乙肝相关肝癌患者肝组织硬脂酰-辅酶A脱氢酶的表达与预后的相关性
目的：探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶（stearoyl-CoA desaturase,SCD）的表达水平及临床意义。方法：构建176例距离肝癌边界3cm以上肝组织的组织芯片,应用免疫组化技术检测SCD的表达水平,并分析其与临床病理学特征之间的关系。结果：SCD在乙肝相关肝癌患者肝组织中的阳性率为85.80%（151/176）。且肝组织中SCD表达量与肿瘤数目、微血管侵犯、肝硬化等相关（P〈0.05）,SCD高水平表达组患者无瘤生存时间和总体生存时间均短于SCD低水平表达组。结论：SCD在乙肝相关肝癌患者肝组织中的表达量与临床病理及不良预后之间存在一定联系,提示肝癌患者肝组织中SCD...
Saved in:
| Published in | 中国临床医学 Vol. 23; no. 5; pp. 559 - 562 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
第二军医大学卫生勤务学系军队健康管理学教研室，上海 200433
2016
第二军医大学基础医学部，上海 200433%第二军医大学东方肝胆外科医院胆道三科,上海,200433%第二军医大学卫生勤务学系军队健康管理学教研室,上海,200433 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-6358 |
| DOI | 10.12025/j.issn.1008-6358.2016.20160026 |
Cover
| Abstract | 目的：探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶（stearoyl-CoA desaturase,SCD）的表达水平及临床意义。方法：构建176例距离肝癌边界3cm以上肝组织的组织芯片,应用免疫组化技术检测SCD的表达水平,并分析其与临床病理学特征之间的关系。结果：SCD在乙肝相关肝癌患者肝组织中的阳性率为85.80%（151/176）。且肝组织中SCD表达量与肿瘤数目、微血管侵犯、肝硬化等相关（P〈0.05）,SCD高水平表达组患者无瘤生存时间和总体生存时间均短于SCD低水平表达组。结论：SCD在乙肝相关肝癌患者肝组织中的表达量与临床病理及不良预后之间存在一定联系,提示肝癌患者肝组织中SCD的表达量可以作为不良预后的标志物。 |
|---|---|
| AbstractList | R735.7; 目的：探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶（stearoyl-CoA desaturase，SCD）的表达水平及临床意义。方法：构建176例距离肝癌边界3 cm以上肝组织的组织芯片，应用免疫组化技术检测SCD的表达水平，并分析其与临床病理学特征之间的关系。结果：SCD在乙肝相关肝癌患者肝组织中的阳性率为85．80％（151／176）。且肝组织中SCD表达量与肿瘤数目、微血管侵犯、肝硬化等相关（P＜0．05），SCD高水平表达组患者无瘤生存时间和总体生存时间均短于SCD低水平表达组。结论：SCD在乙肝相关肝癌患者肝组织中的表达量与临床病理及不良预后之间存在一定联系，提示肝癌患者肝组织中SCD的表达量可以作为不良预后的标志物。 目的：探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶（stearoyl-CoA desaturase,SCD）的表达水平及临床意义。方法：构建176例距离肝癌边界3cm以上肝组织的组织芯片,应用免疫组化技术检测SCD的表达水平,并分析其与临床病理学特征之间的关系。结果：SCD在乙肝相关肝癌患者肝组织中的阳性率为85.80%（151/176）。且肝组织中SCD表达量与肿瘤数目、微血管侵犯、肝硬化等相关（P〈0.05）,SCD高水平表达组患者无瘤生存时间和总体生存时间均短于SCD低水平表达组。结论：SCD在乙肝相关肝癌患者肝组织中的表达量与临床病理及不良预后之间存在一定联系,提示肝癌患者肝组织中SCD的表达量可以作为不良预后的标志物。 |
| Abstract_FL | Objective:To investigate the expression level and clinical significance of stearoyl-CoA desaturase (SCD)in liver tissues of HBV-related hepatocellular carcinoma (HCC)patients.Methods:We constructed the tissue microarray of liver tissue 3 cm beyond the HCC boundary (n= 176),detected the expression level of SCD by immunohistochemistry,and analyzed the relationship between the expression level and clinical pathological features.Results:The positive rate of SCD in liver tissues of patients with HBV-related HCC patients was 85.80% (151/176).The SCD expression level was associated with tumor number,microvascular