氟康唑类似物的研究进展
氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物。随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课题。通过对氟康唑结构的修饰,获得新型氟康唑类似物,为进一步的新药合成研究提供线索。...
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| Published in | 药学实践杂志 Vol. 34; no. 2; pp. 110 - 113 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
第二军医大学药学院有机化学教研室,上海,200433
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-0111 |
| DOI | 10.3969/j.issn.1006-0111.2016.02.004 |
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| Abstract | 氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物。随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课题。通过对氟康唑结构的修饰,获得新型氟康唑类似物,为进一步的新药合成研究提供线索。 |
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| AbstractList | 氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物。随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课题。通过对氟康唑结构的修饰,获得新型氟康唑类似物,为进一步的新药合成研究提供线索。 R916%R978.5; 氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物.随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课题.通过对氟康唑结构的修饰,获得新型氟康唑类似物,为进一步的新药合成研究提供线索. |
| Abstract_FL | Fluconazole,the third generation of triazole-antifungal drug,becomes the first choice in the treatment of fun-gal infection due to its broad antifungal spectrum,good water solubility and low toxicity.With an increasingly drug-resistant strain,developing new fluconazole derivatives is becoming an attractive topic.This review mainly indicates that people can get new fluconazole derivatives used by clinic through structural modification of fluconazole,which will give clues for advanced re-search. |
| Author | 许克寒 黄蕾 吴俊琪 戚麟 金永生 俞世冲 |
| AuthorAffiliation | 第二军医大学药学院有机化学教研室,上海200433 |
| AuthorAffiliation_xml | – name: 第二军医大学药学院有机化学教研室,上海,200433 |
| Author_FL | XU Kehan WU Junqi QI Lin JIN Yongsheng YU Shichong HUANG Lei |
| Author_FL_xml | – sequence: 1 fullname: XU Kehan – sequence: 2 fullname: HUANG Lei – sequence: 3 fullname: WU Junqi – sequence: 4 fullname: QI Lin – sequence: 5 fullname: JIN Yongsheng – sequence: 6 fullname: YU Shichong |
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| Keywords | synthesis 合成 fluconazole antifungal agents 结构修饰 氟康唑 抗真菌药 structural modification |
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| Notes | 31-1685/R fluconazole; antifungal agents; structural modification; synthesis XU Kehan;HUANG Lei;WU Junqi;QI Lin;JIN Yongsheng;YU Shichong;Department of Organic Chemistry,School of Pharmacy,Second Military Medical University; Shanghai 200433, China Fluconazole,the third generation of triazole-antifungal drug,becomes the first choice in the treatment of fungal infection due to its broad antifungal spectrum,good water solubility and low toxicity.With an increasingly drug-resistant strain,developing new fluconazole derivatives is becoming an attractive topic.This review mainly indicates that people can get new fluconazole derivatives used by clinic through structural modification of fluconazole,which will give clues for advanced research. |
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| Snippet | 氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物。随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课... R916%R978.5; 氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物.随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为... |
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| SubjectTerms | 合成 抗真菌药 氟康唑 结构修饰 |
| Title | 氟康唑类似物的研究进展 |
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