胸腔积液沉淀物在恶性胸腔积液诊断中的临床应用价值
背景与目的恶性胸腔积液（malignant pleural effusion,MPE）是原发于胸膜或转移至胸膜的恶性肿瘤造成的胸腔积液。MPE患者预后差,应在减少病人痛苦的前提下,准确而快速的明确MPE的性质及病因,为后续治疗提供有效依据。方法 103例患者应用自然静止法或血凝集法制得胸水沉淀物,结合HE染色及免疫组化染色,在诊断MPE上与其他方法相比较。结果 103例MPE中,胸腔积液沉淀物方法确诊90例（诊断率87.4%）;32例仅通过沉淀物诊断,74例指出病理类型,23例明确原发灶;与71例同时行有创方法比较,诊断率为81.7%与87.3%;对比液基细胞学,检出率为86.7%和44.0%...
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| Published in | 中国肺癌杂志 Vol. 20; no. 6; pp. 395 - 401 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
天津医科大学总医院肿瘤科, 天津,300052
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-3419 1999-6187 |
| DOI | 10.3779/j.issn.1009-3419.2017.06.05 |
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| Abstract | 背景与目的恶性胸腔积液（malignant pleural effusion,MPE）是原发于胸膜或转移至胸膜的恶性肿瘤造成的胸腔积液。MPE患者预后差,应在减少病人痛苦的前提下,准确而快速的明确MPE的性质及病因,为后续治疗提供有效依据。方法 103例患者应用自然静止法或血凝集法制得胸水沉淀物,结合HE染色及免疫组化染色,在诊断MPE上与其他方法相比较。结果 103例MPE中,胸腔积液沉淀物方法确诊90例（诊断率87.4%）;32例仅通过沉淀物诊断,74例指出病理类型,23例明确原发灶;与71例同时行有创方法比较,诊断率为81.7%与87.3%;对比液基细胞学,检出率为86.7%和44.0%。结论胸腔积液沉淀物方法不仅可以增加细胞学诊断率且与其他有创方法诊断率近乎一致,同样可确定MPE病理类型及原发灶,是有创方法的较佳补充,甚至对于部分患者胸水沉淀物是唯一确诊方法。 |
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| AbstractList | 背景与目的恶性胸腔积液（malignant pleural effusion,MPE）是原发于胸膜或转移至胸膜的恶性肿瘤造成的胸腔积液。MPE患者预后差,应在减少病人痛苦的前提下,准确而快速的明确MPE的性质及病因,为后续治疗提供有效依据。方法 103例患者应用自然静止法或血凝集法制得胸水沉淀物,结合HE染色及免疫组化染色,在诊断MPE上与其他方法相比较。结果 103例MPE中,胸腔积液沉淀物方法确诊90例（诊断率87.4%）;32例仅通过沉淀物诊断,74例指出病理类型,23例明确原发灶;与71例同时行有创方法比较,诊断率为81.7%与87.3%;对比液基细胞学,检出率为86.7%和44.0%。结论胸腔积液沉淀物方法不仅可以增加细胞学诊断率且与其他有创方法诊断率近乎一致,同样可确定MPE病理类型及原发灶,是有创方法的较佳补充,甚至对于部分患者胸水沉淀物是唯一确诊方法。 背景与目的 恶性胸腔积液(malignant pleural effusion,MPE)是原发于胸膜或转移至胸膜的恶性肿瘤造成的胸腔积液.MPE患者预后差,应在减少病人痛苦的前提下,准确而快速的明确MPE的性质及病因,为后续治疗提供有效依据.方法 103例患者应用自然静止法或血凝集法制得胸水沉淀物,结合HE染色及免疫组化染色,在诊断MPE上与其他方法相比较.结果 103例MPE中,胸腔积液沉淀物方法确诊90例(诊断率87.4%);32例仅通过沉淀物诊断,74例指出病理类型,23例明确原发灶;与71例同时行有创方法比较,诊断率为81.7%与87.3%;对比液基细胞学,检出率为86.7%和44.0%.结论 胸腔积液沉淀物方法不仅可以增加细胞学诊断率且与其他有创方法诊断率近乎一致,同样可确定MPE病理类型及原发灶,是有创方法的较佳补充,甚至对于部分患者胸水沉淀物是唯一确诊方法. |
| Abstract_FL | Background and objective Malignant pleural effusion (MPE) is due tumor which arises from the me-sothelium or metastases from tumor origniating other sites. Generally, the prognosis of MPE is poor, in the premise of reduc-ing the pain of patients, as soon as possible make clear the property of pleural effusion and cause of the disesease, rightly and quickly, providing effective information for subsequent treatment. Methods The cell block of 103 patients by using natural sedimentation or plasma coagulation method combined with HE staining and immunohistochemical staining method maked clear diagnosis and compared with other methods. Results 90 patients were diagnosed by cell block section from 103 patients who had MPE (diagnostic rate 87.4%); 32 cases were diagnosed by cell block section only, 74 cases pointed out that the patho-logical type , 23 cases even pointed out the primary lesions; 71 cases examined other invasive methods at the same time, the