invasion,liver cirrhosis (P< 0.05).The tumor free survival time and overall survival time of SCD high level expression group were both shorter than those of SCD low level expression group.Conclusions:The SCD expression level in the liver tissues of HBV-related HCC patients is related to clinical pathology and prognosis,which suggests that the expression of SCD in the liver tissues of HCC patients can be used as a marker of poor prognosis. |
| Author | 林晓平 汪珍光 孙金海 |
| AuthorAffiliation | 第二军医大学卫生勤务学系军队健康管理学教研室,上海200433 第二军医大学基础医学部,上海200433 第二军医大学东方肝胆外科医院胆道三科,上海200433 |
| AuthorAffiliation_xml | – name: 第二军医大学卫生勤务学系军队健康管理学教研室，上海 200433; 第二军医大学基础医学部，上海 200433%第二军医大学东方肝胆外科医院胆道三科,上海,200433%第二军医大学卫生勤务学系军队健康管理学教研室,上海,200433 |
| Author_FL | LIN Xiao-ping WANG Zhen-guang SUN Jin-hai |
| Author_FL_xml | – sequence: 1 fullname: LIN Xiao-ping – sequence: 2 fullname: WANG Zhen-guang – sequence: 3 fullname: SUN Jin-hai |
| Author_xml | – sequence: 1 fullname: 林晓平 汪珍光 孙金海 |
| BookMark | eNo9kL1OAkEQx7fARERewobqzrnd29u7khC_EhIbGiuyHLd4BA_lYhQrQu5iY4gtGguw0MICY2IwJDwNcMtbuICxmfnPzG9mMrODUkEz8BDKGaAbGDDdr-t-GAa6AWBrFqG2jsGw1gYAWymU_q9so2wY-hUAAygQDGl0Nvvpy-5L8jyex18r0X9YdF9lJ17pSZRM7pPBh4y6y3ikyWm8jL_zMvpcjIZKJU-RHLzL6XQ27i2H0fyxpzKbSYvO2y7aErwRetk_n0Glw4NS4Vgrnh6dFPJFzaWOqQlme7aJbZcT0yUm8VxatR1ickGrVpVzxoHzCrOJI1TkCKFgy-Qe9tR9THVlUG4z9oYHgge1cr153QrUwvJdreG2b9dvoACmIvc2pHveDGpXvmIvW_4Fb7XLFgPGMLUY-QXUcIMA |
| ClassificationCodes | R735.7 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.12025/j.issn.1008-6358.2016.20160026 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | The relationship between the expression of stearoyl-CoA desaturase in liver tissue and the prognosis of HBV-related hepatocellular carcinoma patients |
| DocumentTitle_FL | The relationship between the expression of stearoyl-CoA desaturase in liver tissue and the prognosis of HBV-related hepatocellular carcinoma patients |
| EndPage | 562 |
| ExternalDocumentID | zglcyx201605004 670772567 |
| GroupedDBID | 2RA 92L ALMA_UNASSIGNED_HOLDINGS CDYEO CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| ID | FETCH-LOGICAL-c594-f78e8428ca34c343ec5d8934af5d6daa7a0aab7839fdaa9ff84264ae2e2017ca3 |
| ISSN | 1008-6358 |
| IngestDate | Thu May 29 04:08:21 EDT 2025 Wed Feb 14 10:07:30 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 5 |
| Keywords | SCD stearoyl-CoA desaturase tissue microarray 组织芯片 immunohistochemistry 免疫组化 hepatocellular carcinoma 肝癌 |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c594-f78e8428ca34c343ec5d8934af5d6daa7a0aab7839fdaa9ff84264ae2e2017ca3 |
