Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease

• Published in: Clinical and molecular hepatology Vol. 21; no. 3; pp. 279 - 286
• Main Authors: An, Chansik, Choi, Youn Ah, Choi, Dongil, Paik, Yong Han, Ahn, Sang Hoon, Kim, Myeong-Jin, Paik, Seung Woon, Han, Kwang-Hyub, Park, Mi-Suk
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Association for the Study of the Liver 01.09.2015; The Korean Association for the Study of the Liver; 대한간학회
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol; Antiviral Agents - therapeutic use; At risk populations; Biopsy; Carcinoma, Hepatocellular - complications; Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - pathology; Demography; Female; Follow-up studies; Hepatitis B; Hepatitis B, Chronic - complications; Hepatitis B, Chronic - drug therapy; Hepatitis C; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - drug therapy; Hepatocellular carcinoma; Hospitals; Humans; Infections; Linear Models; Liver cancer; Liver diseases; Liver neoplasm; Liver Neoplasms - complications; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - pathology; Liver transplants; Magnetic Resonance Imaging; Male; Medical prognosis; Medical records; Middle Aged; Neoplasm Staging; Original; Patients; Regression analysis; Republic of Korea; Retrospective Studies; Statistical analysis; Surveillance; Tertiary Care Centers; Tomography, X-Ray Computed; Tumor burden; 내과학; United States > US; Liver neoplasm; Tumor burden; Hepatocellular carcinoma; Surveillance; Follow-up studies
• ISSN: 2287-2728; 2287-285X
• DOI: 10.3350/cmh.2015.21.3.279

The goal of this study was to estimate the growth rate of hepatocellular carcinoma (HCC) and identify the host factors that significantly affect this rate. Patients with early-stage HCC (n=175) who underwent two or more serial dynamic imaging studies without any anticancer treatment at two tertiary care hospitals in Korea were identified. For each patient, the tumor volume doubling time (TVDT) of HCC was calculated by comparing tumor volumes between serial imaging studies. Clinical and laboratory data were obtained from the medical records of the patients. The median TVDT was 85.7 days, with a range of 11 to 851.2 days. Multiple linear regression revealed that the initial tumor diameter (a tumor factor) and the etiology of chronic liver disease (a host factor) were significantly associated with the TVDT. The TVDT was shorter when the initial tumor diameter was smaller, and was shorter in HCC related to hepatitis B virus (HBV) infection than in HCC related to hepatitis C virus (HCV) infection (median, 76.8 days vs. 137.2 days; P=0.0234). The etiology of chronic liver disease is a host factor that may significantly affect the growth rate of early-stage HCC, since HBV-associated HCC grows faster than HCV-associated HCC.