改善肝脏微循环障碍的必要性和相关中药的筛选

慢性肝病常伴有肝脏微循环障碍,使得血液流动减慢甚至流量减少,导致门静脉高压。改善肝脏微循环与干预细胞外基质代谢在抗肝纤维化中具有同等的地位。现代医学的微循环障碍与中医学的瘀血含义有相同之处,应用有抗肝纤维化作用的活血化瘀中药或成分能够改善肝脏微循环、降低门静脉高压。介绍了体内外实验研究中药及组分改善肝脏微循环的作用及机制。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 29; no. 4; pp. 257 - 259
Main Author 徐列明
Format Journal Article
LanguageChinese
Published 上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203 2013
Subjects
中草药
微循环
慢性肝病
活血化瘀剂
高血压,门静脉
慢性肝病
微循环
活血化瘀剂
中草药
高血压,门静脉
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ISSN1001-5256

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Summary:慢性肝病常伴有肝脏微循环障碍,使得血液流动减慢甚至流量减少,导致门静脉高压。改善肝脏微循环与干预细胞外基质代谢在抗肝纤维化中具有同等的地位。现代医学的微循环障碍与中医学的瘀血含义有相同之处,应用有抗肝纤维化作用的活血化瘀中药或成分能够改善肝脏微循环、降低门静脉高压。介绍了体内外实验研究中药及组分改善肝脏微循环的作用及机制。
Bibliography:chronic liver diseases ; microcirculation ; hypertension, portal; drugs, Chinese herbal; BLOOD ACT STASIS REMOV AGENTS
XU Lieming. （Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine ; Key Laboratory of Liver and Kidney Diseases, Ministry of Education ; Key Laboratory of Traditional Chinese Medicine, Shanghai 201203, China）
Chronic liver diseases are frequently accompanied by changes in the organ＇s microcirculatory system. Changes in the vascular ar- chitecture can affect the rate of blood flow, which in turn may promote the underlying pathogenic etiology ; for example, recent studies have indicated that decreased blood flow in the liver can suppress the clearance rate of pathogenic agents （such as hepatitis virus）, enhance local- ized inflammation and or fibrosis -related injmT, or increase pressure in the portal vein. The phenomenon of obstructed liver microcircula- tion in modern medicine is sim
ISSN:1001-5256