| Notes | 31-1794/R hepatocellular carcinoma; stearoyl-CoA desaturase; tissue microarray; immunohistochemistry LIN Xiao-ping1,2 , WANG Zhen-guang3, SUN Jin-hai1（1. Department of Health Management, Faculty of Health Service, Second Military Medical University, Shanghai 200433, China;2. College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China;3. Third Department of Biliary Tract, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China） Objective：To investigate the expression level and clinical significance of stearoyl-CoA desaturase（SCD）in liver tissues of HBV-related hepatocellular carcinoma（HCC）patients.Methods：We constructed the tissue microarray of liver tissue 3cm beyond the HCC boundary（n=176）,detected the expression level of SCD by immunohistochemistry,and analyzed the relationship between the expression level and clinical pathological features.Results：The positive rate of SCD in liver tissues of patients with HBV-related HCC pat |
| PageCount | 4 |
| ParticipantIDs | wanfang_journals_zglcyx201605004 chongqing_primary_670772567 |
| PublicationCentury | 2000 |
| PublicationDate | 2016 |
| PublicationDateYYYYMMDD | 2016-01-01 |
| PublicationDate_xml | – year: 2016 text: 2016 |
| PublicationDecade | 2010 |
| PublicationTitle | 中国临床医学 |
| PublicationTitleAlternate | Chinese Journal Of Clinical Medicine |
| PublicationYear | 2016 |
| Publisher | 第二军医大学卫生勤务学系军队健康管理学教研室，上海 200433 第二军医大学基础医学部，上海 200433%第二军医大学东方肝胆外科医院胆道三科,上海,200433%第二军医大学卫生勤务学系军队健康管理学教研室,上海,200433 |
| Publisher_xml | – name: 第二军医大学基础医学部，上海 200433%第二军医大学东方肝胆外科医院胆道三科,上海,200433%第二军医大学卫生勤务学系军队健康管理学教研室,上海,200433 – name: 第二军医大学卫生勤务学系军队健康管理学教研室，上海 200433 |
| SSID | ssib001050320 ssib006562945 ssib036441625 ssib001103563 ssib002262996 ssib008144075 ssib051368386 |
| Score | 2.0447607 |
| Snippet | 目的：探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶（stearoyl-CoA desaturase,SCD）的表达水平及临床意义。方法：构建176例距离肝癌边界3cm以上肝组织的组织芯片,应用免疫组... R735.7; 目的：探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶（stearoyl-CoA desaturase，SCD）的表达水平及临床意义。方法：构建176例距离肝癌边界3 cm以上肝组织的组织芯... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 559 |
| SubjectTerms | SCD 免疫组化 组织芯片 肝癌 |
| Title | 乙肝相关肝癌患者肝组织硬脂酰-辅酶A脱氢酶的表达与预后的相关性 |
