STUDIES ON THE ANTITUMOR ACTIVITY AND ISOLATION OF THE GLYCOPROTEIN FROM THE GONAD OF CHLAMYS (AZUMAPECTEN) FARRERI

After being degreased with acetone, the female gonad of Chlamys (Azumapecten) farreri was extracted with water, and then subjected to DEAE - cellulose column chromatography and purified by Sephadex G - 100 chromatography to obtain a pure female gonad glycoprotein (FGGP). The IR spectra, electrophore...

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Published inChinese journal of oceanology and limnology Vol. 16; no. 4; pp. 359 - 363
Main Author 顾谦群 方玉春 王长云 肖航 秦玉青
Format Journal Article
LanguageEnglish
Published 1998
Subjects
activity
antitumor
Azumapecten
Chlamys
Chlamys farreri
farreri
glycoprotein
gonad
Marine
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ISSN0254-4059
1993-5005

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Summary:After being degreased with acetone, the female gonad of Chlamys (Azumapecten) farreri was extracted with water, and then subjected to DEAE - cellulose column chromatography and purified by Sephadex G - 100 chromatography to obtain a pure female gonad glycoprotein (FGGP). The IR spectra, electrophoresis and chemical analysis of FGGP indicated that it was a kind of acid glycoprotein and that the content of total protein and sugar were 54.8% and 40%, respectively. Pharmacological tests showed that FGGP could inhibit (inhibition rate of 40.87%) the growth of Sarcoma 180 of mice.
Bibliography:37-1150/P
GU Qian-qun; FANG Yu-chun; WANG Chang-yun;XIAO Hans; QIN Th-qing(Institute of Marine Drugs and Foods, Ocean University of Qingdaoo, Qingdao, 266003)
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ISSN:0254-4059
1993-5005