes; C-reactive protein; Anti-bacterial agents; Microbial sensitivity tests
Objective To understand the distribution and antimicrobial susceptibility of pathogenic bacteria in the pa-tients with bile reflux cholangitis,and to focus on the role of serum high sensitive C reactive protein（hs-CRP） in the composition of bile pathogenic bacteria. Methods Sixty-eight cases of reflux cholangitis in our hospital from March 2012 to September 2015 were selected as the research subjects. The bile specimens were collected for conducting bacterial culture ,blood culture and drug sensitivity analysis,and the changes of hs-CRP and white blood cell（WBC） count were also detected. Results The positive rate of bile bacteria,positive rate of blood culture and positive rate of hs-CRP and WBC count were 100.00%,39.71%,82.35%and 63.24%respectively,the differences between the groups were statistically significant（P〈0.05）;moreover,the hs-CRP level after treatment was significantly decreased
ISSN:1009-5519
DOI:10.3969/j.issn.1009-5519.2016.15.017