Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease

A sputum eosinophilia is observed in 10–40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophil...

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Bibliographic Details
Published in	Respirology (Carlton, Vic.) Vol. 20; no. 4; pp. 667 - 670
Main Authors	Eltboli, Osama, Mistry, Vijay, Barker, Bethan, Brightling, Chris E.
Format	Journal Article
Language	English
Published	Australia Blackwell Publishing Ltd 01.05.2015 John Wiley and Sons Inc
Subjects	Adult Basement Membrane - pathology Biomarkers - blood blood eosinophil chronic obstructive pulmonary disease Eosinophilia Eosinophils - pathology Female Humans Leukocyte Count Male Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - diagnosis remodelling reticular basement membrane Scientific Letter Scientific Letters submucosal eosinophil reticular basement membrane submucosal eosinophil remodelling blood eosinophil chronic obstructive pulmonary disease
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ISSN	1323-7799 1440-1843 1440-1843
DOI	10.1111/resp.12475

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Summary:	A sputum eosinophilia is observed in 10–40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophils and reticular basement membrane thickening and found these were positively correlated with the blood eosinophil percentage. In COPD, blood eosinophils are a good biomarker of bronchial eosinophilia and remodelling.
Bibliography:	Wellcome Trust Senior Fellowship ArticleID:RESP12475 Medical Research Council istex:029B0B9C85D64730958B9CF6D774B628A480EE61 ark:/67375/WNG-6T70L347-5 National Institute for Health Research (NIHR) Supplementary Table S1 Clinical characteristics of the COPD and control subjects stratified by the median peripheral blood eosinophil count percentage. Benghazi University Conflict of Interest Statement CEB has received grants and consultancy fees from GSK, Novartis, Genentech/Roche, Medimmune/AstraZeneca, Boerhinger‐Ingelheim and Chiesi. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 23 (Associate Editor: Shu Hashimoto).
ISSN:	1323-7799 1440-1843 1440-1843
DOI:	10.1111/resp.12475