di-agnostic rate was 87.3% and 81.7%; the detection rate of cell block section and cytological smear in detecting malignant tumor cells was 86.7%and 44.0% respectively. Conclusion Cell block can not only increase the diagnosis, in contrast to cytological smear, and own the same diagnostic rate compared with other invasive methods, but also can confirm pathological type and primary lesion; especially, for other invasive methods, cell block method is a preferable complementary method, and that cell block method maybe the only way for some patients. |
| Author | 王欣同 程方圆 钟殿胜 张丽沙 孟凡路 邵宜 于涛 |
| AuthorAffiliation | 天津医科大学总医院肿瘤科,天津300052 |
| AuthorAffiliation_xml | – name: 天津医科大学总医院肿瘤科, 天津,300052 |
| Author_FL | Diansheng ZHONG Lisha ZHANG Yi SHAO Fanlu MENG Tao YU Fangyuan CHENG Xintong WANG |
| Author_FL_xml | – sequence: 1 fullname: Xintong WANG – sequence: 2 fullname: Fangyuan CHENG – sequence: 3 fullname: Diansheng ZHONG – sequence: 4 fullname: Lisha ZHANG – sequence: 5 fullname: Fanlu MENG – sequence: 6 fullname: Yi SHAO – sequence: 7 fullname: Tao YU |
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| Keywords | Clinical value 恶性胸腔积液 临床价值 免疫组化染色 自然静止法 Natural sedimentation Plasma coagulation method Malignant pleural effusion 血液凝集法 Imunohistochemical staining |
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| Notes | Background and objective Malignant pleural effusion（MPE） is due tumor which arises from the mesothelium or metastases from tumor origniating other sites. Generally, the prognosis of MPE is poor, in the premise of reducing the pain of patients, as soon as possible make clear the property of pleural effusion and cause of the disesease, rightly and quickly, providing effective information for subsequent treatment. Methods The cell block of 103 patients by using natural sedimentation or plasma coagulation method combined with HE staining and immunohistochemical staining method maked clear diagnosis and compared with other methods. Results 90 patients were diagnosed by cell block section from 103 patients who had MPE（diagnostic rate 87.4%）; 32 cases were diagnosed by cell block section only, 74 cases pointed out that the pathological type, 23 cases even pointed out the primary lesions; 71 cases examined other invasive methods at the same time, the diagnostic rate was 87.3% and 81.7%; the detection rate of cell blo |
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| Publisher | 天津医科大学总医院肿瘤科, 天津,300052 |
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| Snippet | 背景与目的恶性胸腔积液（malignant pleural effusion,MPE）是原发于胸膜或转移至胸膜的恶性肿瘤造成的胸腔积液。MPE患者预后差,应在减少病人痛苦的前提下,准确而快速的明... 背景与目的 恶性胸腔积液(malignant pleural effusion,MPE)是原发于胸膜或转移至胸膜的恶性肿瘤造成的胸腔积液.MPE患者预后差,应在减少病人痛苦的前提下,准确而快速的明... |
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| SubjectTerms | 临床价值 免疫组化染色 恶性胸腔积液 自然静止法 血液凝集法 |
| Title | 胸腔积液沉淀物在恶性胸腔积液诊断中的临床应用价值 |
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