胸腔积液沉淀物在恶性胸腔积液诊断中的临床应用价值

背景与目的恶性胸腔积液（malignant pleural effusion,MPE）是原发于胸膜或转移至胸膜的恶性肿瘤造成的胸腔积液。MPE患者预后差,应在减少病人痛苦的前提下,准确而快速的明确MPE的性质及病因,为后续治疗提供有效依据。方法 103例患者应用自然静止法或血凝集法制得胸水沉淀物,结合HE染色及免疫组化染色,在诊断MPE上与其他方法相比较。结果 103例MPE中,胸腔积液沉淀物方法确诊90例（诊断率87.4%）;32例仅通过沉淀物诊断,74例指出病理类型,23例明确原发灶;与71例同时行有创方法比较,诊断率为81.7%与87.3%;对比液基细胞学,检出率为86.7%和44.0%...

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Bibliographic Details
Published in中国肺癌杂志 Vol. 20; no. 6; pp. 395 - 401
Main Author 王欣同 程方圆 钟殿胜 张丽沙 孟凡路 邵宜 于涛
Format Journal Article
LanguageChinese
Published 天津医科大学总医院肿瘤科, 天津,300052 2017
Subjects
临床价值
免疫组化染色
恶性胸腔积液
自然静止法
血液凝集法
Clinical value
恶性胸腔积液
临床价值
免疫组化染色
自然静止法
Natural sedimentation
Plasma coagulation method
Malignant pleural effusion
血液凝集法
Imunohistochemical staining
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ISSN1009-3419
1999-6187
DOI10.3779/j.issn.1009-3419.2017.06.05

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Summary:背景与目的恶性胸腔积液（malignant pleural effusion,MPE）是原发于胸膜或转移至胸膜的恶性肿瘤造成的胸腔积液。MPE患者预后差,应在减少病人痛苦的前提下,准确而快速的明确MPE的性质及病因,为后续治疗提供有效依据。方法 103例患者应用自然静止法或血凝集法制得胸水沉淀物,结合HE染色及免疫组化染色,在诊断MPE上与其他方法相比较。结果 103例MPE中,胸腔积液沉淀物方法确诊90例（诊断率87.4%）;32例仅通过沉淀物诊断,74例指出病理类型,23例明确原发灶;与71例同时行有创方法比较,诊断率为81.7%与87.3%;对比液基细胞学,检出率为86.7%和44.0%。结论胸腔积液沉淀物方法不仅可以增加细胞学诊断率且与其他有创方法诊断率近乎一致,同样可确定MPE病理类型及原发灶,是有创方法的较佳补充,甚至对于部分患者胸水沉淀物是唯一确诊方法。
Bibliography:Background and objective Malignant pleural effusion（MPE） is due tumor which arises from the mesothelium or metastases from tumor origniating other sites. Generally, the prognosis of MPE is poor, in the premise of reducing the pain of patients, as soon as possible make clear the property of pleural effusion and cause of the disesease, rightly and quickly, providing effective information for subsequent treatment. Methods The cell block of 103 patients by using natural sedimentation or plasma coagulation method combined with HE staining and immunohistochemical staining method maked clear diagnosis and compared with other methods. Results 90 patients were diagnosed by cell block section from 103 patients who had MPE（diagnostic rate 87.4%）; 32 cases were diagnosed by cell block section only, 74 cases pointed out that the pathological type, 23 cases even pointed out the primary lesions; 71 cases examined other invasive methods at the same time, the diagnostic rate was 87.3% and 81.7%; the detection rate of cell blo
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2017.06.05