| URI | http://lib.cqvip.com/qk/90920A/201605/670772567.html https://d.wanfangdata.com.cn/periodical/zglcyx201605004 |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals issn: 1008-6358 databaseCode: DOA dateStart: 20160101 customDbUrl: isFulltext: true dateEnd: 99991231 titleUrlDefault: https://www.doaj.org/ omitProxy: true ssIdentifier: ssib006562945 providerName: Directory of Open Access Journals |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9RAFA-lgngRRcValR4cPG3NJvN5nOxmKYKeKtTTkmSTFpGtHy1oT6Xs4kWK1yoeWg968FARpFLoX9N2t_-F772k2dSKX7CEt2_e-82897KZN7MzE8e55de9TqSkW4OuKqnxRKW1KI3x_SYc8g8dZ7HGjcL37suZB_zunJgbG2eVVUvLS_F0svLLfSX_E1XgQVxxl-w_RLYEBQbQEF-4QoTh-lcxZiFngWHGsFAz7THTZKFiJmCBZqFgWrDAP1lkmG6wUCLH5kUuilVlgoBpfkwoJGyd2QbJcBQLDSG7NWQFIennLGkLqaCOlQQus6W4pPotYWuC1IU-fNAOUAxRGFRQRjDjEqfUOm2ZxOZbVU2wCyjbJASQbxacgDADgLKE0ED7gABJW85OIqQJmVFEgGd9UjJQW1UEzLMWG6RbTDeLBmkzEiFYDItBF5rcGwCkqpMs-e5P-kGQlxvkZU5tbBCoRAtONJaDuWWrqQiIgHzDmWkRJ0AxJCy6eSSs0Gc5ToEMBupjLTBJFB4K8qiHpK4oDrKCA7qCjAMZF-vFopAqbbGgQY3P42lLu-nkyvwskqILxAUxkIbqah_p-ZVngah0eKI4zz3PnUTes57qlj2XXrL1iGqYLmvAlZWSLjgVMMpIynWiK_OPk5cvSEDQqb9nPJx2q8yc5LMawvUrox7IaH0hq1mqhKRrlHXDEMYzlT_TNS5wGGXRPg4R5KibE3Vfap_eGVu2_Kxz-9iuO7-3Cs9sWVjszj-FTJQ2BnazqDtfyWFnLzjni8HnlM2fJBedsZWFS87D_e8bw7X3g3c7B_2vSGy8Plz7MFztI73bG-y-Gmx-HvbWjvrbteFe_6j_zQ57Xw63t4AavO0NNz8N9_b2d9aPtnoHb9aBkyMdrn687My2wtnGTK144UotEYbXMqVTzT2dRD5PfO6niejAcIZHmejIThSpyI2iWMGQKoNvJss0Dqei1EvBWAVaV5zx7mI3vepMiQgwPKN4XI85liG2ybQfR27aybIJZ7L0SvtJfq5OWyoXxvpCqglnqvBTu3jaPm__dCtc-7PIpHMO6Xy-9LozvvRsOb0BI4il-CbdPz8Ai-jZKQ |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E4%B9%99%E8%82%9D%E7%9B%B8%E5%85%B3%E8%82%9D%E7%99%8C%E6%82%A3%E8%80%85%E8%82%9D%E7%BB%84%E7%BB%87%E7%A1%AC%E8%84%82%E9%85%B0-%E8%BE%85%E9%85%B6A%E8%84%B1%E6%B0%A2%E9%85%B6%E7%9A%84%E8%A1%A8%E8%BE%BE%E4%B8%8E%E9%A2%84%E5%90%8E%E7%9A%84%E7%9B%B8%E5%85%B3%E6%80%A7&rft.jtitle=%E4%B8%AD%E5%9B%BD%E4%B8%B4%E5%BA%8A%E5%8C%BB%E5%AD%A6&rft.au=%E6%9E%97%E6%99%93%E5%B9%B3&rft.au=%E6%B1%AA%E7%8F%8D%E5%85%89&rft.au=%E5%AD%99%E9%87%91%E6%B5%B7&rft.date=2016&rft.pub=%E7%AC%AC%E4%BA%8C%E5%86%9B%E5%8C%BB%E5%A4%A7%E5%AD%A6%E5%8D%AB%E7%94%9F%E5%8B%A4%E5%8A%A1%E5%AD%A6%E7%B3%BB%E5%86%9B%E9%98%9F%E5%81%A5%E5%BA%B7%E7%AE%A1%E7%90%86%E5%AD%A6%E6%95%99%E7%A0%94%E5%AE%A4%EF%BC%8C%E4%B8%8A%E6%B5%B7+200433&rft.issn=1008-6358&rft.volume=23&rft.issue=5&rft.spage=559&rft.epage=562&rft_id=info:doi/10.12025%2Fj.issn.1008-6358.2016.20160026&rft.externalDocID=zglcyx201605004 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F90920A%2F90920A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzglcyx%2Fzglcyx.jpg |