乙肝相关肝癌患者肝组织硬脂酰-辅酶A脱氢酶的表达与预后的相关性

目的：探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶（stearoyl-CoA desaturase,SCD）的表达水平及临床意义。方法：构建176例距离肝癌边界3cm以上肝组织的组织芯片,应用免疫组化技术检测SCD的表达水平,并分析其与临床病理学特征之间的关系。结果：SCD在乙肝相关肝癌患者肝组织中的阳性率为85.80%（151/176）。且肝组织中SCD表达量与肿瘤数目、微血管侵犯、肝硬化等相关（P〈0.05）,SCD高水平表达组患者无瘤生存时间和总体生存时间均短于SCD低水平表达组。结论：SCD在乙肝相关肝癌患者肝组织中的表达量与临床病理及不良预后之间存在一定联系,提示肝癌患者肝组织中SCD...

Full description

Saved in:
Bibliographic Details
Published in中国临床医学 Vol. 23; no. 5; pp. 559 - 562
Main Author 林晓平 汪珍光 孙金海
Format Journal Article
LanguageChinese
Published 第二军医大学卫生勤务学系军队健康管理学教研室，上海 200433 2016
第二军医大学基础医学部，上海 200433%第二军医大学东方肝胆外科医院胆道三科,上海,200433%第二军医大学卫生勤务学系军队健康管理学教研室,上海,200433
Subjects
SCD
免疫组化
组织芯片
肝癌
SCD
stearoyl-CoA desaturase
tissue microarray
组织芯片
immunohistochemistry
免疫组化
hepatocellular carcinoma
肝癌
Online AccessGet full text
ISSN1008-6358
DOI10.12025/j.issn.1008-6358.2016.20160026

Cover

More Information
Summary:目的：探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶（stearoyl-CoA desaturase,SCD）的表达水平及临床意义。方法：构建176例距离肝癌边界3cm以上肝组织的组织芯片,应用免疫组化技术检测SCD的表达水平,并分析其与临床病理学特征之间的关系。结果：SCD在乙肝相关肝癌患者肝组织中的阳性率为85.80%（151/176）。且肝组织中SCD表达量与肿瘤数目、微血管侵犯、肝硬化等相关（P〈0.05）,SCD高水平表达组患者无瘤生存时间和总体生存时间均短于SCD低水平表达组。结论：SCD在乙肝相关肝癌患者肝组织中的表达量与临床病理及不良预后之间存在一定联系,提示肝癌患者肝组织中SCD的表达量可以作为不良预后的标志物。
Bibliography:31-1794/R
hepatocellular carcinoma; stearoyl-CoA desaturase; tissue microarray; immunohistochemistry
LIN Xiao-ping1,2 , WANG Zhen-guang3, SUN Jin-hai1（1. Department of Health Management, Faculty of Health Service, Second Military Medical University, Shanghai 200433, China;2. College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China;3. Third Department of Biliary Tract, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China）
Objective：To investigate the expression level and clinical significance of stearoyl-CoA desaturase（SCD）in liver tissues of HBV-related hepatocellular carcinoma（HCC）patients.Methods：We constructed the tissue microarray of liver tissue 3cm beyond the HCC boundary（n=176）,detected the expression level of SCD by immunohistochemistry,and analyzed the relationship between the expression level and clinical pathological features.Results：The positive rate of SCD in liver tissues of patients with HBV-related HCC pat
ISSN:1008-6358
DOI:10.12025/j.issn.1008-6358.2016.20160026